Linkage Between a Muscle-Specific Creatine Kinase Gene Polymorphism and Vo2max Trainability in the Heritage Family Study

Rivera, Miguel A.; russe, L. P; Gagnon, Jocelyn; Simoneau, J-A.; Dionne, F. T.; Leon, A. S.; Skinner, Jeffrey S.; Wilmore, Jack H.; Rao, D. C.; Bouchard, C.

doi:10.1097/00005768-199805001-00037

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“…However, in several investigations in endurance-based sports, where aerobic energy systems lead energy production, the distribution of the AA genotype and the A allele is more frequent in elite athletes 4 10 . It has also been found that the A allele can even affect the increase in aerobic power induced by endurance training 11 . The different role of the CKM rs8111989 across sports may be due to the higher relevance of creatine kinase to ensure ATP flux in all-out exercise activities such as sprinting and jumping 4 .…”

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confidence: 99%

Association of the CKM rs8111989 Polymorphism with Injury Epidemiology in Football Players

et al. 2022

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The influence of the rs8111989 polymorphism in the muscle-specific creatine kinase gene (CKM) on injury incidence is unknown. The aim was to investigate CKM polymorphism on injury incidence in high-performance football players. A cohort of 109 high-performance players was genotyped by using saliva samples. Injury incidence was similar in players with the GG, GA, and AA genotypes and did not modify incidence during training or match exposure (p=0.583 and p=0.737 respectively). GG players had a higher frequency of slight-severity injuries (60.0 vs. 10.2 vs. 24.2%, p<0.001), while GA players had a higher frequency of severe injuries (16.7 vs. 30.8 vs. 10.0%, p=0.021). GA players also had a higher frequency of muscle tears (34.8 vs. 59.0 vs. 20.0%, p<0.001). Muscle contracture was a more frequent injury in players with the GG genotype (40.0%, p<0.001). G allele carriers had lower frequencies of gradual-onset injuries (4.1 vs. 16.7%, p=0.035) and recurrent injuries (6.1 vs. 16.7%, p=0.003) than AA players. A allele carriers had higher frequency of severe injuries (10.0 vs. 21.9%, p=0.044) than GG players. Genotypes in the CKM rs8111989 polymorphism did not affect injury incidence in high-performance football players. Players with the GA genotype were more prone to severe injuries and muscle tears when compared to GG and AA players.

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Section: Introductionmentioning

confidence: 99%

Association of the CKM rs8111989 Polymorphism with Injury Epidemiology in Football Players

et al. 2022

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“…Furthermore, using the sib-pair linkage approach, a weak suggestive evidence for genetic linkage between the CKMM locus and the covariate (age, sex, body mass, and pre-training VO 2max ) adjusted VO 2max (ml • min -1 ) was also observed (26). However, using the GENEATHLETE cohort, the CKMM marker did not contribute to the proper classification of Caucasian males into elite endurance athletes or sedentary controls (25).…”

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Polymorphism and exercise performance

Wolfarth

2001

European Journal of Sport Science

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The fields of molecular genetics and molecular biology are of increasing interest in medicine and science. The aim of this article is to describe the current status of genetics in sports, with a special focus on genetic polymorphisms and endurance performance. Results from twin studies suggested a high percentage of heritability for endurance performance and maximal oxygen uptake (VO 2max ). Data from large sample sizes of monozygotic and dizygotic twins showed heritability values up to 40% for adjusted VO 2max values. Today we are able to use molecular markers to look for specific genes and their implications for phenotypes of interest. The first results for endurance-related phenotypes are available now. Till now we have evidence for association between different types of endurance measures and polymorphisms in the genes encoding the Angiotensin-Converting-Enzyme (ACE), the muscle type Creatine-Kinase (CKMM), and the alpha-2a-adrenoceptor (ADRA2A) gene. The scientific focus in the next years will mainly involve case-control studies and genome analysis with informative markers in known and unknown genes (regions) of interest.

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Linkage Between a Muscle-Specific Creatine Kinase Gene Polymorphism and Vo2max Trainability in the Heritage Family Study

Cited by 2 publications

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Association of the CKM rs8111989 Polymorphism with Injury Epidemiology in Football Players

Association of the CKM rs8111989 Polymorphism with Injury Epidemiology in Football Players

Polymorphism and exercise performance

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