Linkage of Some Trace Elements and Cardiac Markers in Assessment of Acute Coronary Syndromes

Abstract

Background: Acute coronary syndrome (ACS) is accounting for any condition causing sudden reduced blood flow to the heart. Some trace elements play role in the development of ACS. Aim: This study aimed to evaluate the linkage between serum zinc, copper, iron level and cardiac markers in acute coronary syndromes. Methods: Eighty patients were divided into four groups. Group I (patients with unstable angina), Group II (acute myocardial infarction early 6 h), group III (acute myocardial infarction late 6 h) and group IV (patients with reperfusion therapy). Fifteen apparently healthy individuals served as a control group. Different risk factors as age, sex, diabetes and dyslipideamia were addressed in different groups. The correlation between Fe, Zn and Cu versus cardiac enzymes were demonstrated. The receiver operating characteristic (ROC) analysis was conducted. Results: Male and diabetic patients were significantly higher. The CK and Tn were significantly increased in groups I, II and III. The CK-MB levels were significantly increased in group II and group III. The AST levels were significantly increased in group III. The serum iron level was significantly lower in group I, II and III. Serum zinc show slight decrease in groups II and III. No significant correlation was obtained concerning serum Cu. In group II, there were significant positive correlation between Fe versus Tn, CK-MB and CK. The (ROC) analysis was identified the optimal Fe, Zn and Cu plasma level for potential prediction of development of ACS. Conclusion: Fe and Zn values were lower in ACS patients. Cu values did not show difference.

Serum soluble ST2 as a potential mediator in prediction of heart failure after acute ST elevation myocardial infarction and primary percutaneous coronary intervention

“…One of promising biomarkers of left ventricular and infarct remodeling after acute myocardial infarction is Serum soluble ST2 [3] . Some biomarkers considered as a valuable tool that can help physicians to address more efficiently the management of the different stages of the heart failure, from early detection and diagnosis to risk prediction and also guiding therapy [4,5] . Although ST2 effect is strongly belonged to IL-33 mechanism, its action in cardiac muscle is complicated and not enough clarified.…”