Linkage study of cancer risk among lead-exposed workers in New Jersey

Lam, Thuy; Agovino, Pamela K.; Niu, Xiaoling; Roche, L

doi:10.1016/j.scitotenv.2006.10.018

Cited by 44 publications

(30 citation statements)

References 21 publications

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“…An early review by Wong and Raabe (2000), which was confined to lead exposure related to petroleum workers, reported no association. Another investigation (Siddiqui et al, 2002) from India, concluded that environmental exposure of ageing males to lead might be a risk factor, but more recent studies by Lam et al (2007) and Gwini et al (2012) reported that lead was not associated with prostate cancer. Overall, the evidence pertaining to lead is inconsistent and it is unlikely occupational exposure to lead is associated with prostate cancer incidence.…”

Section: Heavy and Toxic Metalsmentioning

confidence: 99%

An Update on Occupation and Prostate Cancer

Doolan¹,

Benke²,

Giles³

2014

Asian Pacific Journal of Cancer Prevention

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Background: Our aim was to identify gaps and limitations in the current literature and to make recommendations for future research required to address these. Materials and Methods: We reviewed occupational exposures and related factors associated with the risk of prostate cancer between 2000 and 2012. These included chemical, ergonomic, physical or environmental, and psychosocial factors which have been reported by epidemiological studies across a range of industries. Results: The results are inconsistent from study to study and generally this is due to the reliance upon the retrospectivity of case-control studies and prevalence (ecological) studies. Exposure assessment bias is a recurring limitation of many of the studies in this review. Conclusions: We consider there is insufficient evidence to implicate prostate cancer risk for ergonomic, physical, environmental or psychosocial factors, but there is sufficient evidence to implicate toxic metals, polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs). More research is required to identify specific pesticides that may be associated with risk of prostate cancer.

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Section: Heavy and Toxic Metalsmentioning

confidence: 99%

An Update on Occupation and Prostate Cancer

Doolan¹,

Benke²,

Giles³

2014

Asian Pacific Journal of Cancer Prevention

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“…It has been well documented that prolonged exposure in humans to lead can cause anemia, reproductive impairment, renal failure, and neurodegenerative damage (Lam et al, 2007). High concentrations of Pb occur unnaturally in soils through mining and smelting activities, combustion of leaded gasoline, land application of sewage sludge, and disposal of batteries and other Pb-bearing products (Lin et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Bioremediation of lead by ureolytic bacteria isolated from soil at abandoned metal mines in South Korea

Kang

Shin

et al. 2015

Ecological Engineering

148

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“…To date, most of the focus on metals and prostate cancer risk has been on Cd [31,61,15], and few epidemiological studies have assessed associations between Pb and prostate cancer risk [35,36]. Surprisingly, most of the evidence against an association between Pb and prostate cancer has come from retrospective studies that failed to find higher prostate cancer mortality rates in Pb exposed workers [62-66].…”

Section: Discussionmentioning

confidence: 99%

“…Epidemiological studies of the association between Cd [31-34] and Pb [35,36] and prostate cancer have shown mixed results but no study to date has accounted for genetic variation that may predispose some men to greater pathological or physiological effects of these metals. Therefore, using a statistically efficient case-only design, we evaluated the potential for an interaction between the JAZF1 rs10486567 polymorphism and sources of Cd and Pb exposure in African American prostate cancer cases, and case-control analyses were carried out to validate the case-only findings.…”

Section: Introductionmentioning

confidence: 99%

Gene–environment interactions between JAZF1 and occupational and household lead exposure in prostate cancer among African American men

Neslund‐Dudas

Levin

Beebe‐Dimmer

et al. 2014

Cancer Causes Control

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Purpose A single nucleotide polymorphism, rs10486567, in JAZF1 has consistently been associated with increased risk of prostate cancer. The physical interaction of zinc finger proteins, such as JAZF1, with heavy metals may play a role in carcinogenesis. This study assessed potential gene-environment statistical interactions (GxE) between rs10486567 and heavy metals in prostate cancer. Methods In a case-only study of 228 African American prostate cancer cases, GxE between rs10486567 and sources of cadmium (Cd) and lead (Pb) were assessed. Unconditional logistic regression was used to estimate interaction odds ratios and GEE was used for models containing nested data. Case-control validation of IORs was performed, using 82 controls frequency matched to cases on age-race. Results Among cases, a potential GxE interaction was observed between rs10486567 CC genotype and living in a Census tract with a high proportion of housing built before 1950, a proxy for household Pb exposure, when compared to CT or TT carriers (OR 1.81; 95% CI 1.04-3.16; p=0.036). A stronger GxE interaction was observed when both housing and occupational Pb exposure were taken into account (OR 2.62; 95% CI 1.03-6.68; p=0.04). Case-control stratified analyses showed the odds of being a CC carrier was higher in cases compared to controls among men living in areas with older housing (OR 2.03; CI 0.99-4.19; p=0.05) or having high occupational Pb exposure (OR 2.50; CI 1.01-6.18; p=0.05). Conclusions In African American men, the association between JAZF1 rs10486567 and prostate cancer may be modified by exposure to heavy metals such as Pb.

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Linkage study of cancer risk among lead-exposed workers in New Jersey

Cited by 44 publications

References 21 publications

An Update on Occupation and Prostate Cancer

An Update on Occupation and Prostate Cancer

Bioremediation of lead by ureolytic bacteria isolated from soil at abandoned metal mines in South Korea

Gene–environment interactions between JAZF1 and occupational and household lead exposure in prostate cancer among African American men

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