Linkage between a muscle-specific CK gene marker and &amp;OV0312;O2max in the HERITAGE Family Study

Ma, Rogawski; Pérusse, Louis; Simoneau, J-A.; Gagnon, Jacques; Ft, Dionne; Leon, AS; Js, Skinner; Jh, Wilmore; Province, Michael A.; Dc, Rao; Bouchard, Claude

doi:10.1097/00005768-199905000-00012

Cited by 60 publications

(43 citation statements)

References 9 publications

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“…Recently interdependence between the CK-MM A/G polymorphism and individual differences in the expression of the physical qualities of a person has been shown in several studies (17,18). Association of the CK-MM A/G polymorphism with the increment in aerobic power after aerobic physical training of subjects not engaged in sports has been demonstrated (13,16,19).…”

Section: Introductionmentioning

confidence: 97%

“…It is believed that the A/G polymorphism is also associated with different CK-MM activities in myocytes (13). The frequency of the minor G allele in this type of polymorphism varies in the range from 15% in the Chinese population to 29% -35% in Caucasians and 32% in white Americans (14)(15)(16). Recently interdependence between the CK-MM A/G polymorphism and individual differences in the expression of the physical qualities of a person has been shown in several studies (17,18).…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Muscle-Specific Creatine Kinase (CK-MM) Gene Polymorphism (rs8111989) Among Professional, Amateur Athletes and Non-athlete Karatekas

et al. 2017

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Background: Identification of genetic markers is one of the priority trends to perform in athletes for evaluation of their efficacy. Previous studies have revealed that CK-MM may be used as a valuable marker to reflect the magnitude of skeletal muscle destruction in response to exercise. Objectives: In this study we analyzed the frequency of rs8111989CK-MM polymorphism in karatekas to find whether there is a difference among professional, amateur athletes and non-karatekas. Methods: Distribution of allele and genotype frequencies of the muscle specific creatine kinase (CK-MM) gene A/G polymorphism was assessed in a survey among 275 athletes residing in state of Isfahan (86 professional karatekas (43 male and 43 female) and 86 amateur karatekas (50 male and 36 female) and 103 non-athlete individuals (50 male and 53 female). Blood samples were taken and genotyping was performed by restriction fragment length polymorphism (RFLP) approach. Statistical analyses carried out using SPSS software and data with P < 0.05 were considered to be significant. Results: The CK-MM AG genotype frequency was significantly higher in professional and amateur karate athletes and control sub-

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Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Comparison of Muscle-Specific Creatine Kinase (CK-MM) Gene Polymorphism (rs8111989) Among Professional, Amateur Athletes and Non-athlete Karatekas

et al. 2017

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“…Although numerous studies have reported a relationship between these two items [9][10][11][12][13][14], it remains controversial. Furthermore, mitochondrial DNA (mtDNA) [15,16], the creatine kinase gene [17][18][19] and the Na ϩ -K ϩ -ATPase ∂2 gene [20] have been studied as genes that may dictate individual differences in endurance capacity or trainability. mtDNA is a double-stranded, circular molecule of 16,569 bp within the mitochondria [21] and has many more polymorphisms than seen in nuclear DNA [22].…”

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confidence: 99%

Polymorphisms in Control Region of mtDNA Relates to Individual Differences in Endurance Capacity or Trainability.

Murakami

Ota²,

Simojo³

et al. 2002

JJP

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“…A polymorphism in the CK-M gene was detected by chain polymerase reaction and DNA digestion with the endonuclease enzyme of NcoI restriction. The allele with site susceptible to digestion for NcoI was designated as 985+185 pb allele, while the allele without the site for NcoI restriction was designated as 1170 pb allele (69) . This variable defined as NcoI is located in the region 3' of the gene (70) .…”

Section: +185/1170 Polymorphism Of the Creatine Kinase M Enzyme Gementioning

confidence: 99%

Polimorfismos genéticos determinantes da performance física em atletas de elite

Dias

Pereira²,

Negräo³

2007

Rev Bras Med Esporte

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Este artigo direciona-se à revisão de publicações sobre os "genes candidatos" e sua relação com os fenótipos de performance física humana em atletas de elite. Nosso objetivo é trazer ao conhecimento do leitor informações atualizadas sobre marcadores e variantes genéticas que podem levar certos indivíduos a sobressair-se em modalidades esportivas específicas. Além disso, serão descritos os mecanismos pelos quais um gene pode contribuir para a performance física, detalhando em cada momento as propriedades celulares, fisiológicas e moleculares do sistema em questão. Por esse motivo, limitamos nossa discussão a um número pequeno de variantes genéticas: polimorfismos R577X do gene da alfa-actinina 3 (ACTN3), C34T do gene da AMP deaminase (AMPD1), I/D da enzima conversora de angiotensina (ECA), -9/+9 do receptor beta2 de bradicinina (BDKRB2) e 985+185/1170 do gene da enzima creatina quinase M (CK-M). Esperamos com este artigo informar e sensibilizar o leitor para o fato de que a identificação de talentos e a otimização do potencial individual do atleta, com conseqüente sucesso no esporte, estão diretamente associados a variantes genéticas.

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Linkage between a muscle-specific CK gene marker and &OV0312;O2max in the HERITAGE Family Study

Abstract: The present results provide further support for the notion that the CKMM gene, or some gene in close linkage disequilibrium with it, may contribute to individual differences in the VO2max response to endurance training.

Cited by 60 publications

References 9 publications

Comparison of Muscle-Specific Creatine Kinase (CK-MM) Gene Polymorphism (rs8111989) Among Professional, Amateur Athletes and Non-athlete Karatekas

Comparison of Muscle-Specific Creatine Kinase (CK-MM) Gene Polymorphism (rs8111989) Among Professional, Amateur Athletes and Non-athlete Karatekas

Polymorphisms in Control Region of mtDNA Relates to Individual Differences in Endurance Capacity or Trainability.

Polimorfismos genéticos determinantes da performance física em atletas de elite

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