2019
DOI: 10.1002/etc.4453
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Linking Mitochondrial Dysfunction to Organismal and Population Health in the Context of Environmental Pollutants: Progress and Considerations for Mitochondrial Adverse Outcome Pathways

Abstract: Mitochondria are key targets of many environmental contaminants, because specific chemicals can interact directly with mitochondrial proteins, lipids, and ribonucleic acids. These direct interactions serve as molecular initiating events that impede adenosine triphosphate production and other critical functions that mitochondria serve within the cell (e.g., calcium and metal homeostasis, apoptosis, immune signaling, redox balance). A limited but growing number of adverse outcome pathways (AOPs) have been propos… Show more

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Cited by 36 publications
(25 citation statements)
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“…There is accumulating evidence that chemical-induced organ toxicity involves disruption of mitochondrial function more frequently than previously considered (Dykens and Will 2007 ; Will et al 2019 ; Dreier et al 2019 ). Mitochondrial perturbations can have major effects on tissues and organs due to their key role in fatty acid metabolism, energy production and generation of reactive oxygen species (ROS).…”
Section: Introductionmentioning
confidence: 99%
“…There is accumulating evidence that chemical-induced organ toxicity involves disruption of mitochondrial function more frequently than previously considered (Dykens and Will 2007 ; Will et al 2019 ; Dreier et al 2019 ). Mitochondrial perturbations can have major effects on tissues and organs due to their key role in fatty acid metabolism, energy production and generation of reactive oxygen species (ROS).…”
Section: Introductionmentioning
confidence: 99%
“…However, this effort should include a detailed weight-of-evidence analysis, which is beyond the scope of the current analysis but should be part of future work. Drier et al has summarized key events and other AOPs associated with mitochondrial toxicity (Dreier et al, 2019).…”
Section: Discussionmentioning
confidence: 99%
“…2015 ; Javadov et al. 2020 ) and modeled in the mouse ( Wallace and Fan 2009 ) led to consideration of mitochondrial dysfunction as a key characteristic of toxicity and prompted the formulation of mitochondrial-based adverse outcome pathways ( Dreier et al. 2019 ; Goodchild et al.…”
Section: Introductionmentioning
confidence: 99%