Linking Sepsis with chronic arterial hypertension, diabetes mellitus, and socioeconomic factors in the United States: A scoping review

Ahlberg, Caitlyn D.; Wallam, Sara; Tirba, Lemya A.; Itumba, Stephanie N.; Gorman, Linda; Galiatsatos, Panagis

doi:10.1016/j.jcrc.2023.154324

Cited by 4 publications

(2 citation statements)

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“…Although infection (including bacteria, fungi, viruses, etc.) is the direct cause of sepsis, many factors such as diabetes, hypertension, neurological disorders, obesity, etc., also contribute to an increased risk of sepsis (5)(6)(7). Due to the rapid onset and progression of sepsis, primary prevention targeting the risk factors for sepsis becomes even more important.…”

Section: Introductionmentioning

confidence: 99%

Exploring the relationship between life course adiposity and sepsis: insights from a two-sample Mendelian randomization analysis

Cheng,

Li,

Tong

et al. 2024

Front. Endocrinol.

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ObjectivesThe relationship between adiposity and sepsis has received increasing attention. This study aims to explore the causal relationship between life course adiposity and the sepsis incidence.MethodsMendelian randomization (MR) method was employed in this study. Instrumental variants were obtained from genome-wide association studies for life course adiposity, including birth weight, childhood body mass index (BMI), childhood obesity, adult BMI, waist circumference, visceral adiposity, and body fat percentage. A meta-analysis of genome-wide association studies for sepsis including 10,154 cases and 454,764 controls was used in this study. MR analyses were performed using inverse variance weighted, MR Egger regression, weighted median, weighted mode, and simple mode. Instrumental variables were identified as significant single nucleotide polymorphisms at the genome-wide significance level (P < 5×10-8). The sensitivity analysis was conducted to assess the reliability of the MR estimates.ResultsAnalysis using the MR analysis of inverse variance weighted method revealed that genetic predisposition to increased childhood BMI (OR = 1.29, P = 0.003), childhood obesity (OR = 1.07, P = 0.034), adult BMI (OR = 1.38, P < 0.001), adult waist circumference (OR = 1.01, P = 0.028), and adult visceral adiposity (OR = 1.53, P < 0.001) predicted a higher risk of sepsis. Sensitivity analysis did not identify any bias in the MR results.ConclusionThe results demonstrated that adiposity in childhood and adults had causal effects on sepsis incidence. However, more well-designed studies are still needed to validate their association.

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Section: Introductionmentioning

confidence: 99%