Linking Function and Structure with ReSensNet

Seeböck, Philipp; Vogl, Wolf‐Dieter; Waldstein, Sebastian M.; Orlando, José Ignacio; Baratsits, Magdalena; Alten, Thomas; Arikan, Mustafa; Mylonas, Georgios; Bogunović, Hrvoje; Schmidt‐Erfurth, Ursula

doi:10.1016/j.oret.2022.01.021

Cited by 14 publications

(7 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most of these efforts have targeted prediction of VA from OCT images 35 , 36 . Specific to microperimetry, Seebock et al developed a deep learning model (ReSensNet) for the prediction of retinal sensitivities from OCT images with AMD 37 . In their study, specific AMD lesions were not delineated for corresponding RS prediction.…”

Section: Discussionmentioning

confidence: 99%

Defining the structure–function relationship of specific lesions in early and advanced age-related macular degeneration

Tan,

Yap,

Peterson

et al. 2024

Sci Rep

View full text Add to dashboard Cite

The objective of this study is to define structure–function relationships of pathological lesions related to age-related macular degeneration (AMD) using microperimetry and multimodal retinal imaging. We conducted a cross-sectional study of 87 patients with AMD (30 eyes with early and intermediate AMD and 110 eyes with advanced AMD), compared to 33 normal controls (66 eyes) recruited from a single tertiary center. All participants had enface and cross-sectional optical coherence tomography (Heidelberg HRA-2), OCT angiography, color and infra-red (IR) fundus and microperimetry (MP) (Nidek MP-3) performed. Multimodal images were graded for specific AMD pathological lesions. A custom marking tool was used to demarcate lesion boundaries on corresponding enface IR images, and subsequently superimposed onto MP color fundus photographs with retinal sensitivity points (RSP). The resulting overlay was used to correlate pathological structural changes to zonal functional changes. Mean age of patients with early/intermediate AMD, advanced AMD and controls were 73(SD = 8.2), 70.8(SD = 8), and 65.4(SD = 7.7) years respectively. Mean retinal sensitivity (MRS) of both early/intermediate (23.1 dB; SD = 5.5) and advanced AMD (18.1 dB; SD = 7.8) eyes were significantly worse than controls (27.8 dB, SD = 4.3) (p < 0.01). Advanced AMD eyes had significantly more unstable fixation (70%; SD = 63.6), larger mean fixation area (3.9 mm2; SD = 3.0), and focal fixation point further away from the fovea (0.7 mm; SD = 0.8), than controls (29%; SD = 43.9; 2.6 mm2; SD = 1.9; 0.4 mm; SD = 0.3) (p ≤ 0.01). Notably, 22 fellow eyes of AMD eyes (25.7 dB; SD = 3.0), with no AMD lesions, still had lower MRS than controls (p = 0.04). For specific AMD-related lesions, end-stage changes such as fibrosis (5.5 dB, SD = 5.4 dB) and atrophy (6.2 dB, SD = 7.0 dB) had the lowest MRS; while drusen and pigment epithelial detachment (17.7 dB, SD = 8.0 dB) had the highest MRS. Peri-lesional areas (20.2 dB, SD = 7.6 dB) and surrounding structurally normal areas (22.2 dB, SD = 6.9 dB) of the retina with no AMD lesions still had lower MRS compared to controls (27.8 dB, SD = 4.3 dB) (p < 0.01). Our detailed topographic structure–function correlation identified specific AMD pathological changes associated with a poorer visual function. This can provide an added value to the assessment of visual function to optimize treatment outcomes to existing and potentially future novel therapies.

show abstract

Section: Discussionmentioning

confidence: 99%

Defining the structure–function relationship of specific lesions in early and advanced age-related macular degeneration

Tan,

Yap,

Peterson

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Macular sensitivity is associated with retinal structure and can help to predict BCVA after anti-VEGF treatment [21]. Research is also examining the use of deep learning for predicting macular sensitivity and retinal function from structural OCT scans [22]. The aim is to assess visual function indirectly by analyzing structural-imaging findings and to develop feasible methods for use in clinical settings.…”

