Linseed Oil Nanoemulsions for treatment of Atopic Dermatitis disease: Formulation, characterization, in vitro and in silico evaluations

Kildaci, Ilke; Budama‐Kilinc, Yasemin; Kecel‐Gunduz, Serda; Altuntaş, Ebru

doi:10.1016/j.jddst.2021.102652

Cited by 23 publications

(18 citation statements)

References 91 publications

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“…However, according to our findings, changes in electrical conductivity do not seem to affect the character and droplet size of nanoemulsions, since the increase in conductivity was insufficient to evaluate emulsion stability. In a study, it was emphasized that nanoemulsions prepared using linseed oil had high conductivity values (81.9 ± 0.035 μs/cm and 224 ± 7.830 μs/cm) and the outer phase of the nanoemulsions were water [39] . This study‘s results supported that the nanoemulsions prepared in our study were O/W type.…”

Section: Resultssupporting

confidence: 85%

Optimization and Bioactive Properties of Nanoemulsion Formulated with Hemp (Cannabis sativa L.) Seed Oil and Aloe vera (Barbadensis miller Stockton) Gel

Kara,

Caglak,

Karsli

2024

ChemistrySelect

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The use of nanoemulsions, a nanotechnology technique, is very popular in the food industry to extend the shelf life of foods and preserve their quality. In this study, it was aimed to develop, optimize, and determine the bioactive properties of nanoemulsion containing Aloe vera gel (AVG) and hemp seed oil (HSO) for use in the food industry. Nanoemulsions containing different ratios of AVG (1 %, 2 %, and 3 %) and HSO: Tween 80(T80) (1 : 4; 20, 25, 30 %) were formulated by ultrasonication. Bioactive properties of nanoemulsions were determined by droplet size, polydispersity index (PDI), zeta potential, Transmission electron microscopy (TEM) imaging, Fourier transform infrared spectroscopy (FT‐IR), viscosity, color, whiteness index, turbidity, conductivity, pH, antioxidant (DPPH), and antimicrobial activity analyses. The pH of the nanoemulsions was between 4.74 and 4.88 due to the acidic nature of AVG. PDI was determined in the 0.17 (HA8) range to 0.26 (HA1). According to the FT‐IR spectrum, it was determined that the entire nanoemulsion formulation did not undergo any chemical degradation and their particle sizes (range between 118.9 nm and 170.5 nm) were <200 nm. The small droplet size and PDI values obtained showed that the nanoemulsions had a homogeneous and stable structure in their dispersions. TEM results determined that all nanoemulsions showed a spherical shape, but the structure detected in the HA8 group had a more homogeneous appearance. The antioxidant activity of the nanoemulsions increased depending on the increasing HSO and AVG percentages. Unfortunately, no antibacterial activity of the nanoemulsions was detected against any of the bacterial strains tested. According to the analysis results, it was determined that the best nanoemulsion formulation belonged to the HA8 group containing 3 % Aloe vera gel and 5 % HSO in terms of TEM and PDI analyses.

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Section: Resultssupporting

confidence: 85%

Optimization and Bioactive Properties of Nanoemulsion Formulated with Hemp (Cannabis sativa L.) Seed Oil and Aloe vera (Barbadensis miller Stockton) Gel

Kara,

Caglak,

Karsli

2024

ChemistrySelect

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“…It has no mutagenic effect on Salmonella typhimurium strains TA98 and TA100. LSO has been identified as a possible therapeutic candidate for the treatment of Atopic dermatitis based on molecular docking and ADMET calculations 49 …”

