Linseed supplementation during uterine and early post-natal life markedly affects fatty acid profiles of brain, liver and muscle of lambs

Nudda, Anna; Bee, Giuseppe; Correddu, Fabio; Lunesu, Mondina Francesca; Cesarani, Alberto; Rassu, S.P.G.; Pulina, Giuseppe; Battacone, Gianni

doi:10.1080/1828051x.2022.2038039

Cited by 5 publications

(4 citation statements)

References 76 publications

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“…Although DPA was approximately 10 times lower than DHA in the brain, it was more responsive to the dietary supply of n-3 PUFA. The same pattern was also observed in the brains of lambs suckling from ewes fed with linseed [34] and in the hippocampus of bovines fed fish oil [15].…”

Section: Brain Fa Compositionsupporting

confidence: 73%

Enrichment of Brain n-3 Docosapentaenoic Acid (DPA) and Retinal n-3 Eicosapentaenoic Acid (EPA) in Lambs Fed Nannochloropsis oceanica Microalga

Vítor

Correia

Alves

et al. 2023

Animals

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Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have special physiological functions in both brain and retinal tissues that are related to the modulation of inflammatory processes and direct effects on neuronal membrane fluidity, impacting mental and visual health. Among them, the long-chain (LC) n-3 PUFAs, as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are of special importance. Scarce data are available about the fatty acid (FA) composition of the ruminant brain in response to dietary intervention. However, we decided to examine the brain and retina FA composition of lambs supplemented with an EPA-rich microalga feed for 21 days, as it is known that despite the extensive biohydrogenation of dietary PUFAs in the rumen, ruminants can selectively accumulate some n-3 LC-PUFAs in their brain and retinal tissues. Twenty-eight male lambs were fed a control diet, or the same diet further supplemented with Nannochloropsis sp. microalga. Their brains and retina were collected for FA characterization. Overall, the brain FA profile remained unchanged, with little alteration in omega-3 docosapentaenoic acid (DPA) enhancement in both the hippocampus and prefrontal cortex. Retinal tissues were particularly responsive to the dietary intervention, with a 4.5-fold enhancement of EPA in the freeze-dried-fed lambs compared with the control lambs. We conclude that retinal tissues are sensitive to short-term n-3 PUFA supplementation in lambs.

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Section: Brain Fa Compositionsupporting

confidence: 73%

Enrichment of Brain n-3 Docosapentaenoic Acid (DPA) and Retinal n-3 Eicosapentaenoic Acid (EPA) in Lambs Fed Nannochloropsis oceanica Microalga

Vítor

Correia

Alves

et al. 2023

Animals

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“…The red meat industry is experiencing modernization in its production system to meet current consumer demands associated with health, quality of life, and sustainability ( 14 ). The profile and quality of fatty acids in lamb can be improved by incorporating lipid sources into the diet of lot-fed lambs to boost the levels of omega-3 long-chain polyunsaturated fatty acids (n-3 LC PUFA) known to be beneficial for human health ( 14 , 15 ). Meat industry producers and processors aim at producing heavy carcasses of young animals with good musculature, supplying desired meat cut yields and an attainable fat layer to protect carcasses while in cold storage ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

Fortification of diets with omega-3 long-chain polyunsaturated fatty acids enhances feedlot performance, intramuscular fat content, fat melting point, and carcass characteristics of Tattykeel Australian White MARGRA lambs

et al. 2022

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Meat eating quality indices such as intramuscular fat content (IMF) and fat melting point (FMP) of the Longissimus thoracis et lumborum muscle and the feedlot performance, carcass traits, and commercial wholesale cuts of lot-fed Tattykeel Australian White (TAW) MARGRA lambs as a result of dietary fortification of the diet with omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA) were evaluated. A total of 75 TAW MARGRA lambs at 6 months of age with an average liveweight of 30 ± 1.2 kg were used. The lambs were randomly allocated to the following three dietary treatments of 25 lambs each in a 47-day feeding trial using a completely randomized experimental design: (1) control diet of hay plus pellets without omega-3 oil, (2) hay plus commercial whole grain pellets (MSM) without omega-3 oil, and (3) hay plus pellets fortified with omega-3 oil. It was hypothesized that dietary supplementation with omega-3 fortified pellets will improve feedlot performance, meat-eating quality indices of IMF, FMP, and carcass characteristics. Lot-fed lambs on the MSM whole grain had the highest feed intake of 1.69 kg/day, followed by the control at 1.57 kg/day and the lowest in the omega-3 diet at 1.01 kg/day (p = 0.0001). However, the omega-3 diet had the highest average daily gain of 230 g/head/day (p = 0.0001), indicating the greatest feed efficiency since it had the best growth response with minimal feed intake. Post-slaughter evaluation of the Longissimus thoracis et lumborum muscle revealed significant treatment variations in IMF (p = 0.0001), FMP (p = 0.0001), pH (p = 0.0380), and wholesale French rack primal cut (p = 0.0001). Strong correlations (p < 0.05) between liveweight, temperature, pH, FMP, and IMF were observed. Similarly, significant correlations between carcass characteristics of total saleable meat yield, lean trim, fat trims, bones, and leg shank were evident (p < 0.05). However, there were no treatment differences in the final liveweight, GR fat depth, hot standard carcass weight, or dressing percentage. The findings indicate that feedlot performance, meat-eating quality traits such as IMF and FMP, and commercial wholesale French rack cuts can be further improved during feedlot finishing of TAW MARGRA lambs through dietary supplementation with omega-3 oils, and hence the tested hypothesis of improved meat quality attributes is partially confirmed.

