Link-Polymorphism of 5-HTT Promoter Region Is Associated with Autoantibodies in Patients with Systemic Lupus Erythematosus

Li, Shu; Liu, Shuang; Fan, Chen; Cheng, Yuqi; Bai, Ru; Lai, Aiyun; Lü, Zhaoping; Xu, Jian

doi:10.1155/2016/3042726

Cited by 4 publications

(4 citation statements)

References 28 publications

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“…In our study, there were no significant differences observed in the genotype and allele frequency of 5-HTTLPR between the SLE and HC groups. This aligns with the research findings reported by Li et al [ 18 ]. This suggests that there isn't a direct association between genetic variations in 5-HTTLPR and susceptibility to SLE.…”

Section: Discussionsupporting

confidence: 93%

Interaction of 5-HTTLPR and SLE disease status on resting-state brain function

Ma,

Yang,

et al. 2024

Arthritis Res Ther

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Background Neuropsychiatric involvement in systemic lupus erythematosus (SLE) is a common clinical manifestation. In SLE patients, cerebral function is a more sensitive predictor of central nervous system damage, and abnormalities in cerebral function may be apparent before substantial neuropsychiatric symptoms occur. The 5-hydroxynyptamine(5-HT) system has the ability to interact with the majority of the neurochemical systems in the central nervous system (CNS), influencing brain function. Serotonin transporter gene-linked polymorphic region (5-HTTLPR) is an essential element of the 5-HT system gene polymorphism and is directly related to the control of 5-hydroxytryptamine transporter (5-HTT)gene expression. The relationship between 5-HTTLPR and functional brain measurements in SLE patients requires more investigation because it is one of the most attractive imaging genetics targets for shedding light on the pathophysiology of neuropsychiatric lupus. Methods Resting-state functional magnetic resonance imaging (rs-fMRI) images were collected from 51 SLE patients without obvious neuropsychiatric manifestations and 44 healthy volunteers. Regional homogeneity (ReHo), amplitude of low-frequency fluctuations (ALFF), and fractional amplitude of low-frequency fluctuations (fALFF) were selected as indicators for evaluating brain function. In accordance with the Anatomical Automatic Labeling template, the gray matter was divided into 116 regions. The mean ReHo value, mean ALFF value, and mean fALFF value of each brain region were extracted. 5-HTTLPR genotypes of all research objects were tested by polymerase chain reaction and agarose gel electrophoresis. Two-way analysis of covariance was used to investigate whether there is an interaction effect between SLE disease status and 5-HTTLPR genotype on resting-state brain function. Results In SLE patients with S/S homozygosity, there were notably lower mean ReHo, mean ALFF, and mean fALFF values observed in the right parietal, inferior angular gyrus, and the right paracentral lobule compared to healthy controls. However, this distinction was not evident among carriers of the L allele. Within the S/S genotype, SLE patients exhibited decreased mean ReHo in the left posterior cingulate gyrus, reduced mean fALFF in the left caudate nucleus, and diminished mean ALFF in the left temporal pole: superior temporal gyrus, in contrast to the HC group. Conversely, no such differences were discerned among carriers of the L allele. Notably, among L allele carriers, SLE patients displayed a higher mean ReHo value in the right hippocampus compared to the HC group, while demonstrating a lower mean ALFF value in the left medial and paracingulate gyrus in contrast to the HC group. Conversely, these differences were not apparent among S/S homozygotes. Conclusions Brain function in the right parietal and inferior angular gyrus and the right paracentral lobule is affected by the interaction effect of SLE disease status and 5-HTTLPR genotype.

