Linking the septin expression with carcinogenesis

Liu, Ming; Shen, Suqin; Chen, Fang; Yu, Wenbo; Liu, Yu

doi:10.1007/s11033-010-0009-2

Cited by 41 publications

(33 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Altered expression of additional septin family members in breast and ovarian cancer has been recently reported. SEPT4 was found to be significantly downregulated in five year relapsing estrogen positive breast carcinoma patients compared to patients with no relapse (Liu et al, 2010). This observation introduces a possible relationship between septin expression in the breast and ER signaling, as proposed with prostate cancer, thereby implying that hormones could potentially regulate septins Prostate cancer cell lines and xenografts (Amir et al, 2006) and their cellular interactions and expression in cancer.…”

Section: Hormonally Regulated Carcinomas and Septins (Prostate Ovarimentioning

confidence: 69%

Septin roles in tumorigenesis

Connolly

Abdesselam

Verdier-Pinard

et al. 2011

BCHM

View full text Add to dashboard Cite

Septins are a family of cytoskeleton related proteins consisting of 14 members that associate and interact with actin and tubulin. From yeast to humans, septins maintain a conserved role in cytokinesis and they are also involved in a variety of other cellular functions including chromosome segregation, DNA repair, migration and apoptosis. Tumorigenesis entails major alterations in these processes. A substantial body of literature reveals that septins are overexpressed, downregulated or generate chimeric proteins with MLL in a plethora of solid tumors and in hematological malignancies. Thus, members of this gene family are emerging as key players in tumorigenesis. The analysis of septins during cancer initiation and progression is challenged by the presence of many family members and by their potential to produce numerous isoforms. However, the development and application of advanced technologies is allowing for a more detailed analysis of septins during tumorigenesis. Specifically, such applications have led to the establishment and validation of SEPT9 as a biomarker for the early detection of colorectal cancer. This review summarizes the current knowledge on the role of septins in tumorigenesis, emphasizing their significance and supporting their use as potential biomarkers in various cancer types.

show abstract

Section: Hormonally Regulated Carcinomas and Septins (Prostate Ovarimentioning

confidence: 69%

Septin roles in tumorigenesis

Connolly

Abdesselam

Verdier-Pinard

et al. 2011

BCHM

View full text Add to dashboard Cite

show abstract

“…Septins were initially determined to be involved in cytokinesis and cell cycle control but more recently have been shown to have a role in microtubule-dependent processes, such as karyokinesis, exocytosis, and maintenance of cell shape (65). Both SEPT2 and SEPT9 were observed to be up-regulated in a variety of tumor types, including HCC (66). Another microtubule-associated target is vimentin (VIM), a member of the intermediate filament family.…”

Section: Table 3 Distribution Of Identified Mir-122 Targets Accordingmentioning

confidence: 99%

Two-tiered Approach Identifies a Network of Cancer and Liver Disease-related Genes Regulated by miR-122

Boutz

Collins

Suresh

et al. 2011

Journal of Biological Chemistry

View full text Add to dashboard Cite

MicroRNAs function as important regulators of gene expression and are commonly linked to development, differentiation, and diseases such as cancer. To better understand their roles in various biological processes, identification of genes targeted by microRNAs is necessary. Although prediction tools have significantly helped with this task, experimental approaches are ultimately required for extensive target search and validation. We employed two independent yet complementary high throughput approaches to map a large set of mRNAs regulated by miR-122, a liver-specific microRNA implicated in regulation of fatty acid and cholesterol metabolism, hepatitis C infection, and hepatocellular carcinoma. The combination of luciferase reporterbased screening and shotgun proteomics resulted in the identification of 260 proteins significantly down-regulated in response to miR-122 in at least one method, 113 of which contain predicted miR-122 target sites. These proteins are enriched for functions associated with the cell cycle, differentiation, proliferation, and apoptosis. Among these miR-122-sensitive proteins, we identified a large group with strong connections to liver metabolism, diseases, and hepatocellular carcinoma. Additional analyses, including examination of consensus binding motifs for both miR-122 and target sequences, provide further insight into miR-122 function. MicroRNAs (miRNAs)4 are small (20 -24 nt) endogenously expressed noncoding RNAs that regulate the translational efficiency and/or degradation of specific mRNAs. First discovered in Caenorhabditis elegans (1), miRNAs have since been identified in a diverse set of eukaryotic organisms as well as viruses, with over 700 miRNAs currently identified in humans (2). miRNAs function via the RNAi pathway, guiding the RNAinduced silencing complex to mRNAs by Watson-Crick base pairing between the miRNA and target mRNA (reviewed in Ref.3). The resulting interaction leads to translational repression of the mRNA, although how this repression is achieved remains unclear. Several mechanisms have been proposed (reviewed in Ref. 4), and many questions remain; however, it is clear that sequence complementarity lies at the heart of miRNA function. In animals, sequence complementarity between an miRNA and its target mRNA is rarely perfect. The vast majority of binding sites contain mismatches between strands, and these mismatches have been shown to play an important functional role in target repression (5, 6). Imperfect complementarity allows for a greater variability of target sequences, thus increasing the number of potential binding sites for a given miRNA, with estimates of 300 -400 targets on average per miRNA (7). Although many potential miRNA targets can be identified through predictions, no computational approach is all-inclusive, and even highly conservative predictions must be validated by experimental means to verify functional relevance.Certain miRNAs have caught the attention of scientists due to their strong connections to diseases and cancer. Such is the

show abstract

“…The abnormal expressions were in accordance with the tumour malignances or prognosis of corresponding cancer patients, implicating that septins may play an important role in carcinogenesis. It is also known that SEPT5, SEPT6, SEPT9 and SEPT11 were found mutated in infant acute leukemia patients [68]. Anillin, which interacts with septins, is also implicated in carcinogenesis.…”

Section: Mitotic Checkpoint Proteinsmentioning

confidence: 99%

Cytokinesis and cancer

Sagona

Stenmark

2010

FEBS Letters

View full text Add to dashboard Cite

a b s t r a c tCytokinesis is the final stage of cell division during which the two daughter cells separate completely. Although less well understood than some of the earlier phases of the cell cycle, recent discoveries have shed light on the mechanisms that orchestrate this process, including cleavage furrow formation, midbody maturation and abscission. One of the reasons why research on cytokinesis has been attracting increasing attention is the concept that failure of this process in mammals is associated with carcinogenesis. In this minireview, we will discuss the possible links between cytokinesis and cancer, and highlight key mechanisms that connect these processes.

show abstract

Linking the septin expression with carcinogenesis

Cited by 41 publications

References 39 publications

Septin roles in tumorigenesis

Septin roles in tumorigenesis

Two-tiered Approach Identifies a Network of Cancer and Liver Disease-related Genes Regulated by miR-122

Cytokinesis and cancer

Contact Info

Product

Resources

About