“…The implementation of learning health systems (LHSs) is an area of strong interest for healthcare organizations, policymakers, and the public. 1 , 2 , 3 To date, however, many LHS efforts have been developed within single organizations, 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 not as collaborations among separate entities. Given the need to develop collaborative LHSs that are healthcare market‐centric, as opposed to organization‐centric, two questions are particularly relevant: (a) What are promising approaches to operationalizing an LHS across a regional healthcare market that spans different organizations?…”