Linkage disequilibrium between HLA‐G*0104 and HLA‐E*0103 alleles in Tswa Pygmies

Julie, D. C.; Bühler, Stéphane; Frassati, Coralie; Basire, Agnès; Galicher, Vital; Baier, Christian; Essautier, A.; Regnier, Adeline; Granier, Thomas; Lepfoundzou, A. D.; Chiaroni, Jacques; Picard, Christophe

doi:10.1111/j.1399-0039.2010.01599.x

Cited by 23 publications

(17 citation statements)

References 43 publications

(60 reference statements)

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“…We expected to find these results as UTR-5 is associated with HLA-G*01:03 and our team previously showed that the frequency of this allele greatly varies according to location, i.e. from 1.6% in southeast France to 9% in Congo-Brazzaville [48]. Based on these findings, we had speculated that UTR-5 frequency would be higher in sub-Saharan populations.…”

Section: Discussionmentioning

confidence: 65%

“…We showed in a previous study that there is not significant LD between HLA-G and HLA-E in Southeastern French and Teke Congolese, while two haplotypes in Tswa Pygmies, i.e. HLA-G*01:04∼E*01:03:01 and G*01:04∼E*01:01, exhibited highly significant positive and negative LD values respectively [48].…”

Section: Discussionmentioning

confidence: 69%

“…HLA-G*01:04 has been reported with moderate to high frequencies in several sub-Saharan African populations, i.e. Zambians, Ghanaians, Pygmies and Congolese [48], [49], [61]. HLA-A*23 and HLA-A*24 are associated with a large-scale deletion of 50 kb including the region that precedes HLA-G [34], [38], [39], [40].…”

Section: Discussionmentioning

confidence: 99%

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HLA-G UTR Haplotype Conservation in the Malian Population: Association with Soluble HLA-G

et al. 2013

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The HLA-G molecule plays an important role in immunomodulation. In a previous study carried out on a southern French population our team showed that HLA-G haplotypes, defined by SNPs in the coding region and specific SNPs located in 5′URR and 3′UTR regulatory regions, are associated with differential soluble HLA-G expression (sHLA-G). Furthermore, the structure of these HLA-G haplotypes appears to be conserved in geographically distant populations.The aim of our study is to confirm these expectations in a sub-Saharan African population and to explore additional factors, such as HLA-A alleles, that might influence sHLA-G expression.DNA and plasma samples were collected from 229 Malians; HLA-G and HLA-A genotyping were respectively performed by the Snap Shot® method and by Luminex™ technology. sHLA-G dosage was performed using an ELISA kit. HLA-G and HLA-A allelic and haplotypic frequencies were estimated using an EM algorithm from the Gene[Rate] program. Associations between genetic and non genetic parameters with sHLA-G were performed using a non-parametric test with GRAPH PAD Prism 5.Our results reveal a good conservation of the HLA-G UTR haplotype structure in populations with different origins and demographic histories. These UTR haplotypes appear to be involved in different sHLA-G expression patterns. Specifically, the UTR-2 haplotype was associated with low sHLA-G levels, displaying a dominant negative effect. Furthermore, an allelic effect of both HLA-G and HLA-A, as well as non genetic parameters, such as age and gender possibly linked to osteogenesis and sexual hormones, also seem to be involved in the modulation of sHLA-G.These data suggest that further investigation in larger cohorts and in populations from various ethnical backgrounds is necessary not only to detect new functional polymorphism in HLA-G regulatory regions, but also to reveal the extent of biological phenomena that influence sHLA-G secretion and this might therefore have an impact on transplantation practice.

