Linking social cognition with social interaction: Non-verbal expressivity, social competence and "mentalising" in patients with schizophrenia spectrum disorders

Brüne, Martin; Abdel‐Hamid, Mona; Sonntag, Claudia; Lehmkämper, Caroline; Langdon, Robyn

doi:10.1186/1744-9081-5-6

Cited by 44 publications

(35 citation statements)

References 41 publications

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“…Gold et al, 2012; Leitman et al, 2005) have also found deficits in the perception of voices, particularly pitch and rhythm. 2) Mentalizing (also known as theory of mind, or mental state attribution) is the ability to infer the mental states of others (Baron-Cohen et al, 2001) and is also known to be impaired in schizophrenia (Brüne et al, 2009; Harrington et al, 2005; Savla et al, 2013). Mentalizing deficits result in misinterpretation of hints, intentions, deception, metaphor, and irony (Penn et al, 2008).…”

Section: Oxytocin Effects On Social Cognitive Deficits In Schizophmentioning

confidence: 99%

Oxytocin effects in schizophrenia: Reconciling mixed findings and moving forward

Bradley

Woolley

2017

Neuroscience & Biobehavioral Reviews

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Schizophrenia is a severe mental illness that causes major functional impairment. Current pharmacologic treatments are inadequate, particularly for addressing negative and cognitive symptoms of the disorder. Oxytocin, a neuropeptide known to moderate social behaviors, has been investigated as a potential therapeutic for schizophrenia in recent years. Results have been decidedly mixed, leading to controversy regarding oxytocin's utility. In this review, we outline several considerations for interpreting the extant literature and propose a focused agenda for future work that builds on the most compelling findings regarding oxytocin effects in schizophrenia to date. Specifically, we examine underlying causes of heterogeneity in randomized clinical trials (RCTs) conducted thus far and highlight the complexity of the human oxytocin system. We then review evidence of oxytocin's effects on specific deficits in schizophrenia, arguing for further study using objective, precise outcome measures in order to determine whether oxytocin has the potential to improve functional impairment in schizophrenia.

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Section: Oxytocin Effects On Social Cognitive Deficits In Schizophmentioning

confidence: 99%

Oxytocin effects in schizophrenia: Reconciling mixed findings and moving forward

Bradley

Woolley

2017

Neuroscience & Biobehavioral Reviews

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“…Whilst this analysis identified a difference between patients with schizophrenia and depression, several ethological studies have shown that patients with schizophrenia can be distinguished from healthy subjects on the basis of their non-verbal communication, particularly by their lack of behaviour encouraging ongoing social interaction during the interview [21] . In an Italian study of young men with a diagnosis of recent-onset schizophrenia, non-verbal behavioural patterns clearly distinguished schizophrenia patients from control subjects, with a global restriction of non-verbal expressiveness in the patient group [22] .…”

Section: Comparison With the Literaturementioning

confidence: 99%

Non-Verbal Behaviour of Patients with Schizophrenia in Medical Consultations – A Comparison with Depressed Patients and Association with Symptom Levels

Dimic

Wildgrube²,

McCabe³

et al. 2010

Psychopathology

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Background: The Dutch psychiatrist Rümke introduced the notion that patients with schizophrenia could be recognised intuitively by an experienced psychiatrist, naming the process as the ‘praecox feeling’. This feeling may reflect aspects of the non-verbal behaviour of patients as shown in a medical consultation. The aim of this study was to test whether aspects of the initial non-verbal behaviour of patients with schizophrenia and depression in medical consultations differ and are associated with symptom levels in each group. Sampling and Method: The first 2 min of videotaped outpatient consultations with 78 patients (39 each with schizophrenia and depression) were analysed by researchers who were masked to the diagnosis and symptom levels of the patients. Non-verbal behaviour was assessed using a modified Ethological Coding System for Interviews. Symptom levels were rated by independent researchers on the Positive and Negative Syndrome Scale and Beck Depression Inventory. Results: The 2 diagnostic groups showed significant differences on 1 out of 6 aspects of non-verbal communication, with patients with schizophrenia exhibiting more ‘flight’ behaviour, i.e. more looking down or away, crouching and freezing. Within the group of patients with schizophrenia, more ‘flight’ and less ‘assertion’ were associated with higher symptom levels. Conclusion: Initial ‘flight’ behaviour of patients in medical consultations may be specific for schizophrenia and associated with the symptoms of that illness. Such behaviour might indicate an avoidance of potentially adverse communication, and future research should investigate whether it can also be identified in everyday social interactions other than medical consultations.

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“…A recent meta-analysis has shown theory of mind deficits in both first-episode and remitted patients, suggesting that these deficits are inherent to the illness [22]. In the past, theory of minds skills were thought to be highly correlated with neurocognitive variables, such as intelligence quotient and verbal memory, although recently some have concluded that deficits in theory of mind may be independent of neurocognitive deficits [23]. It is still not clear as to how or to what extent deficits in theory of mind contribute to dysfunctional social behavior [24], although an impaired ability for mental state attribution has been shown to be the single best predictor of social competency when compared with measures of neurocognitive functioning and psychopathology [25].…”

Section: Social Cognition In Schizophreniamentioning

confidence: 98%

Potential therapeutic avenues to tackle social cognition problems in schizophrenia

Brown

Taş

Brüne

2012

Expert Review of Neurotherapeutics

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Therapeutic strategies for improving social cognition in patients with schizophrenia have shown much promise in improving social functioning, as well as remediating core psychotic symptoms. However, the efficacy of previous interventions has often been limited by the ambiguity and inconsistency of the categorized subdomains of social cognition, including theory of mind, emotion processing, social perception and attributional bias. Recent research in social and cognitive neuroscience has revealed many new issues that could contribute to the development of more integrated approaches for improving social functioning. The application of such neuroscientific work to a therapeutic and diagnostic context is likely to encourage more effective transference of learned skills to real-world social functioning. This article seeks to provide a comprehensive review of previous social cognitive interventions for schizophrenia, highlight some crucial limitations of these and present the relevance of recent advances in neuroscientific research in possible future treatment strategies. It is emphasized that a more integrated and naturalistic approach for improving social functioning with greater sensitivity for neuroscientific findings related to the psychopathology of schizophrenia is warranted.

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Linking social cognition with social interaction: Non-verbal expressivity, social competence and "mentalising" in patients with schizophrenia spectrum disorders

Cited by 44 publications

References 41 publications

Oxytocin effects in schizophrenia: Reconciling mixed findings and moving forward

Oxytocin effects in schizophrenia: Reconciling mixed findings and moving forward

Non-Verbal Behaviour of Patients with Schizophrenia in Medical Consultations – A Comparison with Depressed Patients and Association with Symptom Levels

Potential therapeutic avenues to tackle social cognition problems in schizophrenia

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