Linkage to the incompatibility factors and maintenance of genetic variation in selection lines of Schizophyllum commune

Connolly, V.; Simchen, Giora

doi:10.1038/hdy.1968.51

Cited by 11 publications

(8 citation statements)

References 14 publications

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“…Similar findings were reported for the control of ascospore size in Neurospora crassa (PATEMAN, 1959;LEE, 1962). In addition, linkage of polygenes to known genetic markers has been demonstrated in these fungi (SIMCHEN, 1966;LEE & PATEMAN, 1959;CONNOLLY • SIMCHEN, 1968). This paper presents data on linkage of part of the polygenic system controlling fast linear growth rate in Neurospora crassa to the aurescent (albino-1) locus on chromosome I and on the absence of linkage to the yellow locus on chromosome VI.…”

Section: Introductionsupporting

confidence: 64%

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Growth rate in Neurospora crassa: Linkage of polygenes

Papa

1971

Genetica

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Section: Introductionsupporting

confidence: 64%

“…The difference of .08 mm/hr between aur + F1 and aur-F1 was not statistically significant. This was not surprising, however, in view of the fact that the analysis employed was not too sensitive for testing linkage, particularly when the "background" genetic variance is high (CONNOLLY & SIMCHEN, 1968).…”

Section: Resultsmentioning

confidence: 99%

Growth rate in Neurospora crassa: Linkage of polygenes

Papa

1971

Genetica

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“…The light-induced SA growth state presumably occurs only when the dikaryotic mycelium grows out of growth rates (Simchen and Jinks 1964), while in monokaryons gene interactions (epistasis) were the main the substrate and is exposed to light, at which time fruit bodies are produced. We suspect that, as the predomisource of variance in growth rates (Simchen 1966). Further, dikaryons made from haploids taken from differnant, nutrient assimilating form, the FS state has been shaped more strongly than the SA state by stabilizing ent geographic areas also showed epistatic interactions for growth rate (Simchen 1967).…”

Section: Dik-1 and Dik-3 Consistent With The Mutations Identi-mentioning

confidence: 99%

“…ism for transmission genetics, developmental biology, and population genetics (Raper and Miles 1958;Raper 1966Raper , 1988Simchen 1966) and has also been used in…”

mentioning

confidence: 99%

Dikaryons of the Basidiomycete Fungus Schizophyllum commune

Clark

Anderson

2004

Genetics

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The impact of ploidy on adaptation is a central issue in evolutionary biology. While many eukaryotic organisms exist as diploids, with two sets of gametic genomes residing in the same nucleus, most basidiomycete fungi exist as dikaryons in which the two genomes exist in separate nuclei that are physically paired and that divide in a coordinated manner during hyphal extension. To determine if haploid monokaryotic and dikaryotic mycelia adapt to novel environments under natural selection, we serially transferred replicate populations of each ploidy state on minimal medium for 18 months ‫000,31ف(‬ generations). Dikaryotic mycelia responded to selection with increases in growth rate, while haploid monokaryotic mycelia did not. To determine if the haploid components of the dikaryon adapt reciprocally to one another's presence over time, we recovered the intact haploid components of dikaryotic mycelia at different time points (without meiosis) and mated them with nuclei of different evolutionary histories. We found evidence for coadaptation between nuclei in one dikaryotic line, in which a dominant deleterious mutation in one nucleus was followed by a compensatory mutation in the other nucleus; the mutant nuclei that evolved together had the best overall fitness. In other lines, nuclei had equal or higher fitness when paired with nuclei of other histories, indicating a heterozygote advantage. To determine if genetic exchange occurs between the two nuclei of a dikaryon, we developed a 24-locus genotyping system based on single nucleotide polymorphisms to monitor somatic exchange. We observed genetic exchange and recombination between the nuclei of several different dikaryons, resulting in genotypic variation in these mitotic cell lineages.

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“…From each parental dikaryon monokaryons were isolated and their mating types determined as described by Connolly and Simchen (1968). Six monokaryons of A12B11 mating type from 3-6L, the low growth-rate parent, and six of A11B12 mating type from 3-6H, the high growth-rate parent, were mated in all compatible combinations (i.e.…”

Section: Regression Approachesmentioning

confidence: 99%