Section: Resultsmentioning

confidence: 99%

Herbal nanocosmecuticals: A review on cosmeceutical innovation

Vaishampayan

Rane

2022

J of Cosmetic Dermatology

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Background: Cosmeceuticals are drugs, cosmetics, or a combination of both.Cosmeceuticals are personal care products that not only beautify but also need to have healing, therapeutic, and disease-fighting characteristics. For decades, phytocompounds have been employed in cosmeceuticals and have shown potential in applications such as moisturizing, sunscreen, antiaging, and hair-based therapy. The inability of phytocompounds to easily penetrate through the skin and their instability limit their usage in cosmetic products. This can be overcome by incorporating nanotechnology into cosmetic products for a more stable and long-lasting release.Nanotechnology's substantial impact on the cosmetics industry is due to the improved properties attained by particles at the nano scale, such as color, solubility, and transparency. Liposomes, solid lipid nanoparticles, niosomes, and many varieties of nanoparticulate systems are commonly used in cosmetics. Safety concerns for the usage of nanomaterials in cosmeceuticals have been raised lately, hence causing the restriction on the use of nanomaterials by cosmetic companies and enforcing laws demanding thorough safety testing prior to market entry.Aim: This review focuses on the types of nanomaterials used in phytocosmetics, along with the potential hazards they pose to human life and the environment, and what legislation has been enacted or can be enacted to address them. Methods:For relevant literature, a literature search was conducted using PubMed, ScienceDirect, and Google Scholar. Nanotechnology, cosmeceuticals, herbal cosmetics, and other related topics were researched and evaluated in articles published between 2016 and 2022.Results: Herbal drugs provide a tremendous range of therapeutic benefits. And when nanoparticles were introduced to the personal care industry, the quality of the final product containing phyto-compounds continued to rise. Unfortunately, because these nano components can permeate intact skin barriers and create unwanted consequences, this revolution comes with a slew of health risks. Conclusion:The cosmeceutical industry's expansion and growth in the application of herbal compounds, as well as the entrance of nanotechnology into the cosmeceuticals business, entail the urgent need for scientific research into their efficacy, safety profile, and use.

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“…From the findings, it was suggested that these LSO-NEs possessed high cellular and dermal permeability. Also, the topical application of these formulations could be proved as a potential therapy in the cure of AD . Almawash et al coloaded levocetirizine dihydrochloride and fluticasone propionate in a microemulsion formulation for AD treatment.…”

Section: Treatment Approaches For Various Disorders Using Topical Dru...mentioning

confidence: 99%

New Insights in Topical Drug Delivery for Skin Disorders: From a Nanotechnological Perspective

et al. 2023

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Skin, the largest organ in humans, is an efficient route for the delivery of drugs as it circumvents several disadvantages of the oral and parenteral routes. These advantages of skin have fascinated researchers in recent decades. Drug delivery via a topical route includes moving the drug from a topical product to a locally targeted region with dermal circulation throughout the body and deeper tissues. Still, due to the skin's barrier function, delivery through the skin can be difficult. Drug delivery to the skin using conventional formulations with micronized active components, for instance, lotions, gels, ointments, and creams, results in poor penetration. The use of nanoparticulate carriers is one of the promising strategies, as it provides efficient delivery of drugs through the skin and overcomes the disadvantage of traditional formulations. Nanoformulations with smaller particle sizes contribute to improved permeability of therapeutic agents, targeting, stability, and retention, making nanoformulations ideal for drug delivery through a topical route. Achieving sustained release and preserving a localized effect utilizing nanocarriers can result in the effective treatment of numerous infections or skin disorders. This article aims to evaluate and discuss the most recent developments of nanocarriers as therapeutic agent vehicles for skin conditions with patent technology and a market overview that will give future directions for research. As topical drug delivery systems have shown great preclinical results for skin problems, for future research directions, we anticipate including in-depth studies of nanocarrier behavior in various customized treatments to take into account the phenotypic variability of the disease.

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Linseed Oil Nanoemulsions for treatment of Atopic Dermatitis disease: Formulation, characterization, in vitro and in silico evaluations

Cited by 23 publications

References 91 publications

Optimization and Bioactive Properties of Nanoemulsion Formulated with Hemp (Cannabis sativa L.) Seed Oil and Aloe vera (Barbadensis miller Stockton) Gel

Optimization and Bioactive Properties of Nanoemulsion Formulated with Hemp (Cannabis sativa L.) Seed Oil and Aloe vera (Barbadensis miller Stockton) Gel

Herbal nanocosmecuticals: A review on cosmeceutical innovation

New Insights in Topical Drug Delivery for Skin Disorders: From a Nanotechnological Perspective

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