Linking fat intake, the intestinal microbiome, and necrotizing enterocolitis in premature infants

Robinson, Daniel T.; Caplan, Michael S.

doi:10.1038/pr.2014.155

Cited by 14 publications

(8 citation statements)

References 59 publications

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“…High fat maternal diet significantly affects fat and energy content in human milk, which may in turn affect proliferation of bacteria in in the infant gut. 102,103 Human milk contains a relatively high abundance of undigestable oligosaccharides (human milk oligosaccharides, HMOs) that favor proliferation of specific bacteria in the infant gut such as Bifidobacterium spp. 104 The HMO profile of breast milk varies substantially among women, but the effect of maternal diet on HMO composition has not been well characterized.…”

Section: Impact Of Maternal Nutrition During Breastfeedingmentioning

confidence: 99%

Impact of maternal nutrition in pregnancy and lactation on offspring gut microbial composition and function

et al. 2016

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Evidence supporting the Developmental Origins of Health and Disease Hypothesis indicates that maternal nutrition in pregnancy has a significant impact on offspring disease risk later in life, likely by modulating developmental processes in utero. Gut microbiota have recently been explored as a potential mediating factor, as dietary components strongly influence microbiota abundance, function and its impact on host physiology. A growing body of evidence has additionally indicated that the intrauterine environment is not sterile as once presumed, indicating that maternal-fetal transmission of microbiota may occur during pregnancy. In this article, we will review the body of literature that supports this emerging hypothesis, as well as highlight the work in relevant animal models demonstrating associations with maternal gestational nutrition and the offspring gut microbiome that may influence offspring physiology and susceptibility to disease.

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Section: Impact Of Maternal Nutrition During Breastfeedingmentioning

confidence: 99%

Impact of maternal nutrition in pregnancy and lactation on offspring gut microbial composition and function

et al. 2016

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“…In addition, compared with group A, body weight recovery time was shorter and the incidence of EUGR was significantly lower in groups B and C (P<0.05). This result may be due to the fact that probiotics can, not only improve gastrointestinal function, but also synthesize a variety of important vitamins, folic acid, and other nutrients for the body to synthesize amino acids, maintain intestinal pH, and reduce the incidence of neonatal NEC (16). …”

Section: Discussionmentioning

confidence: 99%

Mosapride combined with probiotics on gastrointestinal function and growth in premature infants

Zhang

Sun

Zhang

2017

Experimental and Therapeutic Medicine

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The aim of this study was to investigate the effects of mosapride combined with probiotics on gastrointestinal function and growth and development in premature infants. A total of 240 premature infants treated at Weifang People's Hospital between June 2012 and May 2015 who matched our criteria were randomly divided into three groups of 80 cases each. Group A received routine treatment, group B received routine treatment combined with live B. subtilis and E. faecium granules with multivitamins (Medilac-Vita), and group C received routine treatment and Saccharomyces boulardii sachets (Bioflor). Mosapride was administered to patients in groups B and C to promote intestinal peristalsis. Gastrin and bilirubin levels, as well as jaundice fade time, were recorded. Growth and development condition (i.e., head circumference and weight), duration and incidence of feeding intolerance (FI), as well as other symptoms were also analyzed. By day 14, gastrin concentrations in groups B and C were significantly higher than those in group A (P<0.05). Serum bilirubin levels in groups B and C showed a progressive decline from day 7 to day 14, and jaundice duration in group A was significantly longer (P<0.05). Furthermore, at 2 weeks, the average weight growth rate and head circumference were significantly greater in groups B and C, weight loss recovery time was shorter, and EUGR incidence was lower (P<0.05). The incidence rate of gastric retention and FI were lower in groups B and C than group A (P<0.05), and neonatal hyperbilirubinemia, parenteral nutrition-associated cholestasis, necrotizing enterocolitis, and neonatal sepsis incidence was significantly lower in groups B and C (P<0.05). Mosapride combined with probiotics can effectively reduce FI incidence in premature infants, shorten enteral feeding time, promote the absorption of required nutrients, and promote the development and recovery of early physiological weight loss in preterm infants.

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“…A recent study in Denmark and the United States similarly shows national differences in milk fat content. 43 These geographic variations in breast milk fat profiles are attributed to differences in diet and may affect colonization events in breastfed infants. In support of this notion, in nonhuman primates, it was shown that maternal high-fat diet (36% fat from animal fat and corn oil) consumed during gestation and lactation alters the composition of their offspring's microbiome for up to 1 y, irrespective of the infants' post-weaning diet.…”

Section: Global Dietary Habits Alter Breast Milk Lipid Profile With Lmentioning

confidence: 99%

Human behavior, not race or geography, is the strongest predictor of microbial succession in the gut bacteriome of infants

Quin

Gibson

2020

Gut Microbes

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Colonization of the gastrointestinal tract with microorganisms during infancy represents a critical control point for shaping lifelong immune-mediated disease susceptibility. Abnormal colonization or an imbalance of microbes, termed dysbiosis, is implicated in several diseases. Consequently, recent research has aimed at understanding ways to manipulate a dysbiotic microbiome during infancy to resemble a normal, healthy microbiome. However, one of the fundamental issues in microbiome research is characterizing what a "normal" infant microbiome is based on geography, ethnicity and cultural variations. This review provides a comprehensive account of what is currently known about the infant microbiome from a global context. In general, this review shows that the influence of cultural variations in feeding practices, delivery modes and hygiene are the biggest contributors to microbial variability. Despite geography or race, all humans have similar microbial succession during infancy.

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Linking fat intake, the intestinal microbiome, and necrotizing enterocolitis in premature infants

Cited by 14 publications

References 59 publications

Impact of maternal nutrition in pregnancy and lactation on offspring gut microbial composition and function

Impact of maternal nutrition in pregnancy and lactation on offspring gut microbial composition and function

Mosapride combined with probiotics on gastrointestinal function and growth in premature infants

Human behavior, not race or geography, is the strongest predictor of microbial succession in the gut bacteriome of infants

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