Linoleic acid: Between doubts and certainties

Choque, Benjamin; Catheline, Daniel; Rioux, Vincent; Legrand, Philippe

doi:10.1016/j.biochi.2013.07.012

Cited by 150 publications

(119 citation statements)

References 72 publications

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“…34 PUFA, besides being endogenous mediators of cell signaling and being involved in regulating gene expression, are also precursors of eicosanoids, such as prostaglandins and leukotrienes, as well as docosanoids as protectins or resolvins. 33 a-Tocopherol was the most abundant tocopherol in A. montana, which is also found in the isoforms g-and d-; Table 4. Tocopherols are very important natural antioxidants and can be used to delay rancidity in fatty materials in manufactured foods; they may also reduce the effects of aging and help to prevent oxidative stress-related diseases such as cancer, neurodegenerative and heart diseases.…”

Section: Composition In Lipophilic Compoundsmentioning

confidence: 94%

Bioactivity and phytochemical characterization of Arenaria montana L.

et al. 2014

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The bioactivity (antioxidant and cytotoxic activities) of the aqueous and methanolic extracts of Arenaria montana L., a plant commonly used in Portuguese folk medicine, was evaluated and compared.Furthermore, the phytochemical composition was determined based on hydrophilic (sugars, organic acids and phenolic compounds) and lipophilic (fatty acids and tocopherols) compounds, in order to valorize this plant material as a functional food/nutraceutical. Fructose, oxalic acid, methyl-luteolin 2 00 -O-feruloylhexosyl-C-hexoside, a-tocopherol, and linoleic acid were the main individual compounds found in A. montana. In general, the aqueous extract showed higher antioxidant and cytotoxic activities than the methanolic extract; the latter showed activity only against HeLa and HepG2 cell lines. Both aqueous and methanolic extracts showed some hepatotoxicity but at higher doses than the ones active for tumor cell lines. Moreover, the aqueous extract of A. montana may be used as a functional food or nutraceutical due to the high antioxidant and cytotoxic activities, and due to the presence of bioactive compounds. As far as we know, this is the first report on the phytochemical composition and bioactivity of A. montana.

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Section: Composition In Lipophilic Compoundsmentioning

confidence: 94%

Bioactivity and phytochemical characterization of Arenaria montana L.

et al. 2014

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“…Some studies demonstrated that LA is also a direct precursor of oxidized LA metabolites (OXLAMs) [36,70,71]. Proinflammatory properties of the OXLAMs have also been reported in rats [15,72].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Excessive dietary linoleic acid induces proinflammatory markers in rats

Marchix

Choque

Kouba

et al. 2015

The Journal of Nutritional Biochemistry

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“…However, because animal FADS proteins have never successfully been purified despite some attempts (Okayasu et al, 1981), little is known about the structureguiding principle underlying substrate specificity and regio-selectivity of the inserted double bond. Considering the FADS2 substrates with 18 carbons, it is however known for long that 6-desaturase affinity increases from oleic acid (18:1 n-9) to linoleic acid (18:2 n-6) and again to -linolenic acid (18:3 n-3) (Brenner and Peluffo, 1966), with a great impact of this substrate competition on the conversion of dietary (n-6) and (n-3) precursors to their longer highly unsaturated derivatives (Choque et al, 2014). These data suggest the importance of both the number (1, 2 or 3) of preexisting double bonds and the position (n-9, n-6 and n-3) of the methyl-terminal double bond in these 18-carbon chain FA substrates.…”

Section: Introductionmentioning

confidence: 99%