Linking RDoC and HiTOP: A new interface for advancing psychiatric nosology and neuroscience

Michelini, Giorgia; Palumbo, Isabella M.; DeYoung, Colin G.; Latzman, Robert D.; Kotov, Roman

doi:10.1016/j.cpr.2021.102025

Cited by 129 publications

(105 citation statements)

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“…HiTOP and RDoC have specific similarities and differences in strategy and approach to psychopathology research, as described in more detail elsewhere (Michelini, Palumbo, DeYoung, Latzman, & Kotov, 2021) and below. An important point from our perspective, though, is that these major efforts stand in stark contrast to the idea of organizing research by traditional psychiatric categories but are well aligned with a long tradition of dimensional models in personality research.…”

Section: Dimensional Modelsmentioning

confidence: 99%

“…neuroscience research efforts (Michelini et al, 2021). Specifically, Michelini and colleagues (2021) sought to map an interface (or "cross-walk") between HiTOP and RDoC based on review of studies that investigated associations between constructs consistent with these frameworks.…”

Section: Linking Integrated Models Of Personalitypsychopathology To Research Initiativesmentioning

confidence: 99%

“…Considering the well-established parallels between normal personality and dimensions of psychopathology included in HiTOP, as well as between RDoC constructs and constructs included in ANA and NIDA PhAB, it may be possible to draw an integrative research landscape linking personality, psychopathology, and biobehavioral dimensions. We represent this landscape in Figure 1, which builds on the major connections between HiTOP and RDoC identified by Michelini et al (2021) by showing conceptual links to normal personality (on the left side) and ANA and NIDA PhAB frameworks (on the right side). Ultimately, integrative research efforts focused on personality, psychopathology, and their neural/etiological bases have the potential to promote parallel progress in understanding the underpinnings of behavioral and clinical phenomena and in informing clinical practice with regard to assessment and treatment.…”

Section: Linking Integrated Models Of Personalitypsychopathology To Research Initiativesmentioning

confidence: 99%

“…Within a clinical population, the ranges of personality/symptom dimensions and of neural functioning are likely to be restricted, making it harder to identify the dimensions of variation that are most important for psychopathology. An alternative approach is to characterize large diverse samples using dimensional constructs consistent with HiTOP and integrated personality-psychopathology approaches Michelini et al, 2021). This approach, using broad HiTOPconformant assessments that inherently account for the multidimensional nature of psychopathology, adopted by several studies in this special issue (Hyatt et al, 2020;Neumann, 2020;Palumbo et al, 2020;Weiss et al, 2021), allows researchers to simultaneously characterize the underpinnings of latent dimensions that span the "normal" personality range (e.g., low to high disinhibition) and the clinical manifestations that lie on the same continuum (e.g., substance abuse and antisocial behavior).…”

Section: Recommendations For Advancing the Neuroscience Of Personality-psychopathologymentioning

confidence: 99%

“…This has also had the unfortunate consequence that many clinical case-control studies, besides studying flawed diagnostic constructs, were grossly underpowered, resulting in inflated effects. Recently, however, the need for much larger samples has been recognized in clinical neuroscience (Marek et al, 2020;Michelini et al, 2021), which will facilitate integrating personality and clinical neuroscience. Considering articles in this special issue, whereas a few studies used small samples of less than 100 subjects, the majority of the empirical studies included several hundreds of participants, suggesting a positive trend toward more reproducible effects.…”

Section: Recommendations For Advancing the Neuroscience Of Personality-psychopathologymentioning

confidence: 99%

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Connecting quantitatively derived personality–psychopathology models and neuroscience

Latzman

Krueger

DeYoung

et al. 2021

Personality Neuroscience

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Traditionally, personality has been conceptualized in terms of dimensions of human experience – habitual ways of thinking, feeling, and behaving. By contrast, psychopathology has traditionally been conceptualized in terms of categories of disorder – disordered thinking, feeling, and behaving. The empirical literature, however, routinely shows that psychopathology does not coalesce into readily distinguishable categories. Indeed, psychopathology tends to delineate dimensions that are relatively similar to dimensions of personality. In this special issue of Personality Neuroscience, authors took up the challenge of reconceptualizing personality and psychopathology in terms of connected and interrelated dimensions, and they considered the utility of pursuing neuroscientific inquiry from this more integrative perspective. In this editorial article, we provide the relevant background to the interface between personality, psychopathology, and neuroscience; summarize contributions to the special issue; and point toward directions for continued research and refinement. All told, it is evident that quantitatively derived, integrative models of personality–psychopathology represent a particularly promising conduit for advancing our understanding of the neurobiological foundation of human experience, both functional and dysfunctional.

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Section: Dimensional Modelsmentioning

confidence: 99%

Section: Linking Integrated Models Of Personalitypsychopathology To Research Initiativesmentioning

confidence: 99%

Section: Linking Integrated Models Of Personalitypsychopathology To Research Initiativesmentioning

confidence: 99%

Section: Recommendations For Advancing the Neuroscience Of Personality-psychopathologymentioning

confidence: 99%

Section: Recommendations For Advancing the Neuroscience Of Personality-psychopathologymentioning

confidence: 99%

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Connecting quantitatively derived personality–psychopathology models and neuroscience

Latzman

Krueger

DeYoung

et al. 2021

Personality Neuroscience

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Being Precise About Precision Mental Health

Szatmári

Susser

2022

JAMA Psychiatry

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Autonomic dysregulation and self‐injurious thoughts and behaviours in children and young people: A systematic review and meta‐analysis

et al. 2023

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BackgroundSelf‐injurious thoughts and behaviours (SITBs) have been associated with dysfunction of the Autonomic Nervous System (ANS) in children and young people, suggesting that objective ANS measures may aid assessment of suicide risk, but a systematic synthesis of this literature is currently lacking.MethodsFollowing a pre‐registered protocol (PROSPERO CRD42022327605), we conducted a systematic search of PubMed, Medline, Embase, PsycINFO, and Web of Science, for empirical studies published until 10th May 2022 that compared indices of ANS functioning in individuals aged 0–25 years with versus without SITBs, or reported continuous associations between ANS measures and SITBs. Study quality was assessed with the Newcastle‐Ottawa Scales. Pooled effect sizes (Hedge's g) were estimated with random‐effects meta‐analytic models.ResultsTwenty studies (1979 participants) were included in our systematic review, with 16 included in meta‐analyses. Results suggested that SITBs were associated with altered cardiac indices of arousal (g = −0.328, p < 0.001), which was driven by lower heart rate variability in individuals with SITBs (g = −0.375, p = 0.025). Overall results for electrodermal activity were not significant (g = 0.026, p = 0.857), but subgroup analyses showed increased activity in studies of individuals who engaged specifically in non‐suicidal self‐harm (g = 0.249, p = 0.014) but decreased activity in the remaining studies (g = −0.567, p = 0.004).ConclusionsOur systematic review and meta‐analysis found evidence of reduced parasympathetic regulation as well as more tentative evidence of altered electrodermal activity in children and young people displaying SITBs. Future longitudinal studies should test the clinical utility of these markers for detecting and monitoring suicide risk.

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Linking RDoC and HiTOP: A new interface for advancing psychiatric nosology and neuroscience

Cited by 129 publications

References 348 publications

Connecting quantitatively derived personality–psychopathology models and neuroscience

Connecting quantitatively derived personality–psychopathology models and neuroscience

Being Precise About Precision Mental Health

Autonomic dysregulation and self‐injurious thoughts and behaviours in children and young people: A systematic review and meta‐analysis

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