Linoleate and fatty acid compositions in the serum lipids of Japanese patients with multiple sclerosis

Yoshida, Motoaki; Takase, Sadao; Itahara, Katsuya; Nakanishi, Takao

doi:10.1111/j.1600-0404.1983.tb04844.x

Cited by 12 publications

(4 citation statements)

References 18 publications

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“…Omega-6 essential fatty acids (EFAs) exert a crucial role in both the synthesis and metabolism of myelin. MS patients showed significantly lower mean concentration of serum linoleic acid, lymphocytes, and cerebrospinal fluid (CSF) compared to healthy individuals in most [23,24,25], but not all [26] currently available studies. CSF can show the changes on the CNS CSF analysis provides insight on the state of health of the CNS, and it can help investigate the mechanisms of CNS injury and repair [27].…”

Section: Dietary Supplements and Multiple Sclerosismentioning

confidence: 99%

Dietary Supplements on Controlling Multiple Sclerosis Symptoms and Relapses: Current Clinical Evidence and Future Perspectives

et al. 2019

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Background: Multiple sclerosis (MS) constitutes a chronic progressive demyelinating disease which negatively affects the central nervous system. MS symptoms detrimentally affect the quality of life, as well as the life expectancy of MS patients. In this aspect, the present study aims to critically summarize and evaluate the currently available clinical studies focusing on the potential beneficial effects of dietary supplements on controlling MS symptomatology and relapse. Methods: PubMed database was comprehensively searched, using relative keywords to identify clinical trials that investigated the beneficial effects of dietary supplementation against MS symptomatology and progression. 40 clinical trials were found, which were divided into categories. Results: Nutritional status of MS patients, as well as supplementation have been suggested as potential factors affecting progression. Several substantial studies have documented a systematically high prevalence of vitamin A, B12 and D3 deficiency amongst MS patients. At present, clinical data have suggested that most of the dietary supplements under study may exert antioxidant and anti-inflammatory properties, improving depression symptomatology and quality of life overall. However, malnutrition risk in MS patients has not been adequately explored in order for more precise conclusions to be drawn. The supplements that may have a positive effect on MS are vitamins, fatty acids, antioxidants, phytochemicals and melatonin. Conclusions: Several dietary supplements may decrease inflammation and fatigue, also increasing also autoimmunity tolerance in MS patients, and thus improving quality of life and life expectancy. Currently, there is no effective clinical indication for applying dietary supplementation as complementary treatment against MS symptomatology.

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Section: Dietary Supplements and Multiple Sclerosismentioning

confidence: 99%

Dietary Supplements on Controlling Multiple Sclerosis Symptoms and Relapses: Current Clinical Evidence and Future Perspectives

et al. 2019

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“…Low levels of linoleic acid (18:2w6) in lipids were reported (2)(3)(4). Other studies found little difference between MS patients and normal individuals for 18:2w6 or other FA in serum lipids (5)(6)(7)(8). One study concluded that FA patterns in MS and other illnesses resembled that of essential fatty acid (EFA) deficiency and that this may be a general phenomenon of illness (9).…”

mentioning

confidence: 99%

Deficiencies of polyunsaturated fatty acids and replacement by nonessential fatty acids in plasma lipids in multiple sclerosis.

Holman

Johnson

Kokmen

1989

Proc. Natl. Acad. Sci. U.S.A.

100

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Fatty acid compositions of plasma phospholipids, cholesteryl esters, triacylglycerols, and nonesterifiled fatty acids of 14 clinically proven and graded cases of multiple sclerosis were determined by capillary gas chromatography and compared with the values obtained for 100 normal, healthy subjects. In phospholipids, linoleic acid (18:2to6; 18 carbon atoms, 2 double bonds, 6 carbon atoms beyond last double bond) was normal and 18:3w6 was increased, but all subsequent w6 acids were subnormal (P < 0.001), indicating impairment of chain elongation. All W3 acids were subnormal. The paucity of polyunsaturated fatty acids was compensated mass-wise by an increase in saturated acids. Disproportionate increases in short-chain, saturated, and monounsaturated acids, decreases in long-chain homologs, and increases of branched and odd-chain acids were observed. Loss of polyunsaturated fatty acids and replacement by nonessential acids lowered mean chain length and raised mean melting point significantly, suggesting that lowered membrane fluidity was only partially compensated by endogenous synthesis of lowermelting, nonessential acids. This phenomenon was not observed in cholesteryl esters or triacylglycerols. Nonesterified fatty acids showed significant changes in pattern of possible autacoid precursors. The abnormal profile of fatty acids in multiple sclerosis has features in common with prorfles of other syndromes involving viral infections.

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“…The mean concentration of linoleic acid in serum, serum lipids, lymphocytes, and cerebrospinal fluid was significantly lower in patients with MS than in controls in most, 27 - 32 but not all, 33 studies. The reduced concentrations of linoleic acid may be due in part to malabsorption, since 42% of 52 MS patients were found in one study to have increased fecal fat excretion.…”

Section: Nutritional Supplementsmentioning

confidence: 79%

“…In guinea pigs, supplementation with linoleic acid decreased the severity of experimental allergic encephalomyelitis when the disease was mild or moderate but not when it was severe. 26 The mean concentration of linoleic acid in serum, serum lipids, lymphocytes, and cerebrospinal fluid was significantly lower in patients with MS than in controls in most, [27][28][29][30][31][32] but not all, 33 studies. The reduced concentrations of linoleic acid may be due in part to malabsorption, since 42% of 52 MS patients were found in one study to have increased fecal fat excretion.…”

Section: Omega-6 Fatty Acidsmentioning

confidence: 95%

Multiple Sclerosis

Gaby¹

2013

Glob Adv Health Med

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Multiple sclerosis (MS) is a chronic progressive demyelinating disease of the central nervous system. Common manifestations include paresthesias, diplopia, loss of vision, numbness or weakness of the limbs, bowel or bladder dysfunction, spasticity, ataxia, fatigue, and mental changes. Four main patterns of MS are recognized: relapsing remitting, primary progressive, secondary progressive, and progressive relapsing. The cause of MS is unknown, although it appears to be an autoimmune disease. Much of what is known about MS has been learned from an animal model of the disease, experimental allergic encephalomyelitis.

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Linoleate and fatty acid compositions in the serum lipids of Japanese patients with multiple sclerosis

Cited by 12 publications

References 18 publications

Dietary Supplements on Controlling Multiple Sclerosis Symptoms and Relapses: Current Clinical Evidence and Future Perspectives

Dietary Supplements on Controlling Multiple Sclerosis Symptoms and Relapses: Current Clinical Evidence and Future Perspectives

Deficiencies of polyunsaturated fatty acids and replacement by nonessential fatty acids in plasma lipids in multiple sclerosis.

Multiple Sclerosis

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