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Fielding, Nigel; Fielding, Jane

doi:10.4135/9781412984775

Cited by 560 publications

(264 citation statements)

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“…Comparative research is an acknowledgement of the numerous problems of translation of evidence. Comparison can strengthen reliability, but there is often disagreement when the data do not come together as an integrated whole 24 . Focusing on what is learned by the degree of convergence rather than forcing a dichotomous choice typically yields a more balanced result overall 23 .…”

Section: Discussionmentioning

confidence: 99%

A Mixed-Methods Cohort Study to Determine Perceived Patient Benefit in Providing Custom Breast Prostheses

Kubon

McClennen²,

Fitch

et al. 2012

Current Oncology

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ConclusionsThe qualitative data provide a strong case in support of the new device. Patient demand, perceived benefit, and experience wearing the prosthesis were documented. Suggestions for improvements in the device and in the program operations were gathered and will influence future development of this service. KEY WORDSMastectomy, custom breast prosthesis, mixed methodology, cancer rehabilitation, quality of life

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Section: Discussionmentioning

confidence: 99%

A Mixed-Methods Cohort Study to Determine Perceived Patient Benefit in Providing Custom Breast Prostheses

Kubon

McClennen²,

Fitch

et al. 2012

Current Oncology

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“…The member check is a verification method that involves sending each participant a copy of the manuscript and asking for feedback on whether the description of his or her experience was expressed accurately and without embellishment (Bloor, 1997). According to Fielding and Fielding (1986), this process should be treated "as yet another source of data and insight" (p. 43). Each participant individually member-checked his or her transcript; six participants gave feedback and/or clarification.…”

Section: Suspending Disbelief and Employing Intense Interestmentioning

confidence: 99%

An existential phenomenological examination of parkour and freerunning

Clegg

Butryn

2012

Qualitative Research in Sport, Exercise and Health

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Therefore, the purpose of this study was to expand sport and edgework research by qualitatively examining the lived, sporting experiences of parkour practitioners.Phenomenological interviews were conducted with 11 (9 male, 2 female) intermediate-to-advanced traceurs (parkour practioners) ranging from 18 to 33 years old.Two dimensions emerged: bodily experience and interactive experience. Several supporting themes also emerged, including play, movement, and risk within the bodily experience dimension, and community, public, and world within the interactive experience dimension. The findings of this study provide new perspectives on the experiences and meanings associated with participating in parkour and freerunning.v ACKNOWLEDGEMENTS

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“…Recent research has demonstrated two lipoprotein subclasses containing apoB-100: B,E particles containing apoE and -B and B particles lacking apoE (10)(11)(12). The presence of apoE has been shown to have a profound influence on the removal of apoB-100 in VLDL particles from the blood of normal rabbits and their conversion to lipoproteins of higher density [intermediate density lipoprotein (IDL) and LDL] (10).…”

mentioning

confidence: 99%

Increased clearance of plasma cholesterol after injection of apolipoprotein E into Watanabe heritable hyperlipidemic rabbits.

Yamada

Shimano

Mikami

et al. 1989

Proc. Natl. Acad. Sci. U.S.A.

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Apolipoprotein E (apoE) is known to play an important role in lipoprotein metabolism. We have studied the effect of apoE on the metabolism of plasma cholesterol by injecting apoE intravenously into rabbits deficient in low density lipoprotein receptors [Watanabe heritable hyperlipidemic (WHHL) rabbits]. Approximately 30 mg of apoE was injected per rabbit; a total of five WHHL rabbits were used. One hour later, plasma cholesterol levels fell 8.3% (from 488 ± 192 to 446 ± 174 mg/dl). After 3 hr, cholesterol levels had fallen by 19% (to 392 ± 152 mg/dl). The reduced levels were maintained for at least 8 hr after injection of apoE. Cholesterol in very low density lipoproteins (VLDLs) and intermediate density lipoproteins fell rapidly during the first 2 hr after injection, followed by a reduction in the low density lipoprotein cholesterol level. Changes in apolipoprotein B levels in each lipoprotein fraction were very similar to those of cholesterol.Plasma apoE levels 3 min after injection were elevated 3-fold to 22.8 ± 6.3 mg/dl and returned to initial levels 8 hr after injection. The rate of removal of intravenously injected 1251 labeled VLDL that had been incubated with apoE was 3-fold higher than that of unmodified VLDL. From these results, we conclude that the injected apoE is incorporated into VLDLs and that VLDL particles carrying more apoE are removed from the blood more rapidly, resulting in reduced formation of low density lipoprotein and lowered cholesterol levels.Low density lipoprotein (LDL) cholesterol is mainly removed from blood plasma by hepatic LDL receptors that interact with two specific ligands on lipoproteins, apolipoprotein B-100 (apoB-100) and apolipoprotein E (apoE) (1-3). Lipoproteins rich in apoE, such as large very low density lipoprotein (VLDL) and ,B-VLDL, have a much higher affinity for LDL receptors than LDL, which contains only apoB-100 (4, 5). In addition, lipoproteins containing apoE can bind to receptors on the liver cell membranes that are responsible for the uptake of dietary cholesterol carried in chylomicron remnants (6,7). This chylomicron-remnant receptor is thought to be distinct from the LDL receptor because chylomicron remnants are normally removed from the blood in human familial hypercholesterolemia (8) and in Watanabe heritable hyperlipidemic (WHHL) rabbits deficient in LDL receptors (9).Recent research has demonstrated two lipoprotein subclasses containing apoB-100: B,E particles containing apoE and -B and B particles lacking apoE (10-12). The presence of apoE has been shown to have a profound influence on the removal of apoB-100 in VLDL particles from the blood of normal rabbits and their conversion to lipoproteins of higher density [intermediate density lipoprotein (IDL) and LDL] (10). In WHHL rabbits, the rate of removal of VLDL-B,E particles from the blood was 4-fold higher than that of VLDL-B particles (11). These results suggest that in WHHL rabbits a small number of LDL receptors expressed on the surface of hepatocytes or chylomicron-remnant receptors p...

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Linking Data

Cited by 560 publications

References 0 publications

A Mixed-Methods Cohort Study to Determine Perceived Patient Benefit in Providing Custom Breast Prostheses

A Mixed-Methods Cohort Study to Determine Perceived Patient Benefit in Providing Custom Breast Prostheses

An existential phenomenological examination of parkour and freerunning

Increased clearance of plasma cholesterol after injection of apolipoprotein E into Watanabe heritable hyperlipidemic rabbits.

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