Linked Color Imaging Focused on Neoplasm Detection in the Upper Gastrointestinal Tract

Ono, Shoko; Kawada, Kenro; Dohi, Osamu; Kitamura, Shinji; Koike, Tomoyuki; Hori, Shinichiro; Kanzaki, Hiromitsu; Murao, Takahisa; Yagi, Nobuaki; Sasaki, Fumisato; Hashiguchi, Keiichi; Oka, Shiro; Katada, Kazuhiro; Shimoda, Ryo; Mizukami, Kazuhiro; Suehiro, Mitsuhiko; Takeuchi, Toshihisa; Katsuki, Shinichi; Tsuda, Momoko; Naito, Yuji; Kawano, Tatsuyuki; Haruma, Ken; Ishikawa, Hideki; Mori, Keita; Kato, Mototsugu

doi:10.7326/m19-2561

Cited by 72 publications

(97 citation statements)

References 26 publications

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“…Recently, early stage HNCs, including superficial cancers or carcinoma in situ, have become detectable with advanced endoscopic technology, such as narrow band imaging (NBI) 19 , 20 , 21 or linked color imaging (LCI). 22 For these early stage cancers, endoscopic surgeries can be performed as less invasive alternatives to conventional surgery. 6 Endoscopic NIR‐PIT has the potential to be applied to such early stage HNCs as well.…”

Section: Discussionmentioning

confidence: 99%

Endoscopic near‐infrared photoimmunotherapy in an orthotopic head and neck cancer model

et al. 2021

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Near‐infrared photoimmunotherapy (NIR‐PIT) is a cell selective cancer therapy that uses an antibody‐photoabsorber (IRDye700DX, IR700) conjugate (APC) and NIR light. NIR‐PIT targeting epidermal growth factor receptor (EGFR) in head and neck cancer (HNC) was conditionally approved in Japan in 2020. APC‐bound tumors can be detected using endoscopic fluorescence imaging, whereas NIR light can be delivered using endoscopic fiber optics. The aims of this study were: (1) to assess the feasibility of endoscopic NIR‐PIT in an orthotopic HNC model using a CD44‐expressing MOC2‐luc cell line; and (2) to evaluate quantitative fluorescence endoscopic imaging prior to and during NIR‐PIT. The results were compared in 3 experimental groups: (1) untreated controls, (2) APC injection without light exposure (APC‐IV), and (3) APC injection followed by NIR light exposure (NIR‐PIT). APC injected groups showed significantly higher fluorescence signals for IR700 compared with the control group prior to therapeutic NIR light exposure, and the fluorescence signal significantly decreased in the NIR‐PIT group after light exposure. After treatment, the NIR‐PIT group showed significantly attenuated bioluminescence compared with the control and the APC‐IV groups. Histology demonstrated diffuse necrotic death of the cancer cells in the NIR‐PIT group alone. In conclusion, endoscopically delivered light combined with quantitative fluorescence imaging can be used to “see and treat” HNC. This method could also be applied to other types of cancer approachable with endoscopy.

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Section: Discussionmentioning

confidence: 99%

Endoscopic near‐infrared photoimmunotherapy in an orthotopic head and neck cancer model

et al. 2021

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“…It supports image-enhanced functions, such as linked color imaging (LCI) or blue-light imaging (BLI), which are effective for the detection and characterization of polyps. 15 – 19 The image signal from the processor was input to a personal computer EX-1 (FUJIFILM Co., Tokyo, Japan), and dedicated software was installed to estimate the distance in real-time. The output of the image signal was displayed on a monitor with a suitable representation of the virtual scale.…”

Section: Methodsmentioning

confidence: 99%

Virtual scale function of gastrointestinal endoscopy for accurate polyp size estimation in real-time: a preliminary study

et al. 2021

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Significance: Polyp size is important for selecting the surveillance interval or treatment policy. Nevertheless, it is challenging to accurately estimate the polyp size during endoscopy. An easy and cost-effective function to assist in polyp size estimation is required.Aim: To propose a virtual scale function for endoscopy and evaluate its performance and expected accuracy.Approach: An adaptive virtual scale behavior was demonstrated. The measurement error of the virtual scale along the distance between the tip of the endoscope and the object plane was evaluated using graph paper. The accuracy of polyp size estimation by an expert endoscopist was compared with the accuracy of the biopsy forceps method using phantom images. Results:The measurement errors of the virtual scale were ≤ 0.7 mm when the distance to the graph paper, which faced the tip of the endoscope, varied from 4 to 30 mm. The accuracy with the virtual scale was significantly higher than that obtained with biopsy forceps (5.3 AE 5.5% versus 11.9 AE 9.4%, P < 0.001). Conclusions:The virtual scale function, which operates in real-time without any additional device, can be used to estimate polyp sizes easily and accurately with endoscopy.

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“…IEE techniques are useful for enhancing images of vasculature patterns, and for improving the visibility of surface patterns and color differences. Several IEE modalities are used in daily clinical practice, including narrow-band imaging (NBI, Olympus Corp., Tokyo, Japan), flexible spectral color enhancement (FICE, Fujifilm Corp., Tokyo, Japan), blue laser imaging (BLI, Fujifilm Corp., Tokyo, Japan), and linked color imaging (LCI, Fujifilm Corp., Tokyo, Japan) [17][18][19][20][21]. However, the diagnostic efficacy of CE is reduced when the identification of the mucosa is impaired due to the interference of bubbles, food residues, bile, and blood.…”

Section: Introductionmentioning

confidence: 99%

Image-Enhanced Capsule Endoscopy Improves the Identification of Small Intestinal Lesions

et al. 2021

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Image-enhanced endoscopy is useful for diagnosing and identifying lesions in the gastrointestinal tract. Recently, image-enhanced endoscopy has become a breakthrough technology that has attracted significant attention. This image enhancing technology is available for capsule endoscopy, which is an effective tool for small intestinal lesions and has been applied in flexible spectral color enhancement technology and in contrast capsule like narrow-band imaging. In this field, most researchers focus on improving the visibility and detection of small intestinal lesions. This review summarizes previous studies on image-enhanced capsule endoscopy and aims to evaluate the efficacy of this technology.

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Linked Color Imaging Focused on Neoplasm Detection in the Upper Gastrointestinal Tract

Cited by 72 publications

References 26 publications

Endoscopic near‐infrared photoimmunotherapy in an orthotopic head and neck cancer model

Endoscopic near‐infrared photoimmunotherapy in an orthotopic head and neck cancer model

Virtual scale function of gastrointestinal endoscopy for accurate polyp size estimation in real-time: a preliminary study

Image-Enhanced Capsule Endoscopy Improves the Identification of Small Intestinal Lesions

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