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Section: Discussionsupporting

confidence: 93%

Interaction of 5-HTTLPR and SLE disease status on resting-state brain function

Ma,

Yang,

et al. 2024

Arthritis Res Ther

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“…Involvement of such genes as interferon-regulating factor 5 (T-receptors' signals), gene encoding protein 1, rich in H-leucine, which is repeated (gene for N-leucine-rich-repeat protein -NALP1), interferoninduced helicase C domain 1 gene -1990760 (interferoninduced helicase 1 rs1990760 -IFIH1 rs1990760), N-acetyltransferase 2 gene (N-acetyltransferase 2 -NAT2) was also confirmed. Interferon is thought to be important in the pathogenesis of SLE as well [73,76,79,80,121,126].…”

Section: Methodsmentioning

confidence: 99%

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2021

Lʹviv. klin. visn.

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Оригінальні дослідженняdrug treatment in patients of the control group there was a significant clinical and functional improvement, though sinus tachycardia, ventricular extrasystole of high grades and supraventricular extrasystole remained resistant to treatment. There was also a pronounced endothelial vascular dysfunction, which in the process of standard treatment in patients of the control group did not reach the level of healthy individuals (p < 0.05).Conclusions. In patients with acute MI with comorbid MS, who underwent balloon angioplasty and stenting of the infarct-dependent coronary artery, a pronounced vascular endothelial dysfunction and electrical instability is observed, accompanied by reperfusion arrhythmias and arrhythmias. The use of arginine-carnitine mixture as upstream therapy helped to restore endothelial function and showed a pronounced antiarrhythmic effect, which significantly reduced the incidence and severity of complications of acute MI such as reperfusion arrhythmias.

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“… 15 This polymorphism has been studied in few other conditions such as irritable bowel syndrome (IBS), 16 pain severity in idiopathic trigeminal neuralgia patients, 17 and systemic lupus erythematosus. 18 However, there is no study to report the association between SERT gene polymorphism and gut motility as well as the occurrence of various GI symptoms in T2DM patients. Therefore, this study would deal with these aspects of SERT gene polymorphism in T2DM individuals.…”

Section: Introductionmentioning

confidence: 99%

Impact of serotonin transporter gene polymorphism on gut motility in patients with type 2 Diabetes mellitus

Malik

Saha

Morya

et al. 2021

J Neurogastroenterol Motil

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Background/Aims The pathogenesis of gastrointestinal (GI) symptoms in patients with type 2 diabetes mellitus (T2DM) is yet to be delineated clearly. Serotonin, a monoamine neurotransmitter, resides primarily in the gut and plays a vital role in GI system. However, no study has been documented the role of serotonin and serotonin transporter gene (SLC6A4) polymorphism in the development of GI symptoms in T2DM patients. Methods Three hundred diabetes patients attending diabetes clinic at Postgraduate Institute of Medical Education and Research, Chandigarh, and matched healthy controls were enrolled for this study. Plasma from collected blood sample was used for serotonin measurement by enzyme-linked immunosorbent assay method and buffy coat was used for isolation of DNA by phenol chloroform method. Serotonin transporter gene polymorphism was analyzed by polymerase chain reaction method. Results The frequency of short allele (S) and SS genotype was significantly higher in patients with T2DM than controls and was associated with increased risk of T2DM. The frequency of LS genotype showed an association with protection from the disease. Regarding GI symptoms, 78.2% of patients with constipation showed LL and LS genotypes, and 97.7% of patients with diarrhea had SS genotype. The patients without GI symptoms did not show any association of gut motility with genotype. Furthermore, serotonin was significantly higher in diabetic patients who belonged to SS genotype compared to LS or LL genotype and who presented with diarrhea. Conclusion SS genotypes are prone to develop diarrhea because of faster gut motility resulting from higher serotonin levels as compared to LS and LL genotype in T2DM patients.

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Link-Polymorphism of 5-HTT Promoter Region Is Associated with Autoantibodies in Patients with Systemic Lupus Erythematosus

Cited by 4 publications

References 28 publications

Interaction of 5-HTTLPR and SLE disease status on resting-state brain function

Interaction of 5-HTTLPR and SLE disease status on resting-state brain function

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Impact of serotonin transporter gene polymorphism on gut motility in patients with type 2 Diabetes mellitus

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