Linoleic acid and the pathogenesis of obesity

Naughton, Shaan; Mathai, Michael L.; Hryciw, Deanne H.; McAinch, Andrew J.

doi:10.1016/j.prostaglandins.2016.06.003

Cited by 109 publications

(68 citation statements)

References 119 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, the pro-inflammatory effects of C18:2n6 have been associated to the arachidonic acid-mediated eicosanoid biosynthesis (for ref. see 56), which result in molecules production, including prostaglandin E2 (57).…”

Section: Discussionmentioning

confidence: 99%

Impact of physical exercise on visceral adipose tissue fatty acid profile and inflammation in response to a high-fat diet regimen

Rocha-Rodrigues

Rodríguez

Gonçalves

et al. 2017

The International Journal of Biochemistry & Cell Biology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Impact of physical exercise on visceral adipose tissue fatty acid profile and inflammation in response to a high-fat diet regimen

Rocha-Rodrigues

Rodríguez

Gonçalves

et al. 2017

The International Journal of Biochemistry & Cell Biology

View full text Add to dashboard Cite

“…Interestingly, previous studies have demonstrated that dietary conjugated linoleic acid reduces weight gain and fat mass in rodents, although there have been conflicting reports on its effects in humans 26 . Recent studies also show that excessive linoleic acid intake may contribute to chronic inflammation in obese patients 27 . The Sham and VSG mice we used here were fed with the same diet and food intake was similar between the two groups for a majority of the time after surgery 12 .…”

Section: Discussionmentioning

confidence: 99%

Vertical sleeve gastrectomy reverses diet-induced gene-regulatory changes impacting lipid metabolism

Tian

Ding

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Vertical sleeve gastrectomy (VSG) produces sustainable weight loss, remission of type 2 diabetes (T2D), and improvement of nonalcoholic fatty liver disease (NAFLD). However, the molecular mechanisms underlying the metabolic benefits of VSG have remained elusive. According to our previous results, diet-induced obesity induces epigenetic modifications to chromatin in mouse liver. We demonstrate here that VSG in C57BL/6J wild-type male mice can reverse these chromatin modifications and thereby impact the expression of key metabolic genes. Genes involved in lipid metabolism, especially omega-6 fatty acid metabolism, are up-regulated in livers of mice after VSG while genes in inflammatory pathways are down-regulated after VSG. Consistent with gene expression changes, regulatory regions near genes involved in inflammatory response displayed decreased chromatin accessibility after VSG. Our results indicate that VSG induces global regulatory changes that impact hepatic inflammatory and lipid metabolic pathways, providing new insight into the mechanisms underlying the beneficial metabolic effects induced by VSG.

show abstract

“…A recent review of linoleic acid’s role in inflammation and the pathogenesis of obesity discusses this approach of lowering linoleic acid intake to reduce inflammatory effects [16]. In addition, Liou et al reported that reducing linoleic acid intake in men increased the level of n-3 eicosapentaenoic acid in plasma phospholipids in men [17].…”

Section: Inflammationmentioning

confidence: 99%

Linoleic Acid: A Nutritional Quandary

Jandacek

2017

Healthcare

125

View full text Add to dashboard Cite

Over the course of the twentieth century, there was a 20-fold increase in consumption of vegetable oils resulting both from their increased availability and from recommendations to consume these oils as an aid to lower blood cholesterol levels. This dietary change markedly increased the consumption of linoleic acid to current levels of approximately 6% of total dietary energy. While considerable research has focused on the effects of dietary linoleic acid on cardiovascular health, questions about optimum dietary levels remain. For example, meta-analyses disagree about the role of dietary linoleic acid in atherosclerosis, and recent publications indicate that linoleic acid’s reduction of blood cholesterol levels does not predict its effect on the development of atherosclerosis. Further, there are also detrimental effects of elevated dietary linoleic acid on human health related to its role in inflammation and its activity as a promoter of cancer in animals. Current data do not allow determination of the level of dietary linoleic acid needed for optimum health. Studies of the effects of a wide range of linoleic acid consumption may help determine dietary recommendations that are optimal for human health.

show abstract

Linoleic acid and the pathogenesis of obesity

Cited by 109 publications

References 119 publications

Impact of physical exercise on visceral adipose tissue fatty acid profile and inflammation in response to a high-fat diet regimen

Impact of physical exercise on visceral adipose tissue fatty acid profile and inflammation in response to a high-fat diet regimen

Vertical sleeve gastrectomy reverses diet-induced gene-regulatory changes impacting lipid metabolism

Linoleic Acid: A Nutritional Quandary

Contact Info

Product

Resources

About