Linking neuroscience with modern concepts of impulse control disorders in Parkinson's disease

Napier, T. Celeste; Corvol, Jean‐Christophe; Grace, Anthony A.; Roitman, Jamie D.; Rowe, James B.; Voon, Valerie; Strafella, Antonio P.

doi:10.1002/mds.26068

Cited by 85 publications

(67 citation statements)

References 91 publications

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“…Spontaneous firing rates ranged from 1.5 to 8.0 Hz (4.6 Ϯ 0.3 Hz) and the firing pattern was categorized as pacemaker (17.4%, 4/23), irregular (26.1%, 6/23), or bursting (56.5%, 13/23). As reported previously (Ji and Shepard, 2007), single-pulse stimulation of the LHb inhibited the majority of DA cells recorded (93.3%, 28/30; Fig. 1C).…”

Section: Resultssupporting

confidence: 89%

“…Cell loss in the MRn was limited to the rostral portion and was smaller in magnitude than neuronal loss within the RMTg. The PPTg, an important source of excitatory input to the ventral midbrain (Lokwan et al, 1999;Floresco et al, 2003), was not affected significantly. The degree of cell loss was quantified only within the rostral portions of the MRn and the PPTg that overlapped with the RMTg, accounting for ϳ25% of the total MRn and 40% of the total PPTg rostral-caudal extent.…”

Section: Qa Lesions Of the Rmtg: Selectivity And Effect Sizementioning

confidence: 94%

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Habenula-Induced Inhibition of Midbrain Dopamine Neurons Is Diminished by Lesions of the Rostromedial Tegmental Nucleus

Brown¹,

Palacorolla²,

Brady³

et al. 2017

J. Neurosci.

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Section: Resultssupporting

confidence: 89%

Section: Qa Lesions Of the Rmtg: Selectivity And Effect Sizementioning

confidence: 94%

Habenula-Induced Inhibition of Midbrain Dopamine Neurons Is Diminished by Lesions of the Rostromedial Tegmental Nucleus

Brown¹,

Palacorolla²,

Brady³

et al. 2017

J. Neurosci.

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“…Fig. 1 from Napier et al [32] provides an overview of the neural interactions between ventral striatum and other key structures during the reward processing. This model suggests that when a task is rewarding, there is an increase in dopamine input, facilitating the hippocampal drive (D1 dependent process) to maintain focus on the current rewarded task while preventing the prefrontal cortex (D2 dependent process) from deviating from this task (left diagram).…”

Section: Discussionmentioning

confidence: 99%

Molecular imaging and neural networks in impulse control disorders in Parkinson's disease

Aracil‐Bolaños

Strafella

2016

Parkinsonism & Related Disorders

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Impulse control disorders (ICDs) may arise in Parkinson's disease (PD) in relation to the use of dopamine agonists (DA). A dysfunction of reward circuits is considered the main underlying mechanism. Neuroimaging has been largely used in this setting to understand the structure of the reward system and its abnormalities brought by exogenous stimulation in PD. Dopaminergic changes, such as increased dopamine release, reduced dopamine transporter activity and other changes, have been shown to be a consistent feature of ICDs in PD. Beyond the striatum, alterations of prefrontal cortical function may also impact an individuals' propensity for impulsivity. Neuroimaging is advancing our knowledge of the mechanisms involved in the development of these behavioral addictions. An increased understanding of these disorders may lead to the discovery of new therapeutic targets, or the identification of risk factors for the development of these disorders.

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“…7 It is more common in men than in women. A U.S. survey found the lifetime prevalence in men to be 0.64% versus 0.23% in women.…”

Section: Prevalencementioning

confidence: 99%

Untitled

2018

MOJAMT

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Abbreviations: PET, positron emission tomography; COMT, cathechol-o-methyl transferase; MAO, monoamine oxidase; CBT, cognitive behaviour therapy; PD, parkinson's disease; GD, gambling disorder IntroductionImpulse control disorders such as compulsive gambling or compulsive shopping or uncontrollable sexual and eating behaviour, are well-recognized complications of Parkinson's disease (PD). They occur in up to 20% of PD patients.1 These disorders impair quality of life and function, place incalculable burdens on interpersonal relationships and on caregivers, and are associated with significant psychiatric co-morbidity.2 The Diagnostic and Statistical Manual of Mental Disorders, 5 th edition (DSM-V) 3 has classified Gambling Disorder (GD), previously viewed as an impulse control disorder, as a behavioural addiction. To qualify for this diagnosis, patients must meet at least four of the following nine criteria in the course of one year: a. Gambling increasing amounts of money in order to keep obtaining the same level of excitement.b. Experiencing restlessness or irritability when trying to stop gambling.c. Trying repeatedly and unsuccessfully to stop.d. Being constantly preoccupied with gambling.e. Gambling when distressed.f. Continually returning to gambling in order to make up for monetary losses.g. Covering up the extent of one's involvement in gambling.h. Jeopardizing relationships and careers because of gambling.i. Borrowing money from others to cover gambling debts.Gambling can be viewed as an impulse disorder or as an addiction. There are many forms of gambling, including card games, electronic games, betting on results of athletic or political contests. The most frequent forms of gambling in North America are reportedly playing the slot machines, buying lottery scratch cards and playing bingo. Having a gambling addiction means preferentially selecting immediate, albeit risky, opportunities to make money instead of relying on a longer-range strategy that is both safer and more lucrative. A small amount of immediate gain takes precedence for the pathological gambler over a larger gain that requires a period of waiting. Decisions made by pathological gamblers appear to be rash, with little thought of probable consequences such as financial burden, interference with career, or dissolution of family bonds. Immediate satisfaction is valued over potential risks. Even repeated negative consequences do not seem to act as deterrents. Individuals with PD who suffer from GD exhibit uncontrollable cravings, develop tolerance, and experience withdrawal symptoms in the same way as those who suffer from drug or alcohol addiction, and there is a high degree of co-morbidity between these conditions. 5,6 AimThe aim of this brief overview is to determine whether GD can help to shed light on the etiology of Parkinson's disease, and whether aspects of Parkinson's disease, including its treatment, can help to clarify the basis of GD. MethodThere is a substantial literature on GD in Parkinson's. Via the PubMed database, articles fr...

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Linking neuroscience with modern concepts of impulse control disorders in Parkinson's disease

Cited by 85 publications

References 91 publications

Habenula-Induced Inhibition of Midbrain Dopamine Neurons Is Diminished by Lesions of the Rostromedial Tegmental Nucleus

Habenula-Induced Inhibition of Midbrain Dopamine Neurons Is Diminished by Lesions of the Rostromedial Tegmental Nucleus

Molecular imaging and neural networks in impulse control disorders in Parkinson's disease

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