Link between temperament traits, brain neurochemistry and response to SSRI: insights from animal model of social behavior

Murlanova, Kateryna; Michaelevski, Izhak; Kreinin, Anatoly; Terrillion, Chantelle E.; Pletnikov, Mikhail; Pinhasov, Albert

doi:10.1016/j.jad.2020.11.005

Cited by 18 publications

(24 citation statements)

References 52 publications

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“…The altered monoamine content in brain areas referring to emotionality and social hierarchy underly the behavioral phenotype in Sub and Dom mice. The decreased levels of 5-HT in the brainstem, reduced levels of norepinephrine in the prefrontal cortex and hippocampus, and elevated levels of dopamine in the prefrontal cortex, HPC, striatum and brainstem were measured in Sub mice [ 186 ].…”

Section: Models Of Depressionmentioning

confidence: 99%

Animal Models of Depression: What Can They Teach Us about the Human Disease?

2021

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Depression is apparently the most common psychiatric disease among the mood disorders affecting about 10% of the adult population. The etiology and pathogenesis of depression are still poorly understood. Hence, as for most human diseases, animal models can help us understand the pathogenesis of depression and, more importantly, may facilitate the search for therapy. In this review we first describe the more common tests used for the evaluation of depressive-like symptoms in rodents. Then we describe different models of depression and discuss their strengths and weaknesses. These models can be divided into several categories: genetic models, models induced by mental acute and chronic stressful situations caused by environmental manipulations (i.e., learned helplessness in rats/mice), models induced by changes in brain neuro-transmitters or by specific brain injuries and models induced by pharmacological tools. In spite of the fact that none of the models completely resembles human depression, most animal models are relevant since they mimic many of the features observed in the human situation and may serve as a powerful tool for the study of the etiology, pathogenesis and treatment of depression, especially since only few patients respond to acute treatment. Relevance increases by the fact that human depression also has different facets and many possible etiologies and therapies.

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Section: Models Of Depressionmentioning

confidence: 99%

Animal Models of Depression: What Can They Teach Us about the Human Disease?

2021

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“…PXT functions as a potent SERT inhibitor and reduces 5-HT reuptake, leading to a redistribution of 5-HT in favor of the synaptic cleft and a consequent decrease in presynaptic cytosolic concentrations. These events may trigger compensatory reduction of 5-HT degradation due to the disinhibition of the activity of tryptophan hydroxylase, reflected by decreased 5-HIAA content and increased 5-HT production 45 as demonstrated here by decreased 5-HIAA/5-HT ratio.…”

Section: Discussionmentioning

confidence: 57%

“…Submissive (Sub) mice used in this study were selectively bred for 36 generations from an outbred Sabra strain (Envigo laboratories, Israel) using social interaction dominant-submissive relationship paradigm 58 . The behavioral profile of Sub mice possesses strong elements of depressive-like behavior and impaired stress coping strategies confirmed by different experimental approaches 25 – 28 .…”

Section: Methodsmentioning

confidence: 94%

“…Prefrontal cortex (PFC) and hippocampus (HPC) were dissected, frozen in liquid nitrogen and kept at − 80 °C until use. Serotonin (5-hydroxytryptamine, 5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) were assayed in brain tissue samples using HPLC with electrochemical detection (EICOM Co., Kyoto, Japan) as previously described 45 .…”

Section: Methodsmentioning

confidence: 99%

“…The behavioral effect of D. viscosa extracts was examined in submissive (Sub) mice, previously validated as a mouse model of depressive-like behavior [26][27][28] . Initial screening of D. viscosa root extract revealed that single and sub-chronic (14 days, daily) 5 mg/kg i.p.…”

Section: Acute and Sub-chronic D Viscosa Root Extract Administration ...mentioning

confidence: 99%

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Antidepressant-like effects of a chlorogenic acid- and cynarine-enriched fraction from Dittrichia viscosa root extract

Murlanova

Cohen

Pinkus

et al. 2022

Sci Rep

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Dittrichia viscosa is a perennial Mediterranean plant used in traditional medicine for “calming purposes”, pointing at a possible antidepressant activity of the plant. We conducted chromatographic and bioassay-guided fractionation of D. viscosa root extract to isolate a specific fraction (fraction “K”) with antidepressant-like characteristics in vivo and strong antioxidant properties in vitro. A single dose of “K” reduced immobility time in the forced swim test with a mouse model possessing a depressive-like phenotype. Neurochemical profiling for 5-hydroxytryptamine (5-HT) and its primary metabolite, 5-hydroxyindoleacetic acid (5-HIAA), in prefrontal cortex and hippocampus of “K”-treated mice showed reduction in 5-HIAA, indicative of either serotonin uptake transporter or monoamine oxidase-A inhibition, as well as slight increases in 5-HT content. These neurochemical alterations, as well as the behavioral changes observed, were comparable to the effects of paroxetine. “K” also protected PC12 cells in a H2O2 cytotoxicity assay, thus demonstrating antioxidant properties, yet paroxetine augmented oxidative damage and cell death. Identification of the main compounds in “K” by high-performance liquid chromatography-tandem mass spectrometry (HPLC–MS/MS) indicated that chlorogenic acid and cynarine comprised 87% of the total components. D. viscosa root extract appears to produce antidepressant and cytoprotective effects and may serve as an attractive alternative to standard therapies for depression.

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Inherited stress resiliency prevents the development of metabolic alterations in diet‐induced obese mice

Ben‐Shachar

Daniel

Wollman

et al. 2023

Obesity

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Objective Chronic stress promotes obesity and metabolic comorbidities. The ability of individuals to cope with stress may serve as an important parameter in the development of obesity‐related metabolic outcomes. The aim of this study was to clarify whether differences in stress response affect metabolic health under obesity. Methods The study was performed in a selectively bred mouse model of social dominance (Dom) and submissiveness (Sub), which exhibit stress resilience or vulnerability, respectively. Mice were given a high‐fat diet (HFD) or standard diet, followed by physiological, histological, and molecular analyses. Results The HFD caused hyperleptinemia, glucose intolerance, insulin resistance, steatosis of the liver and pancreas, and brown adipose tissue whitening in Sub mice, whereas Dom mice were protected from these consequences of the HFD. The HFD increased circulating levels of interleukin (IL)‐1β and induced the expression of proinflammatory genes in the liver and in epididymal white adipose tissue of Sub mice, with no changes in Dom mice. The Cox2 inhibitor celecoxib (15 mg/kg/d) reduced serum IL‐1β, improved glucose tolerance and insulin sensitivity, and prevented hepatic and brown adipose tissue whitening in HFD‐fed Sub mice. Conclusions The extent of stress resiliency is associated with inflammation and contributes to population heterogeneity in the development of healthy or unhealthy obesity.

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Link between temperament traits, brain neurochemistry and response to SSRI: insights from animal model of social behavior

Cited by 18 publications

References 52 publications

Animal Models of Depression: What Can They Teach Us about the Human Disease?

Animal Models of Depression: What Can They Teach Us about the Human Disease?

Antidepressant-like effects of a chlorogenic acid- and cynarine-enriched fraction from Dittrichia viscosa root extract

Inherited stress resiliency prevents the development of metabolic alterations in diet‐induced obese mice

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