Linkers with Optical Functionality

MOF materials as therapeutic agents, drug carriers, imaging agents and biosensors in cancer biomedicine: Recent advances and perspectives

“…MOF materials are already being successfully used as potential bioimaging and sensing agents [54,57,66]. In particular, imaging agents can be introduced into the structure (metals, ligands) at the synthesis as well as post-synthesis stage (adsorption, modification).…”

“…In particular, imaging agents can be introduced into the structure (metals, ligands) at the synthesis as well as post-synthesis stage (adsorption, modification). The techniques using MOF materials as contrast agents and/or sensors [54,57,66] are as follows:…”

“…MOF materials are promising contrast agents because they offer a possibility of affecting both T1 and T2, and more information can be obtained from MRI. However, even more important is that the application of MOFs offers simultaneous imaging and delivery of active agents [54,57,66].…”

“…Usually the dyes absorbing visible light are used, however, the weak visible light permeability of tissues pose certain limitations on the applicability of the method and near IR can be applied instead during in vivo imaging. Another technical issue one has to be aware of is the dilution of the dye, which leads to imaging sensitivity decrease [54,57,66].…”

“…In general, luminescent MOF materials are being extensively researched at the moment in the context of several optical imaging applications [54,57,66]. Two major strategies have been explored to produce luminescent MOF.…”