Linking Basement Membrane and Slit Diaphragm in Drosophila Nephrocytes
Claire Leroy,
Konrad Lang,
Dominik Spitz
et al.
Abstract:Background:
The glomerular basement membrane and the slit diaphragm are essential parts of the filtration barrier. How these layers collaborate remains unclear. The podocyte-like nephrocytes in Drosophila harbor both a slit diaphragm and a basement membrane, serving as a model to address this critical question.
Methods:
Basement membrane components and matrix receptors were silenced using RNAi in nephrocytes. Slit diaphragms were analyzed by immunofluor… Show more
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