Linkage of Lower Urinary Tract Symptoms to Sleep Quality in Elderly Men with Nocturia: A Community Based Study Using Home Measured Electroencephalogram Data

Matsushita, Chie; Torimoto, Kazumasa; Goto, Daisuke; Morizawa, Yosuke; Kiba, Keisuke; Shinohara, Masatake; Hirayama, Akihide; Kurumatani, Norio; Fujimoto, Kiyohide

doi:10.1016/j.juro.2016.07.088

Cited by 17 publications

(20 citation statements)

References 17 publications

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“…Deep sleep, or restorative SWS, predominates in the first 3‐to‐4 hours of sleep . Disruption of deep sleep, for instance by nocturia, is likely to have a greater negative impact on sleep quality and general well‐being than waking up during rapid eye movement or light sleep . In our study, OAB treatment increased FUST, suggesting that participants were more likely to wake up during light sleep than deep sleep, which might subsequently lead to better overall health and quality of life.…”

Section: Discussionmentioning

confidence: 58%

“…Previous studies have consistently demonstrated a close relationship between nocturia and sleep . Interrupted sleep due to nocturia has been linked to fatigue, decreased concentration, lower performance at work and increased risk of accidents .…”

Section: Discussionmentioning

confidence: 99%

“…Time to first nocturia episode, quantified as FUST, is an important predictor in perceived sleep quality . Deep sleep, or restorative SWS, predominates in the first 3‐to‐4 hours of sleep . Disruption of deep sleep, for instance by nocturia, is likely to have a greater negative impact on sleep quality and general well‐being than waking up during rapid eye movement or light sleep .…”

Section: Discussionmentioning

confidence: 99%

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Does successful treatment of overactive bladder improve co‐morbidities in patients with nocturia?

et al. 2019

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Objective To investigate whether treatment of overactive bladder (OAB), one comorbidity of nocturia, could reduce waking to void and improve other co‐existing symptoms. Methods A prospective cohort study was conducted at Royal Melbourne Hospital. Participants received 12 weeks of standard treatment, including lifestyle interventions and pharmacotherapy. Outcome measures were nocturia episodes, severity of urinary urgency/incontinence, sleep quality, daytime somnolence, anxiety and depression scores, quality of life and change in blood pressure. Results Twenty participants completed the study. Nocturia frequency improved by one void per night. Overactive Bladder Symptom Score, sleep quality, first uninterrupted sleep time and systolic blood pressures improved. There were no significant changes in daytime somnolence, mood or quality of life. Conclusions In this pilot study, nocturia and other co‐morbid dysfunctions appeared to improve when the severity of OAB was reduced. Treatment of OAB co‐morbid with nocturia reduces urinary symptoms and may improve sleep parameters and positively impact return to health.

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Does successful treatment of overactive bladder improve co‐morbidities in patients with nocturia?

et al. 2019

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“…Therefore, it is difficult for nocturia patients who go to the toilet for voiding to undergo polysomnography, which fixes patients to the bed during the sleep period. The portable EEG device used in this study does not restrain patients and was demonstrated as useful in our previous study, which demonstrated the linkage between sleep quality assessed by the PSQI and slow-wave sleep time [14].…”

Section: Discussionmentioning

confidence: 96%

Rationale, design, and methods of electroencephalography-based investigation of the effects of oral desmopressin on improving slow-wave sleep time in nocturnal polyuria patients (the DISTINCT study): protocol for a single-arm, open-label, single-assignment trial

et al. 2020

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Background: Nocturia is one of the most bothersome lower urinary tract symptoms and often impairs sleep quality in the elderly. Although previous studies on nocturia have indicated that the successful treatment of nocturia improves sleep quality, most used questionnaires and activity devices to analyze sleep/wake patterns. Therefore, there is little information about the treatment effects of desmopressin on objective sleep quality. The aim of the DISTINCT study is to investigate the change in subjective and objective sleep quality using electroencephalography (EEG) and the Pittsburgh Sleep Quality Index (PSQI) after the administration of desmopressin in patients with nocturia due to nocturnal polyuria. Methods: A total of 20 male patients, ≥65 years old, with nocturnal polyuria, defined as a nocturnal polyuria index (NPi) (nocturnal urine volume / 24 h urine volume) value ≥0.33, will participate in this study. The participants must have a nocturnal frequency of ≥2 and the first uninterrupted sleep period (FUSP) must occur within < 2.5 h. Desmopressin 50 μg per day will be orally administered before going to bed for 4 weeks. Urinary frequency volume charts (FVC) and EEG will be recorded prior to treatment and at 1 week and 4 weeks after the initiation of treatment. The PSQI will be completed before and 4 weeks after treatment. The primary endpoint is the change from baseline in the mean time of slow-wave sleep (sleep stages N3 and N4) at 4 weeks. The secondary endpoints include the change in the mean value of each sleep variable, the mean delta power during the FUSP, the correlation between nocturnal urinary frequency and slow-wave sleep time, and the change in PSQI score before and after treatment.

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“…5 Restless sleep, long latency before falling and returning to sleep, and shorter total duration of sleep all correlate with high bother in men with nocturia. 5,6 Furthermore, the link between poor sleep and depression has been well described. 7 Successful treatment of nocturnal polyuria, the most prevalent underlying cause of nocturia, has been shown to increase time slept before an individual's first nocturia episode (first undisturbed sleep time or FUST).…”

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confidence: 99%

Nocturnal voiding frequency does not describe nocturia‐related bother

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et al. 2019

Neurourology and Urodynamics

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Aim Nocturia frequency has been used as a measure of treatment efficacy for nocturia even though fluctuation of the symptom over time has been well described in the literature. Additionally, given the multifactorial causal pathway and clinically relevant comorbidities, frequency alone may be an insufficient marker of treatment direction. The aim of this study was to investigate factors associated with nocturia‐related bother to identify additional variables that may capture the impact of nocturia, direct clinical care and have potential to quantify treatment outcome. Methods Prospective data from tertiary hospital Urology and Continence cohorts were matched for identical variables to generate a sample of 204 datasets. Descriptive statistics were obtained to describe the two cohorts. Characteristics of patients were evaluated across levels of nocturia frequency and nocturia‐related bother using nonparametric methods; statistically significant differences between groups in each cohort were established. Results Nocturia frequency alone does not comprehensively reflect attributable bother. Five sleep variables (poor quality sleep, short time to first awakening to void, less than 7 hours of total sleep, primary sleep latency, and daytime sleepiness) and daily urinary urgency were significantly associated with high nocturia‐related bother. Attributable bother, despite high‐frequency nocturia, was minimized by male gender, lack of daily urinary urgency and good sleep quality. Poor health status, urinary urgency and sleep latency were associated with nocturia frequency. Conclusions Items of importance to individuals with nocturia have been identified from patient data. These variables have the potential to sit alongside change in nocturia frequency as potential markers of treatment response.

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Linkage of Lower Urinary Tract Symptoms to Sleep Quality in Elderly Men with Nocturia: A Community Based Study Using Home Measured Electroencephalogram Data

Cited by 17 publications

References 17 publications

Does successful treatment of overactive bladder improve co‐morbidities in patients with nocturia?

Does successful treatment of overactive bladder improve co‐morbidities in patients with nocturia?

Rationale, design, and methods of electroencephalography-based investigation of the effects of oral desmopressin on improving slow-wave sleep time in nocturnal polyuria patients (the DISTINCT study): protocol for a single-arm, open-label, single-assignment trial

Nocturnal voiding frequency does not describe nocturia‐related bother

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