Linkage Analysis in Man

Conneally, P. M.; Rivas, Marian L.

doi:10.1007/978-1-4615-8288-5_3

Cited by 29 publications

(17 citation statements)

References 68 publications

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“…of 1-69 was generated. Even though this score did not reach the generally accepted value of 3-0 for statistical significance, it is strongly suggestive of linkage of marker phenotype and main locus in view of the very generous allowance for Type 11 error made in the original calculation of the limits for sequential analysis (20). Indeed, a score or 1 -69 indicates that linkage between HLA and LMAT response is 50 times more likely than not.…”

Section: Linkage Analysis Of Hla Markersmentioning

confidence: 77%

Leprosy and immunity: genetics and immune function in multiple case families

Rawlinson

Basten

et al. 1988

Immunol Cell Biol

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Summary. Genetic susceptibility to infection with M. leprae was studied in 10 multiple case families of Australian Aborigines. Of the 87 members available for study, 24 had proven stable clinical leprosy which had been or was still being treated with diamino diphenyl sulphone. Evidence of contact with M. leprae in the remaining 63 members as assessed by ELISA to M. leprae sonicate and phenolic glycolipid (PGL) or by indirect immunofluorescence antibody assay was found in 78%, 64% and 71%, respectively. By contrast, in vilro assays of T cell function (LMAT and LTT) were less reliable indicators of exposure.Evidence was sought for possible linkages between human leucocyte antigen (HLA) or non-HLA genes and four marker phenotypes including clinical leprosy, clinical subtype of leprosy and lymphocyte transformation or leucocyte migration inhibition factor (LIF) production in response to M. leprae antigen. No associations were found with any particular HLA or non-HLA gene. On the other hand, sequential analysis of the data from the 10 families was strongly suggestive of a linkage between HLA haplotype and non-responsiveness to M leprae as manifest by lack of LIF production but not lymphocyte transformation.The model which best fits the data is for a gene on chromosome 6 in close linkage with the HLA haplotype, with two alleles, autosomal recessive inheritance and penetrance of 90%. On this basis, it can be suggested that disease type (lepromatous leprosy) rather than disease susceptibility may be controlled by genes within or closely linked to the major histocompatibility gene complex.

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Section: Linkage Analysis Of Hla Markersmentioning

confidence: 77%

Leprosy and immunity: genetics and immune function in multiple case families

Rawlinson

Basten

et al. 1988

Immunol Cell Biol

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“…however, to observations made in other organisms as different as man and fish that presently known marker loci are not randomly distributed among the chromosomes. Of 35 autosomal marker loci assigned to chromosomes in man, 10 are known to be on chromosome I , 8 on chromosome 6, and 4 on chromosome 9 (see CONNEALLY and RIVAS 1980). In the fish genus Poeciliopsis 5 of IS biochemical loci studied are in one linkage group (LESLIE 1982).…”

Section: Discussionmentioning

confidence: 99%

Genetic linkage in the horse

Sandberg

Andersson

2008

Hereditas

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Sandberg, K. and Andersson, L. 1984. Genetic linkage in the horse. I. Linkage relationships among 15 blood marker loci.—Hereditas 100: 199–208. Lund, Sweden. ISSN 0018–0661. Received June 27, 1983 Comprehensive data on linkage relationships among the six equine blood group loci A, C, D, K, P, and Q. and the structural loci controlling the three serum proteins albumin (Al), esterase (Es), transferrin (Tf), the six red cell proteins acid phosphatase (AP), carbonic anhydrase (CA), hemoglobin (Hb). 6–phosphogluconate dehydrogenase (PGD), phosphoglucomutase (PGM), and phosphohexose isomerase (PHI), and sex are reported. The study is based on the examination of paternal half‐sib groups. Evidence is presented that the serum esterase locus is linked to the serum albumin locus and thus belongs to the equine linkage group (LG) II. Additional data on the previously described linkage between K and PGD are reported. The male recombination fraction of the Al:Es linkage was estimated at 0.366±0.007 and of the K:PGD linkage at 0.258±0.008. Significant heterogeneity of recombination fractions among sires was observed for the K:PGD linkage. The results of the present study were compared with linkage information from other vertebrate species, in view of the concept of linkage homology. The fact that equine LG II comprises no less than seven loci, although only about 25 autosomal loci altogether have been subjected to linkage studies in the horse, was discussed in the light of similar observations made in other species.

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“…Various mapping functions have been proposed, many of which include a measure of inhibition (positive interference) or enhancement (negative interference) of formation of other cross-overs in the region of interest that may result from occurrence of an original cross-over. For more complete discussion of mapping functions, see Ott (1992) or Conneally and Rivas (1980).…”

Section: Genetic Mapmentioning

confidence: 99%

“…The algorithm makes possible inclusion of information on all individuals in an extended family in a linkage analysis, not just sibship data. A hand-calculated example of the application of the algorithm to a small pedigree is given in Conneally and Rivas (1980).…”

Section: Calculation Of Lod Scoresmentioning

confidence: 99%

Analysis of Genetic Linkage Data for Mendelian Traits

Pericak‐Vance

1996

CP Human Genetics

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This unit describes linkage analysis, an invaluable tool in mapping human disease genes. Linkage analysis is one of several methods used to map genes. Specifically, in linkage analysis cosegregation of two or more genes (traits) is examined in a family unit to determine if they segregate independently according to Mendel's laws or if they do not segregate independently because of their close physical proximity. The procedures outlined in this unit are not always straightforward, and a number of caveats are presented in the commentary regarding possible complications and confounding factors that may arise. Specific examples are given, but it is not possible to cover all possible scenarios or variables. The intention is to enable the reader to master basic principles used in the linkage approach and thus be in a position to undertake, with proper consultation, a linkage-analysis study. This unit deals specifically with lod score analysis in Mendelian disorders.

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Linkage Analysis in Man

Cited by 29 publications

References 68 publications

Leprosy and immunity: genetics and immune function in multiple case families

Leprosy and immunity: genetics and immune function in multiple case families

Genetic linkage in the horse

Analysis of Genetic Linkage Data for Mendelian Traits

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