Linking nutrient stoichiometry to Zika virus transmission in a mosquito

Paige, Andrew S.; Bellamy, Shawna K.; Alto, Barry W.; Dean, Catherine L.; Yee, Donald

doi:10.1007/s00442-019-04429-6

Cited by 9 publications

(5 citation statements)

References 52 publications

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“…One reason is that nutrients can also affect the ability of adult mosquitoes to transmit pathogens of medical importance. Specifically, Paige et al (2019) found that high nitrogen environments promoted lower disseminated infection and transmission of Zika virus in female Ae.…”

Section: Discussionmentioning

confidence: 99%

Competitive interactions with Aedes albopictus alter the nutrient content of Aedes aegypti

Deerman

Yee

2023

Medical Vet Entomology

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Competition is often cited as a central force that affects the distribution and performance of organisms. Ecological stoichiometry is the balance of elements within animal bodies that can be affected by resource acquisition and processing, as well as by intra‐ or interspecific interactions. Though relatively underexplored for mosquitoes, stoichiometry may provide a wealth of information linking ecological interactions to body nutrient content, and potentially on to pathogen transmission. Detritus, which often varies in nutrient content, forms the base of the food web within the small aquatic habitats occupied by larval mosquitoes, and detrital nutrient content can alter mosquito growth, survival, and population growth. The invasive mosquitoes Aedes albopictus (Diptera: Culicidae) and Aedes aegypti (Diptera: Culicidae) interact as larvae in aquatic systems, often altering their adult populations. Herein, we investigated how different detritus combinations as well as how intra‐ and interspecific densities of Ae. albopictus and Ae. aegypti would affect coexistence; we also measured how nutrient composition (carbon and nitrogen) and stoichiometry (C:N) of adults would vary with those interactions. Ae. albopictus survival, population growth, and stoichiometry were not affected by intra‐ or interspecific competition; nutrient values did vary with detritus ratios. However, Ae. aegypti nutrient content and stoichiometry and survival were negatively affected within the lowest nutrient environments in the presence of Ae. albopictus, but in the highest nutrient environments, both species showed high survival rates and population growth. This is the first study to show that adult mosquito body nutrients can be altered by interspecific interactions, and as nutrient content in adults has been linked to pathogen transmission, it provides a novel role of competition in affecting disease dynamics.

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Section: Discussionmentioning

confidence: 99%

Competitive interactions with Aedes albopictus alter the nutrient content of Aedes aegypti

Deerman

Yee

2023

Medical Vet Entomology

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“…For instance, mosquito larval hosts of Zika virus exhibit accelerated growth and earlier maturation when provided with an N-rich diet featuring high N:P ratios. This results in a shorter transmission period and reduced risk of infection in humans [ 77 ].…”

Section: Impact Of Nutrient Imbalances On Human Healthmentioning

confidence: 99%

Human-driven global nutrient imbalances increase risks to health

Penuelas,

Sardans

2023

Eco-Environment & Health

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“…Larval diet quality impacts rates of Zika-virus infection and transmission in adult mosquitoes. Murrell et al, 2011;Paige et al, 2019 Environmental toxins Se:Hg ratios impact the transfer of Hg through aquatic food webs (including to human food sources) and the effects of Hg within the human body. High environmental As:P ratios disrupt ATP formation.…”

Section: Topic Finding Referencesmentioning

confidence: 99%

“…Evidence from several disease systems indicates that shifts in the stoichiometry of the environment can cascade to alter the elemental composition or other aspects of host and vector physiology, thus altering the resources available to parasites and mediating transmission risk (Sanders and Taylor, 2018). For example, mosquitoes that consumed high quality diets as larvae matured into adults that were higher in %N, which corresponded to lower rates of Zika virus infection and transmission potential (Paige et al, 2019). While the mechanism behind this shift is unknown, it may reflect elemental requirements of mosquito immune function.…”

Section: Environmental Stoichiometry Mediates Human Infection Riskmentioning

confidence: 99%

Elemental Ratios Link Environmental Change and Human Health

et al. 2019

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Humans have fundamentally altered the cycling of multiple elements on a global scale. These changes impact the structure and function of terrestrial and aquatic ecosystems, with many implications for human health. Most prior studies linking biogeochemical changes to human health have evaluated the effects of single elements in isolation. However, the relative availability of multiple elements often determines the biological impact of shifts in the concentration of a single element. The balance of multiple elements is the focus of ecological stoichiometry, which highlights the importance of elemental ratios in biological function across all systems and scales of organization. Consequently, ecological stoichiometry is a promising framework to inform research on the links between global changes to elemental cycles and human health. We synthesize evidence that elemental ratios link global change with human health through biological processes occurring at two scales: in the environment (natural ecosystems and food systems) and within the human body. Elemental ratios in the environment impact the key ecosystem processes of productivity and biodiversity, both of which contribute to the production of food, toxins, allergens, and parasites. Elemental ratios in diet impact processes within the human body, including the function and interactions of the immune system, parasites, and the non-pathogenic microbiome. Collectively, these stoichiometric effects contribute to a wide range of non-infectious and infectious diseases. By describing stoichiometric mechanisms linking global change, ecological processes, and human health, we hope to inspire future empirical and theoretical research on this theme.

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Linking nutrient stoichiometry to Zika virus transmission in a mosquito

Abstract: DAY and BWA conceived of and designed the project. ASP and SKB carried out mosquito husbandry, viral propagation, molecular work and collected project data. CLD performed the nutrient analyses and mosquito wing length measurements. DAY analyzed and interpreted the data with BWA.

Cited by 9 publications

References 52 publications

Competitive interactions with Aedes albopictus alter the nutrient content of Aedes aegypti

Competitive interactions with Aedes albopictus alter the nutrient content of Aedes aegypti

Human-driven global nutrient imbalances increase risks to health

Elemental Ratios Link Environmental Change and Human Health

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