Linoleic acid and risk of sudden cardiac death.

Roberts, Timothy L.; Wood, D.A.; Riemersma, R.A.; Gallagher, Peggy A.; Lampe, Fiona

doi:10.1136/hrt.70.6.524

Cited by 40 publications

(11 citation statements)

References 14 publications

(3 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…16 These findings are in agreement with experimental evidence in animals that omega-3 fatty acids reduce the vulnerability of the ischemic myocardium to ventricular fibrillation. 44 -46 Our patients were admitted to coronary care units.…”

Section: Discussionsupporting

confidence: 86%

“…[7][8][9][10][11][12] Similarly, studies of the association of plasma or tissue levels of fish oils and incidence of myocardial infarction have yielded conflicting results. [13][14][15][16][17] A randomized trial of diet in patients after myocardial infarction found a significant reduction in mortality caused by ischemic heart disease in the group assigned to consuming fatty fish 2 to 3 times per week, but the number of ischemic events was not reduced. 18 ALA may also reduce platelet aggregability, 19 -21 either by modulating the effect of arachidonic acid, 22,23 or through desaturation and elongation to EPA.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Omega-3 Fatty Acids in Adipose Tissue and Risk of Myocardial Infarction

Güallar

Aro

Jiménez

et al. 1999

ATVB

140

View full text Add to dashboard Cite

Abstract-Omega-3 fatty acids have potential antiatherogenic, antithrombotic, and antiarrhythmic properties, but their role in coronary heart disease remains controversial. To evaluate the association of omega-3 fatty acids in adipose tissue with the risk of myocardial infarction in men, a case-control study was conducted in eight European countries and Israel. Cases (nϭ639) included patients with a first myocardial infarction admitted to coronary care units within 24 hours from the onset of symptoms. Controls (nϭ700) were selected to represent the populations originating the cases. Adipose tissue levels of fatty acids were determined by capillary gas chromatography. The mean (ϮSD) proportion of ␣-linolenic acid was 0.77% (Ϯ0.19) of fatty acids in cases and 0.80% (Ϯ0.19) of fatty acids in controls (Pϭ0.01). The relative risk for the highest quintile of ␣-linolenic acid compared with the lowest was 0.42 (95% confidence interval [CI] 0.22 to 0.81, P-trendϭ0.02). After adjusting for classical risk factors, the relative risk for the highest quintile was 0.68 (95% CI 0.31 to 1.49, P-trendϭ0.38). The mean proportion of docosahexaenoic acid was 0.24% (Ϯ0.13) of fatty acids in cases and 0.25% (Ϯ0.13) of fatty acids in controls (Pϭ0.14), with no evidence of association with risk of myocardial infarction. In this large case-control study we could not detect a protective effect of docosahexaenoic acid on the risk of myocardial infarction. The protective effect of ␣-linolenic acid was attenuated after adjusting for classical risk factors (mainly smoking), but it deserves further research.

show abstract

Section: Discussionsupporting

confidence: 86%

mentioning

confidence: 99%

Omega-3 Fatty Acids in Adipose Tissue and Risk of Myocardial Infarction

Güallar

Aro

Jiménez

et al. 1999

ATVB

140

View full text Add to dashboard Cite

show abstract

“…The most striking change on the walnut diet was the increase in linoleic acid in all plasma fatty acid fractions and the increase in alpha linolenic acid in plasma triacylglycerol. There is reasonably convincing evidence that linoleic acid may be protective against CHD (Riemersma et al, 1986;Hetzel et al, 1989;Roberts et al, 1993) and there is emerging evidence of the importance of dietary alpha linolenic acid.…”