Section: Discussionmentioning

confidence: 99%

Macular Sensitivity after Intravitreal Ranibizumab Injection for Macular Edema in Central Retinal Vein Occlusion: One versus Three Initial Monthly Injections

Niidome

Noma

Yasuda

et al. 2022

JVD

View full text Add to dashboard Cite

Background: We aimed to compare the macular sensitivity after one initial intravitreal injection of an anti-vascular endothelial growth factor (VEGF) agent followed by pro re nata (PRN) dosing with that after three initial monthly injections followed by PRN dosing in patients with central retinal vein occlusion (CRVO) and macular edema. Methods: We included 20 eyes of 20 patients with treatment-naïve macular edema in CRVO and followed them for 12 months after intravitreal ranibizumab injection (IRI). Before and 1, 3, 6, and 12 months after IRI, macular sensitivity within the central 1 mm, 3 mm, and 6 mm fields was measured with an MP3 microperimeter and best-corrected visual acuity (BCVA) was assessed. Eleven eyes received one initial IRI (1 + PRN group), and nine received three initial monthly IRIs (3 + PRN group). PRN injections were performed when fovea exudative changes were evident. Results: Mean macular sensitivity within the central 1 mm, 3 mm, and 6 mm fields significantly improved from baseline to month 12 in all treated eyes. We found no significant differences in macular sensitivity in the central 1 mm, 3 mm, or 6 mm fields between the two groups at month 1, 3, 6, or 12. The choice of treatment regimen (1 + PRN or 3 + PRN) showed no association with either macular sensitivity in the central 1 mm, 3 mm, and 6 mm fields or BCVA at month 12. Conclusions: These findings suggest that a 1 + PRN regimen improves macular sensitivity to a similar extent as a 3 + PRN regimen.

show abstract

“…The MAE for point-wise sensitivity was 2.73 decibels (dB), and the MAE for mean sensitivity was 1.66 dB. 22…”

Section: Age-related Macular Degenerationmentioning

confidence: 96%

“…19 Using images from healthy individuals and patients with nAMD and GA for training, Seebock et al trained a DL model (ReSensNet) to directly predict retinal sensitivity on MP from OCT images. 22 The model was then tested on an external dataset, consisting of eyes with DMO, retinal vein occlusion and epiretinal membrane. The MAE for point-wise sensitivity was 2.73 decibels (dB), and the MAE for mean sensitivity was 1.66 dB.…”

Section: Age-related Macular Degenerationmentioning

confidence: 99%

Predictive Deep Learning Applications in Ophthalmology

Koseoglu,

Liu

2023

touchREVIEWS in Ophthalmology

View full text Add to dashboard Cite

Therapies for retinal diseases have witnessed remarkable progress, particularly in the domain of drug delivery routes. Intravitreal injections have especially revolutionized the treatment landscape for various proliferative retinopathies. The emergence of suprachoroidal space as a novel drug delivery site is poised to overcome challenges seen in optimizing drug penetration, targeting, and bioavailability. This approach holds promise for delivering various agents, including steroids, anti-vascular endothelial growth factor molecules, gene vectors, and small molecules, with multiple clinical trials demonstrating this delivery method's potential to reduce treatment burdens and optimize visual outcomes. Particularly, small molecule therapy for retinal diseases finds ease of application through the suprachoroidal route in that small molecule agents have a wide range of targets in disease pathway, greater tissue penetration, and cost-effectiveness in production. The suprachoroidal administration of axitinib, a tyrosine kinase inhibitor, has shown promise in the OASIS trial for treating neovascular age-related macular degeneration. Integrin antagonists and plasma Kallikrein-kinin system inhibitors, also delivered suprachoroidally, exhibit targeted distribution and potential for long-acting therapy.

show abstract

Linking Function and Structure with ReSensNet

Cited by 14 publications

References 38 publications

Defining the structure–function relationship of specific lesions in early and advanced age-related macular degeneration

Defining the structure–function relationship of specific lesions in early and advanced age-related macular degeneration

Macular Sensitivity after Intravitreal Ranibizumab Injection for Macular Edema in Central Retinal Vein Occlusion: One versus Three Initial Monthly Injections

Predictive Deep Learning Applications in Ophthalmology

Contact Info

Product

Resources

About