Linoleic Acid

Whelan, Jay; Fritsche, Kevin L.

doi:10.3945/an.113.003772

Cited by 263 publications

(204 citation statements)

References 8 publications

Supporting

Mentioning

178

Contrasting

Unclassified

Order By: Relevance

“…LA biosynthesis and metabolism requires some of the same enzymes used for EPA synthesis and metabolism, including the production of downstream metabolites 32,33 . Moreover, LA's consumption in the western diet is [14][15][16][17][18] times the amount required to prevent LA deficiency 22,46 and LA's effects on insulin sensitivity are strongly debated [46][47][48][49][50][51][52][53] .…”

Section: Discussionmentioning

confidence: 99%

Resolvin E1 derived from eicosapentaenoic acid prevents hyperinsulinemia and hyperglycemia in a host genetic manner

Pal

Al-Shaer

Guesdon

et al. 2019

Preprint

View full text Add to dashboard Cite

The insulin/glucose-sensitizing properties of specialized pro-resolving mediators (SPMs) are emerging. We investigated the role of resolvin E1 (RvE1) and its parent molecule eicosapentaenoic acid (EPA) on insulin/glucose homeostasis. We first identified a decrease in the RvE1 precursor 18-hydroxyeicosapentaenoic acid in obese male C57BL/6J mice. Therefore, we investigated the effects of intraperitoneal administration of exogenous RvE1 on obese inbred and outbred male mice. RvE1 administered to obese C57BL/6J mice for just four days improved hyperglycemia and hyperinsulinemia, which was partially dependent on the receptor ERV1/ChemR23. In contrast, RvE1's effects on fasting insulin/glucose were divergent in diversity outbred mice modeling human genetic variation. Next, we studied the preventative effects of pure dietary EPA ethyl esters on obese C57BL/6J mice. EPA ameliorated obesity-induced glucose intolerance, hyperinsulinemia, and hyperglycemia and this was independent from remodeling of the gut microbiome. Supporting analyses of NHANES data revealed that glucose levels were inversely related with EPA intake in obese adults in a sex-specific manner. Finally, secondary SNP analyses revealed extensive genetic variation of human EPA-and RvE1metabolizing genes. Collectively, the data underscore the importance of the resolvin E1-EPA axis in controlling insulin/glucose homeostasis and point to a therapeutic role for RvE1 that depends on the host genome.

show abstract

Section: Discussionmentioning

confidence: 99%

Resolvin E1 derived from eicosapentaenoic acid prevents hyperinsulinemia and hyperglycemia in a host genetic manner

Pal

Al-Shaer

Guesdon

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…Linoleic acid (LA) is an essential fatty acid, mainly derived from vegetable oils, seeds, nuts, meats, and eggs1 and is the most widely consumed polyunsaturated fatty acid in the human diet. Most previous long‐term follow‐up studies on stroke have been based on self‐reported dietary intake of LA and were consequently affected by measurement error.…”

Section: Introductionmentioning

confidence: 99%

Linoleic Acid in Adipose Tissue and Development of Ischemic Stroke: A Danish Case‐Cohort Study

Venø

Bork

Jakobsen

et al. 2018

JAHA

View full text Add to dashboard Cite

BackgroundWe investigated the association between the content of linoleic acid in adipose tissue, a biomarker of long‐term intake of linoleic acid, and the risk of ischemic stroke and its subtypes.Methods and ResultsThe Danish cohort study Diet, Cancer and Health included 57 053 patients aged 50 to 65 years at enrollment. All participants had an adipose tissue biopsy performed at enrollment, while information on ischemic stroke during follow‐up was obtained from the Danish National Patient Register. Stroke diagnoses were all validated and classified according to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification. Cases and a randomly drawn subcohort of 3500 patients had their fatty acid composition in adipose tissue determined by gas chromatography. Hazard ratios with 95% confidence intervals were calculated using weighted Cox proportional hazard regression. During 13.5 years of follow‐up, 1879 ischemic stroke cases were identified, for which 1755 adipose biopsies were available, while adipose biopsies were available for 3203 participants in the subcohort. When comparing the highest and the lowest quartiles of adipose tissue content of linoleic acid there was a negative association with the rate of total ischemic stroke (hazard ratio, 0.78; 95% confidence interval, 0.65–0.93) and large artery atherosclerosis (hazard ratio, 0.61; 95% confidence interval, 0.43–0.88), while there was an indication of a negative association with small‐vessel occlusion (hazard ratio, 0.87; 95% confidence interval, 0.69–1.11). There was no clear association with the rate of cardioembolism.ConclusionsThe content of linoleic acid in adipose tissue was inversely associated with the risk of total ischemic stroke and stroke caused by large artery atherosclerosis.

show abstract

“…AA has a major role in development especially of the CNS and retina . AA can be metabolized into prostaglandin (PGE2) and leukotriene (LTB4) that can contribute to inflammation when produced in excess . AA is also the precursor of endocannabinoids, 2‐arachidonoylglycerol (2‐AG) and anandamide …”

Section: Polyunsaturated Fatty Acids In the Dietmentioning

confidence: 99%

“…24 AA can be metabolized into prostaglandin (PGE2) and leukotriene (LTB4) that can contribute to inflammation when produced in excess. 25 AA is also the precursor of endocannabinoids, 2-arachidonoylglycerol (2-AG) and anandamide. 26 n-3 LCPUFAs have been reported to be beneficial to health as they possess anti-inflammatory and antithrombotic effects.…”

Section: P Oly Un Satur Ated Fat T Y Acids In the D Ie Tmentioning

confidence: 99%

Role of omega‐6 and omega‐3 fatty acids in fetal programming

Shrestha

Sleep

Cuffe

et al. 2020

Clin Exp Pharma Physio

View full text Add to dashboard Cite

Maternal nutrition plays a critical role in fetal development and can influence adult onset of disease. Linoleic acid (LA) and alpha‐linolenic acid (ALA) are major omega‐6 (n‐6) and n‐3 polyunsaturated fatty acids (PUFA), respectively, that are essential in our diet. LA and ALA are critical for the development of the fetal neurological and immune systems. However, in recent years, the consumption of n‐6 PUFA has increased gradually worldwide, and elevated n‐6 PUFA consumption may be harmful to human health. Consumption of diets with high levels of n‐6 PUFA before or during pregnancy may have detrimental effects on fetal development and may influence overall health of offspring in adulthood. This review discusses the role of n‐6 PUFA in fetal programming, the importance of a balance between n‐6 and n‐3 PUFAs in the maternal diet, and the need of further animal models and human studies that critically evaluate both n‐6 and n‐3 PUFA contents in diets.

show abstract

Linoleic Acid

Cited by 263 publications

References 8 publications

Resolvin E1 derived from eicosapentaenoic acid prevents hyperinsulinemia and hyperglycemia in a host genetic manner

Resolvin E1 derived from eicosapentaenoic acid prevents hyperinsulinemia and hyperglycemia in a host genetic manner

Linoleic Acid in Adipose Tissue and Development of Ischemic Stroke: A Danish Case‐Cohort Study

Role of omega‐6 and omega‐3 fatty acids in fetal programming

Contact Info

Product

Resources

About