Linked transmission chains of imported SARS-CoV-2 variant B.1.351 across mainland France, January 2021

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doi:10.2807/1560-7917.es.2021.26.13.2100333

Cited by 7 publications

(3 citation statements)

References 12 publications

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“… 35 One study from France reported the incubation period of 4.50 days (95% CI, 1.83-7.17 days) for COVID-19 caused by the Beta variant. 113 Another study reported the incubation period of COVID-19 caused by the Beta/Gamma variant was 5.10 days (95% CI, 4.87-5.33 days). 35 …”

Section: Resultsmentioning

confidence: 99%

“…Most of the studies (93 [65.5%]) were conducted between January and March 2020 and most were conducted in China (108 [76.1%]). One study used case data from multiple countries around the world, 81 6 studies were conducted in South Korea, 37 , 46 , 51 , 52 , 59 , 124 4 in France, 25 , 29 , 35 , 113 3 in Japan, 80 , 105 2 in Singapore, 87 , 111 2 in India, 16 , 78 , 83 , 103 2 in Vietnam, 21 , 58 and 2 in Australia. 45 , 99 One hundred nineteen studies (83.8%) included patients infected with the wild-type strain, 5 (3.5%) with the multiple strains, 17 , 26 , 35 , 80 , 112 and 11 (7.7%) with an unknown strain 84 , 93 , 99 , 106 , 116 , 126 , 135 , 142 , 148 , 150 , 157 (eTable 4 in the Supplement ).…”

Section: Resultsmentioning

confidence: 99%

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Incubation Period of COVID-19 Caused by Unique SARS-CoV-2 Strains

et al. 2022

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Incubation Period of COVID-19 Caused by Unique SARS-CoV-2 Strains

et al. 2022

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“…In France, the incidence of COVID-19 and its mortality started rising for the third time in January 2021. This coincided with the first confirmed cases of infection with the South African VOC Beta, which arose in a group of individuals who had traveled in December 2020 to Mozambique (which shares a border with South Africa) for a religious gathering ( 10 ). This transmission event specifically changed the VOC distribution in the northeast of France.…”

Section: Introductionmentioning

confidence: 61%

Comparison of SARS-CoV-2 Variants of Concern Alpha (B.1.1.7) vs. Beta (B.1.351) in Critically Ill Patients: A Multicenter Cohort Study

et al. 2022

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ObjectivesThe clinical outcomes of the Beta (B.1.351) variant of concern (VOC) of the SARS-CoV-2 virus remain poorly understood. In early 2021, northeastern France experienced an outbreak of Beta that was not observed elsewhere. This outbreak slightly preceded and then overlapped with a second outbreak of the better understood VOC Alpha (B.1.1.7) in the region. This situation allowed us to contemporaneously compare Alpha and Beta in terms of the characteristics, management, and outcomes of critically ill patients.MethodsA multicenter prospective cohort study was conducted on all consecutive adult patients who had laboratory confirmed SARS CoV-2 infection, underwent variant screening, and were admitted to one of four intensive care units (ICU) for acute respiratory failure between January 9th and May 15th, 2021. Primary outcome was 60-day mortality. Differences between Alpha and Beta in terms of other outcomes, patient variables, management, and vaccination characteristics were also explored by univariate analysis. The factors that associated with 60-day death in Alpha- and Beta-infected patients were examined with logistic regression analysis.ResultsIn total, 333 patients (median age, 63 years; 68% male) were enrolled. Of these, 174 and 159 had Alpha and Beta, respectively. The two groups did not differ significantly in terms of 60-day mortality (19 vs. 23%), 28-day mortality (17 vs. 20%), need for mechanical ventilation (60 vs. 61%), mechanical ventilation duration (14 vs. 15 days), other management variables, patient demographic variables, comorbidities, or clinical variables on ICU admission. The vast majority of patients were unvaccinated (94%). The remaining 18 patients had received a partial vaccine course and 2 were fully vaccinated. The vaccinated patients were equally likely to have Alpha and Beta.ConclusionsBeta did not differ from Alpha in terms of patient characteristics, management, or outcomes in critically ill patients.Trial RegistrationClinicalTrials.gov, identifier: NCT04906850.

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Assessing changes in incubation period, serial interval, and generation time of SARS-CoV-2 variants of concern: a systematic review and meta-analysis

Kummer

Zhao

et al. 2023

Preprint

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Background: After the first COVID-19 wave caused by the ancestral lineage, the pandemic has been fueled from the continuous emergence of new SARS-CoV-2 variants. Understanding key time-to-event periods for each emerging variant of concern is critical as it can provide insights into the future trajectory of the virus and help inform outbreak preparedness and response planning. Here, we aim to examine how the incubation period, serial interval, and generation time have changed from the ancestral SARS-CoV-2 lineage to different variants of concern. Methods: We conducted a systematic review and meta-analysis that synthesized the estimates of incubation period, serial interval, and generation time (both realized and intrinsic) for the ancestral lineage, Alpha, Beta, and Omicron variants of SARS-CoV-2. Results: Our study included 274 records obtained from 147 household studies, contact tracing studies or studies where epidemiological links were known. With each emerging variant, we found a progressive shortening of each of the analyzed key time-to-event periods. Specifically, we found that Omicron had the shortest pooled estimates for the incubation period (3.63 days, 95%CI: 3.25-4.02 days), serial interval (3.19 days, 95%CI: 2.95-3.43 days), and realized generation time (2.96 days, 95%CI: 2.54-3.38 days) whereas the ancestral lineage had the highest pooled estimates for each of them. We also observed shorter pooled estimates for the serial interval compared to the incubation period across the virus lineages. We found considerable heterogeneities (I2 > 80%) when pooling the estimates across different virus lineages, indicating potential unmeasured confounding from population factors (e.g., social behavior, deployed interventions). Conclusion: Our study supports the importance of conducting contact tracing and epidemiological investigations to monitor changes in SARS-CoV-2 transmission patterns. Our findings highlight a progressive shortening of the incubation period, serial interval, and generation time, which can lead to epidemics that spread faster, with larger peak incidence, and harder to control. We also consistently found a shorter serial interval than incubation period, suggesting that a key feature of SARS-CoV-2 is the potential for pre-symptomatic transmission. These observations are instrumental to plan for future COVID-19 waves. Keywords: COVID-19, variants of concern, incubation period, serial interval, realized generation time, intrinsic generation time, systematic review, meta-analysis

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Linked transmission chains of imported SARS-CoV-2 variant B.1.351 across mainland France, January 2021

Cited by 7 publications

References 12 publications

Incubation Period of COVID-19 Caused by Unique SARS-CoV-2 Strains

Incubation Period of COVID-19 Caused by Unique SARS-CoV-2 Strains

Comparison of SARS-CoV-2 Variants of Concern Alpha (B.1.1.7) vs. Beta (B.1.351) in Critically Ill Patients: A Multicenter Cohort Study

Assessing changes in incubation period, serial interval, and generation time of SARS-CoV-2 variants of concern: a systematic review and meta-analysis

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