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“…Maternal nutrition during pregnancy directly influences foetal development through changes in foetal programming and epigenetic regulation, which can induce phenotypic changes that affect foetal growth and the development and function of organs and tissues (Mennitti et al, 2015). A diet with lipids appears to influence the quality and composition of foetal tissues, such as the muscle, brain and liver (Nudda et al, 2022), as well as the composition of membranes, and acts as a precursor of important metabolites for foetal metabolism and development. A preference for placental plasma membrane binding sites for LC‐PUFA and a negative effect of trans‐FA (TFA) on foetuses may inhibit LC‐PUFA transport to the placenta (Campbell et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

Effect of peri‐conception high‐fat diets on maternal ovarian function, foetal and placentome growth, and vascular umbilical development in goats

Cavalcanti

Silva

Conde

et al. 2022

Reprod Domestic Animals

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The objective of this study was to determine whether a high‐fat diet (HFD) fed to goats for a brief period during peri‐conception would optimize reproductive and foetal responses. Thirty‐four Anglo‐Nubian crossbred adult goats were allocated into three groups: control (n = 11), fed with a total mixed ration (TMR) based on chopped elephant grass and concentrate; HFBM (n = 11), given TMR supplemented with soybean oil on a 0.5% dry matter basis for 11 days starting nine days before mating (BM); and HFAM (n = 12), fed with soybean oil included in the TMR for 15 days after mating (AM). The TMR diets differed in their fat content (7.5% vs. 2.9%). All goats had oestrus synchronized for 14 days BM by intravaginal administration of 60 mg MPA sponge for 12 days. Forty‐eight hours BM, the sponge was removed and 0.075 mg PGF2α was applied intramuscularly. After 36 h, 1 ml GnRH was administered intramuscularly, and goats were mated after sponge removal. The fat groups showed lower feed intake (p < .001) and higher cholesterol levels (p < .001) when HFD was administered. Doppler and B‐mode ultrasound evaluations revealed a greater (p < .05) number of small (<3 mm, 10 ± 0.6 vs. 8 ± 0.5) and large (≥3 mm, 6 ± 0.4 vs. 5.0 ± 0.2) follicles and intraovarian blood area (p < .05) in the HFBM group during sponge removal (57.6%) and mating (24.2%) than those of the no‐fat group. During AM, the fat‐fed groups exhibited higher glutathione peroxidase levels (p < .05) and a reduction (p < .001) in corpus luteum size (19%) and vascularized Doppler area (41%). No difference (p > .05) between groups was found in foetal traits, placentome and umbilical vascular development, except for the embryonic vesicle where HFAM twin pregnancy showed a smaller size than the control (26.1 ± 3.5 cm vs. 33.7 ± 2.7 cm; p < .01). Thus, HFD applied during peri‐conception of goats has no impact on later foetal development but improved the follicular growth when given before the mating. Thus, the use of HFD in periconception has no impact on foetal development but increases follicular growth before breeding time.

show abstract

Linseed supplementation during uterine and early post-natal life markedly affects fatty acid profiles of brain, liver and muscle of lambs

Cited by 5 publications

References 76 publications

Enrichment of Brain n-3 Docosapentaenoic Acid (DPA) and Retinal n-3 Eicosapentaenoic Acid (EPA) in Lambs Fed Nannochloropsis oceanica Microalga

Enrichment of Brain n-3 Docosapentaenoic Acid (DPA) and Retinal n-3 Eicosapentaenoic Acid (EPA) in Lambs Fed Nannochloropsis oceanica Microalga

Fortification of diets with omega-3 long-chain polyunsaturated fatty acids enhances feedlot performance, intramuscular fat content, fat melting point, and carcass characteristics of Tattykeel Australian White MARGRA lambs

Effect of peri‐conception high‐fat diets on maternal ovarian function, foetal and placentome growth, and vascular umbilical development in goats

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