Linking structure and function: Development of lateral spatial interactions in macaque monkeys

Li, Da Peng; Hagan, Maureen A.; Kiorpes, Lynne

doi:10.1017/s0952523813000394

Cited by 8 publications

(4 citation statements)

References 62 publications

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“…In addition, they demonstrated that the spatial resolution of cells in V1 (the highest spatial frequency at which cells give a response of at least 10% of its maximum) increases from birth to adulthood. There is also a general trend for increasing surround suppression from birth to adulthood (Kiorpes and Movshon, 2003 ; Chino et al, 2004 ) and facilitation develops slowly over the first year after birth (Li et al, 2013 ). These changes in receptive field size, spatial acuity and surround suppression could plausibly be attributed to changes in the geometrical sampling of neurons as their dendritic trees change shape (Sholl, 1955 ; Ferster, 1998 ; Taylor et al, 2000 ; Taylor and Vaney, 2002 ).…”

Section: Neuronal Receptive Field Properties In Postnatal Developmentmentioning

confidence: 99%

Pyramidal cell development: postnatal spinogenesis, dendritic growth, axon growth, and electrophysiology

Elston¹,

2014

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Here we review recent findings related to postnatal spinogenesis, dendritic and axon growth, pruning and electrophysiology of neocortical pyramidal cells in the developing primate brain. Pyramidal cells in sensory, association and executive cortex grow dendrites, spines and axons at different rates, and vary in the degree of pruning. Of particular note is the fact that pyramidal cells in primary visual area (V1) prune more spines than they grow during postnatal development, whereas those in inferotemporal (TEO and TE) and granular prefrontal cortex (gPFC; Brodmann's area 12) grow more than they prune. Moreover, pyramidal cells in TEO, TE and the gPFC continue to grow larger dendritic territories from birth into adulthood, replete with spines, whereas those in V1 become smaller during this time. The developmental profile of intrinsic axons also varies between cortical areas: those in V1, for example, undergo an early proliferation followed by pruning and local consolidation into adulthood, whereas those in area TE tend to establish their territory and consolidate it into adulthood with little pruning. We correlate the anatomical findings with the electrophysiological properties of cells in the different cortical areas, including membrane time constant, depolarizing sag, duration of individual action potentials, and spike-frequency adaptation. All of the electrophysiological variables ramped up before 7 months of age in V1, but continued to ramp up over a protracted period of time in area TE. These data suggest that the anatomical and electrophysiological profiles of pyramidal cells vary among cortical areas at birth, and continue to diverge into adulthood. Moreover, the data reveal that the “use it or lose it” notion of synaptic reinforcement may speak to only part of the story, “use it but you still might lose it” may be just as prevalent in the cerebral cortex.

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Section: Neuronal Receptive Field Properties In Postnatal Developmentmentioning

confidence: 99%

Pyramidal cell development: postnatal spinogenesis, dendritic growth, axon growth, and electrophysiology

Elston¹,

2014

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“…A behavioral study of facilitation and suppression of stimulus detection by nearby stimuli [ 103 ] concluded that facilitatory lateral spatial interactions mature late, around age 1 year. Corroborating EEG data, from visual-evoked potentials [ 104 ], showed that lateral interactions are also not mature in young human infants.…”

Section: Discussionmentioning

confidence: 99%

Development of visual cortical function in infant macaques: A BOLD fMRI study

et al. 2017

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Functional brain development is not well understood. In the visual system, neurophysiological studies in nonhuman primates show quite mature neuronal properties near birth although visual function is itself quite immature and continues to develop over many months or years after birth. Our goal was to assess the relative development of two main visual processing streams, dorsal and ventral, using BOLD fMRI in an attempt to understand the global mechanisms that support the maturation of visual behavior. Seven infant macaque monkeys (Macaca mulatta) were repeatedly scanned, while anesthetized, over an age range of 102 to 1431 days. Large rotating checkerboard stimuli induced BOLD activation in visual cortices at early ages. Additionally we used static and dynamic Glass pattern stimuli to probe BOLD responses in primary visual cortex and two extrastriate areas: V4 and MT-V5. The resulting activations were analyzed with standard GLM and multivoxel pattern analysis (MVPA) approaches. We analyzed three contrasts: Glass pattern present/absent, static/dynamic Glass pattern presentation, and structured/random Glass pattern form. For both GLM and MVPA approaches, robust coherent BOLD activation appeared relatively late in comparison to the maturation of known neuronal properties and the development of behavioral sensitivity to Glass patterns. Robust differential activity to Glass pattern present/absent and dynamic/static stimulus presentation appeared first in V1, followed by V4 and MT-V5 at older ages; there was no reliable distinction between the two extrastriate areas. A similar pattern of results was obtained with the two analysis methods, although MVPA analysis showed reliable differential responses emerging at later ages than GLM. Although BOLD responses to large visual stimuli are detectable, our results with more refined stimuli indicate that global BOLD activity changes as behavioral performance matures. This reflects an hierarchical development of the visual pathways. Since fMRI BOLD reflects neural activity on a population level, our results indicate that, although individual neurons might be adult-like, a longer maturation process takes place on a population level.

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“…Lateral spatial interactions among objects in a visual scene can have either inhibitory or facilitative effects on visual perception. Inhibitory interactions are present at birth, suggesting they are mediated by local inhibitory processing within V1, while facilitative effects develop over the first year, suggesting they are mediated by long‐range feedback connections to V1 (Li et al, ). Similarly, the ability to discriminate textures (El‐Shamayleh et al, ) appears within months of birth.…”

Section: Structure Function and Development Of Marmoset Areas V1 Anmentioning

confidence: 99%

Neural plasticity following lesions of the primate occipital lobe: The marmoset as an animal model for studies of blindsight

Hagan

Rosa

Lui

2016

Developmental Neurobiology

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For nearly a century it has been observed that some residual visually guided behavior can persist after damage to the primary visual cortex (V1) in primates. The age at which damage to V1 occurs leads to different outcomes, with V1 lesions in infancy allowing better preservation of visual faculties in comparison with those incurred in adulthood. While adult V1 lesions may still allow retention of some limited visual abilities, these are subconscious-a characteristic that has led to this form of residual vision being referred to as blindsight. The neural basis of blindsight has been of great interest to the neuroscience community, with particular focus on understanding the contributions of the different subcortical pathways and cortical areas that may underlie this phenomenon. More recently, research has started to address which forms of neural plasticity occur following V1 lesions at different ages, including work using marmoset monkeys. The relatively rapid postnatal development of this species, allied to the lissencephalic brains and well-characterized visual cortex provide significant technical advantages, which allow controlled experiments exploring visual function in the absence of V1. © 2016 Wiley Periodicals, Inc. Develop Neurobiol 77: 314-327, 2017.

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Linking structure and function: Development of lateral spatial interactions in macaque monkeys

Cited by 8 publications

References 62 publications

Pyramidal cell development: postnatal spinogenesis, dendritic growth, axon growth, and electrophysiology

Pyramidal cell development: postnatal spinogenesis, dendritic growth, axon growth, and electrophysiology

Development of visual cortical function in infant macaques: A BOLD fMRI study

Neural plasticity following lesions of the primate occipital lobe: The marmoset as an animal model for studies of blindsight

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