Links between Inflammation and Postoperative Cancer Recurrence

Abstract

Despite complete resection, cancer recurrence frequently occurs in clinical practice. This indicates that cancer cells had already metastasized from their organ of origin at the time of resection or had circulated throughout the body via the lymphatic and vascular systems. To obtain this potential for metastasis, cancer cells must undergo essential and intrinsic processes that are supported by the tumor microenvironment. Cancer-associated inflammation may be engaged in cancer development, progression, and metastasis. Despite numerous reports detailing the interplays between cancer and its microenvironment via the inflammatory network, the status of cancer-associated inflammation remains difficult to recognize in clinical settings. In the current paper, we reviewed clinical reports on the relevance between inflammation and cancer recurrence after surgical resection, focusing on inflammatory indicators and cancer recurrence predictors according to cancer type and clinical indicators.

Transcriptome sequencing analysis for the identification of stable lncRNAs associated with bovine Staphylococcus aureus mastitis

“…In our analysis, only 32 DE lncRNAs were shared among the three different bovine milk-originated S. aureus strains, which reminded us that when studying host–pathogen interactions, heterogeneity between strains should be considered. The chronic inflammation engaged in the progress of cancer is widely recognized [ 36 – 38 ], and the pathways of breast cancer and basel cell carcinoma are exclusively enriched in the comparison of CL vs. CC, which implied the potential harm of strain L (isolated from a cow with low milk SCC) to the host. Moreover, previous studies reported that the host’s inflammatory response and cytokine expression level are dependent on pathogen concentration [ 39 – 41 ].…”

Postoperative hyperprogression disease of pancreatic ductal adenocarcinoma after curative resection: A retrospective cohort study.

“…Multiple studies have proposed the concept of early recurrence to characterize recurrence that occur within few months of pancreatic cancer resection; however, they did not reach an agreement on cut-off values (varying from 6 to 12 months) and ignored the certain group that might have showed relapse before the rst time of their follow-up or postoperative adjuvant therapy. The concept, hyperprogression HPD was mostly referred to in the eld of immunotherapy; however, growth-stimulating effects from surgical trauma-induced immunosuppression were also mentioned in recent studies 5,14 . The in ammatory response played a critical role in tumor invasion, progression, and metastasis by promoting tumor angiogenesis and decreasing anticancer effects 14 .…”

“…The concept, hyperprogression HPD was mostly referred to in the eld of immunotherapy; however, growth-stimulating effects from surgical trauma-induced immunosuppression were also mentioned in recent studies 5,14 . The in ammatory response played a critical role in tumor invasion, progression, and metastasis by promoting tumor angiogenesis and decreasing anticancer effects 14 . According to previous studies, systemic response to tissue damages led to surgeries and the subsequent wound healing triggered a cascade alteration in cellular immunity.…”

Regulation of histone H3 lysine 9 methylation in inflammation

“…Inflammation triggers inflammatory diseases including pulmonary diseases, Alzheimer's disease and diabetes, cancer, atopic dermatitis, arthritis, asthma, gout, psoriasis, anemia, Parkinson's disease, multiple sclerosis, and depression (Bruno et al 2020;Ahmad et al 2021;Carranza-Naval et al 2021;Choi et al 2021;Kinoshita and Goto 2021;Romano et al 2021). These diseases have become increasingly threatening to human health (Wu et al 2020;Placha and Jampilek 2021).…”