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Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 69%

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HLA-G UTR Haplotype Conservation in the Malian Population: Association with Soluble HLA-G

et al. 2013

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“…Few data exist concerning the associations between HLA class Ib alleles; all located within a region of 724 kb on chromosome 6 ( Table 1 ) [ 50 – 52 ]. So far, the studies on HLA-E reported no LD with other HLA class Ib loci [ 35 ], except with HLA-G in isolated populations [ 53 ]. However, some HLA-E and HLA-A alleles have been described as being fully associated, e.g.…”

Section: Introductionmentioning

confidence: 99%

Association of HLA-A and Non-Classical HLA Class I Alleles

et al. 2016

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The HLA-A locus is surrounded by HLA class Ib genes: HLA-E, HLA-H, HLA-G and HLA-F. HLA class Ib molecules are involved in immuno-modulation with a central role for HLA-G and HLA-E, an emerging role for HLA-F and a yet unknown function for HLA-H. Thus, the principal objective of this study was to describe the main allelic associations between HLA-A and HLA-H, -G, -F and -E. Therefore, HLA-A, -E, -G, -H and -F coding polymorphisms, as well as HLA-G UnTranslated Region haplotypes (referred to as HLA-G UTRs), were explored in 191 voluntary blood donors. Allelic frequencies, Global Linkage Disequilibrium (GLD), Linkage Disequilibrium (LD) for specific pairs of alleles and two-loci haplotype frequencies were estimated. We showed that HLA-A, HLA-H, HLA-F, HLA-G and HLA-G UTRs were all in highly significant pairwise GLD, in contrast to HLA-E. Moreover, HLA-A displayed restricted associations with HLA-G UTR and HLA-H. We also confirmed several associations that were previously found to have a negative impact on transplantation outcome. In summary, our results suggest complex functional and clinical implications of the HLA-A genetic region.

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“…See materials and Methods section for specific subjects origin, since not all of them come from Andean area. Brazilians [41], Uros [44], Mayans [44], North Indians [57], Iranians [58], Iraqi [59], Danish [48], Spanish [23], Germans [60], French [61], Polish [62], Han Chinese [63], Koreans [46], Ghanaian [64], African American [64], Pygmies [61], Shona [47].…”

Section: Hla-g*01:05n In Amerindians: Comparison With Worldwide Populmentioning

confidence: 99%

HLA-G in Amerindians: Epidemiology and Worldwide Population Comparison

Arnaiz‐Villena¹,

Enríquez-de-Salamanca²,

Palacio-Grüber³

et al. 2018

MEDJ

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Background: HLA-G molecules are immunosuppressive and avoid fetal rejection by giving negative signals to maternal immune system from fetal trophoblast cell surface. HLA-G genes have been associated to different pathologies: Spontaneous abortions, autoimmunity, tumor progression, transplant rejection and infection. In addition, different World populations show remarkable different HLA-G allele frequencies in the allele that does not produce a full HLA-G molecule (HLA-G*05N); this allele is almost absent in studied Amerindians. Objectives: The aim is to study HLA-A.-B,-DRB1 and –G alleles and extended haplotypes in Amerindians for the first time. This may be useful to asses HLA-G epidemiology, association to disease and Preventive Medicine in Amerindians. Methods: HLA-A,-B and -DRB1 have been typed by using standard automatic protocols. HLA-G alleles have been detected by direct HLA-G exon 2, exon 3 and exon 4 DNA sequencing. Computer calculations have been done by specific standard methods. Results: HLA-A,-B,-DRB1 and –G extended haplotypes have been calculated in Amerindians for the first time. Also, their HLA-G frequencies have been compared with worldwide populations. Conclusion: Low frequencies of null HLA-G*01:05N allele are found in Amerindians. The extended haplotypes with this allele bear other typical Amerindian HLA-DRB1 alleles and its origin is discussed. HLA-G allele frequency profile is closer to that of Europeans than to that of Far East Asians. Our findings are useful to Preventive Medicine and Epidemiology associated to Fertility and HLA-G associated pathology and transplantation.

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Linkage disequilibrium between HLA‐G0104 and HLA‐E0103 alleles in Tswa Pygmies

Cited by 23 publications

References 43 publications

HLA-G UTR Haplotype Conservation in the Malian Population: Association with Soluble HLA-G

HLA-G UTR Haplotype Conservation in the Malian Population: Association with Soluble HLA-G

Association of HLA-A and Non-Classical HLA Class I Alleles

HLA-G in Amerindians: Epidemiology and Worldwide Population Comparison

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