Section: Discussionmentioning

confidence: 99%

A diet rich in walnuts favourably influences plasma fatty acid profile in moderately hyperlipidaemic subjects

et al. 1998

View full text Add to dashboard Cite

Objective: To compare two low fat diets one rich in walnuts on parameters of lipid metabolism in a group of hyperlipidaemic subjects. Design: A randomised cross over study. Setting: Department of Human Nutrition, University of Otago, Dunedin, New Zealand Subjects: Twenty one men with mean (s.d) levels of total and LDL cholesterol of 6.58 (0.60) and 4.63 (0.58) respectively. Interventions: For two periods of four weeks subjects were asked to consume two low fat diets (fat 30% total energy), one containing, on average, 78 gad walnuts. Walnuts obtained through Lincoln University and the Walnut Growers Group (South Canterbury). Results: Participants reported a higher total fat intake on the walnut diet (38% compared with 30% on the low fat diet P`0.01) The most consistent change in fatty acid pro®le of triacylglycerol, phospholipid and cholesterol ester on the walnut diet was a signi®cant (P`0.01) increase in linoleic acid. Triacylglycerol linolenate also increased signi®cantly (P`0.01). Total and LDL cholesterol were lower on both experimental diets than at baseline, 0.25 mmolal and 0.36 mmolal respectively on the walnut diet and 0.13 mmolal and 0.20 mmolal respectively on the low fat diet. High density lipoprotein cholesterol was higher on both the walnut and low fat diets when compared to baseline (0.15 mmolal and 0.12 mmolal, respectively). When comparing the walnut and low fat diets only apo B was signi®cantly lower (P`0.05) on the walnut diet. Conclusions: Despite an unintended increase in the total fat intake on the walnut diet, fatty acid pro®le of the major lipid fractions showed changes which might be expected to reduce risk of cardiovascular disease. The reduction of apolipoprotein B suggests a reduction in lipoprotein mediated risk, the relatively low myristic acid content of both diets perhaps explaining the absence of more extensive differences in lipoprotein levels on the two diets.

show abstract

“…Those in vestigations revealed that a highly saturated fatty acid concentration in fat tissue is corre 124 C'han/Tsai/Chiang/Hong Trilinolein and Coronary Ligation lated with a high incidence rate of ventricular arrhythmia in patients with acute myocardial infarction [27], Also an inverse relation oc curs between linoleic acid and the risk of angi na and of sudden cardiac death [28,29], In animal studies, mortality and severity of ar rhythmia following coronary ligation were found to be reduced in animals fed with a linoleic acid-rich diet [7,8,30]. Results here are compatible with those reports which claimed a beneficial effect from such a diet.…”

Section: Discussionmentioning

confidence: 99%

Trilinolein Reduces Infarct Size and Suppresses Ventricular Arrhythmias in Rats Subjected to Coronary Ligation

et al. 1995

View full text Add to dashboard Cite

Trilinolein, a triacylglycerol with linoleic acid as the only fatty acid residue in all esterified positions of glycerol, was previously found to improve erythrocyte deformability in vitro. In this study, the in vivo antiarrhythmic and anti-ischemic effects of trilinolein in coronary ligated rats were investigated. Male Sprague-Dawley rats were anesthetized with urethane. Trilinolein, at dosages ranging from 10–¹¹ to 10^–7 g/kg, was administered intravenously 15 min before ligation of coronary artery. Also, the effect of trilinolein on arrhythmia was studied by ligating the coronary artery for 30 min, then reperfusing myocardium for 10 min. During the 30-min ischemia, trilinolein reduced not only the number of ectopic beats but also the incidence rate and duration of ventricular tachycardia. At 10–⁷ g/kg, trilinolein completely suppressed all ventricular arrhythmias. Ventricular arrhythmias during 10 min reperfusion were also reduced by trilinolein at similar dosages. Furthermore, the effect of trilinolein on infarct size was evaluated by occluding the coronary artery for 4 h before the infarct zone was stained and weighed. In rats subjected to 4 h coronary ligation, pretreatment with 10–⁷ g/kg trilinolein at 15 min prior to the coronary ligation significantly reduced infarct size. Trilinolein may protect myocardium against ischemic injury and suppress arrhythmia during ischemia and reperfusion.

show abstract

Linoleic acid and risk of sudden cardiac death.

Cited by 40 publications

References 14 publications

Omega-3 Fatty Acids in Adipose Tissue and Risk of Myocardial Infarction

Omega-3 Fatty Acids in Adipose Tissue and Risk of Myocardial Infarction

A diet rich in walnuts favourably influences plasma fatty acid profile in moderately hyperlipidaemic subjects

Trilinolein Reduces Infarct Size and Suppresses Ventricular Arrhythmias in Rats Subjected to Coronary Ligation

Contact Info

Product

Resources

About