Linkage disequilibrium ofMHC genes in the chicken

Simonsen, Morten; Hála, K; Nicolaisen, Else Marie

doi:10.1007/bf01561559

Cited by 44 publications

(10 citation statements)

References 14 publications

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“…In other words, CC chickens carrying a "complete" B 4 haplotype are not able to respond well to "strong" challenge with transforming virus, but are able to control tumorigenic activity of the integrated v-src oncogene in the absence of production of viral particles by the transformed cells and subsequent reinfection and transformation of new cells, as is the case with RSV challenge. In CC.R1 chickens that carry a recombinant B haplotype, comprised of the B-F/L and B-G regions originating from different haplotypes which are not naturally associated (Simonsen et al 1980), we note a further drop in their resistance to tumorigenesis caused by the v-src oncogene. The precise mechanism and the type of histocompatibility antigens involved in regulation of the immune response in chickens (birds) are not fully understood.…”

Section: Discussionmentioning

confidence: 99%

Tumor induction by the LTR, v-src, LTR DNA in four B (MHC) congenic lines of chickens

et al. 1992

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We report that the cloned DNA harboring the long terminal repeat (LTR), v-src, LTR proviral structure is tumorigenic in chickens of the Prague congenic lines. The growth rate of these tumors is by far the highest in the recombinant CC.R1 line, the B haplotype of which is composed of the B-F/L4 and B-G12 subregions originating from different naturally occurring haplotypes. Some of the tumors induced by the LTR, v-src, LTR DNA are repeatedly transplantable in syngeneic chickens, maintain unaltered provirus, and express v-src mRNA. Differences in the response to challenge with Rous sarcoma virus (RSV) and LTR, v-src, LTR DNA on a given experimental model are compared and possible involvement of an interaction between B-F/L and B-G region genes is considered. Regression of the LTR, v-src, LTR DNA-induced tumors did not prevent the formation and growth of tumors induced subsequently by RSV.

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Section: Discussionmentioning

confidence: 99%

Tumor induction by the LTR, v-src, LTR DNA in four B (MHC) congenic lines of chickens

et al. 1992

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“…It is not clear whether B-G polymorphism reflects selection based on some functional property of the molecule, or some genetic phenomenon or property of the DNA. Known B-G alleles are in close linkage disequilibrium with B-F/B-L haplotypes (Simonsen et al 1980), but we are not sure how much of this is due to the low level of recombination between the two regions (Skjodt et al 1985), and to founder effects. A second phenomenon is the "adjuvant effect", in which alloantibodies for erythrocyte surface antigens such as B-F are only elicited if the erythrocytes also differ in the B-G region (Shierman andMcBride 1967, H~ila et al 1981).…”

Section: Introductionmentioning

confidence: 97%

B-G cDNA clones have multiple small repeats and hybridize to both chicken MHC regions

Kaufman¹,

Salomonsen

Skjødt

1989

Immunogenetics

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We used rabbit antisera to the chicken MHC erythrocyte molecule B-G and to the class I alpha chain (B-F) to screen lambda gt11 cDNA expression libraries made with RNA selected by oligo-dT from bone marrow cells of anemic B19 homozygous chickens. Eight clones were found to encode B-G molecules which hybridize with sequences in the chicken MHC as defined by congenic strains; the fusion proteins react with multiple immune but not preimmune sera, they select antibodies from the antisera to B-G, which then react with distinct erythrocyte B-G protein patterns, and they elicit antibodies from mice which in turn react with authentic B-G proteins. None of the clones represent a complete message, some--if not all--bear introns, and none of them match with any sequences presently stored in the data banks. The following new information did, however, emerge. At least two homologous transcripts are present in this homozygous chicken, thereby formally proving the existence of an expressed multigene family. The 3' ends (3'UT) are simple sequences with 80% nucleotide identity between clones, while the 5' ends (either coding or noncoding) are composed of multiple short repeats which are far less similar. These repeats could explain the bewildering variation in size of B-G proteins within and between haplotypes. Southern blots of genomic chicken DNA gave complex patterns for most probes, with many bands in common using different probes, but few bands in common between haplotypes. The sequences detected are all present in the MHC, based on the congenic lines CB and CC. Most of these sequences map into the B-G region, but some map into the B-F/B-L region as defined by the haplotypes B15, B21, and their apparently reciprocal recombinants B21r3 and B15r1.

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“…Alternatively, there may, by chance, be no hot spots of recombination within the chicken MHC (Crone and Simonsen, 1987). Either explanation would fit the quite unusually strong linkage disequilib rium between B-F and B-G which has been found by Simonsen et aL (1981).…”

Section: Genetic Structure Of the Chicken Mhcmentioning

confidence: 88%

Isolation and characterization of cDNA clones for chicken major histocompatibility complex class II molecules

et al. 1993

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Sung, Aree Moon, "Isolation and characterization of cDNA clones for chicken major histocompatibility complex class II molecules " (1989). Retrospective Theses and Dissertations. 9089. http://lib.dr.iastate.edu/rtd/9089 INFORMATION TO USERSThe most advanced technology has been used to photo graph and reproduce this manuscript from the microfilm master. UMI films the text directly from the original or copy submitted. Thus, some thesis and dissertation copies are in typewriter face, while others may be from any type of computer printer.The quality of this reproduction is dependent upon the quality of the copy submitted. Broken or indistinct print, colored or poor quality illustrations and photographs, print bleedthrough, substandard margins, and improper alignment can adversely affect reproduction.In the unlikely event that the author did not send UMI a complete manuscript and there are missing pages, these will be noted. Also, if unauthorized copyright material had to be removed, a note will indicate the deletion.Oversize materials (e.g., maps, drawings, charts) are re produced by sectioning the original, beginning at the upper left-hand comer and continuing from left to right in equal sections with small overlaps. Each original is also photographed in one exposure and is included in reduced form at the back of the book. These are also available as one exposure on a standard 35mm slide or as a 17" x 23" black and white photographic print for an additional charge.

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Linkage disequilibrium ofMHC genes in the chicken

Cited by 44 publications

References 14 publications

Tumor induction by the LTR, v-src, LTR DNA in four B (MHC) congenic lines of chickens

Tumor induction by the LTR, v-src, LTR DNA in four B (MHC) congenic lines of chickens

B-G cDNA clones have multiple small repeats and hybridize to both chicken MHC regions

Isolation and characterization of cDNA clones for chicken major histocompatibility complex class II molecules

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