Link between sterile inflammation and cardiovascular diseases: Focus on cGAS-STING pathway in the pathogenesis and therapeutic prospect

Du, Yanming; Zhang, Hui; Nie, Xin; Qi, Yinghua; Shi, Shi; Han, Yingying; Zhou, Wenchen; He, Chaoyong; Wang, Lintao

doi:10.3389/fcvm.2022.965726

Cited by 8 publications

(3 citation statements)

References 126 publications

(194 reference statements)

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“…Sterile inflammation involved in the development of heart failure can triggered by mtDNA [ 48 ]. According to previous studies, this sterile inflammatory response contributes to cardiac dysfunction by promoting leukocyte infiltration, cytokine release, and oxidative stress [ 49 , 50 ]. Furthermore, mitochondrial ROS production during renal IR injury can directly damage cardiomyocytes by inducing oxidative stress and impairing mitochondrial function [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Does cardiac impairment develop in ischemic renal surgery in rats depending on the reperfusion time?

Prem,

Kurian

2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

Does cardiac impairment develop in ischemic renal surgery in rats depending on the reperfusion time?

Prem,

Kurian

2024

Heliyon

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“…The cGAS-STING pathway, triggered by DNA present in the cytoplasm, facilitates the activation of two key transcription factors, namely interferon regulatory factor 3 (IRF3) and nuclear factor-κB (NF-κB). This activation subsequently results in the elevation of inflammatory factors and interferons (IFNs) [ 26 ]. IKKβ/IKBKB, referred to as IκB kinase beta or IKK2, acquired its nomenclature due to its role in the phosphorylation of IκB molecules, which function as inhibitors of NF-κB transcription factors [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Molecular map of cGAS-STING pathway-related genes in bladder cancer: the perspective toward immune microenvironment and prognosis

Wei,

Liu,

Yuan

et al. 2024

Aging

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Background: The cGAS-STING pathway emerges as a pivotal innate immune pathway with the potential to profoundly influence all facets of tumor initiation and progression. The prognostic significance and immunological role of cGAS-STING pathway-related genes (CRGs) in individuals diagnosed with bladder cancer (BLCA) have not yet been fully elucidated. Methods: Performed unsupervised cluster analysis to identify distinct clusters. Utilizing LASSO and multivariate Cox regression analysis to construct a prognostic risk model. The IMvigor210, GSE13507 and GSE78220 cohorts were utilized to explore the potential value of risk score in immune therapy response and survival prediction. Results: A risk model was developed utilizing four CRGs in order to forecast the overall survival (OS) of BLCA patients. The risk score to be a standalone risk factor, which was further corroborated by the external validation set obtained from the GEO database (GSE13507). We established an integrated nomogram that combined risk scoring and clinical information, exhibiting commendable clinical practicality in predicting the overall survival period of BLCA patients. It is noteworthy that risk score could differentiate tumor microenvironments among different risk groups and individuals who were more responsive to immunotherapy in IMvigor210 and GSE13507 cohorts. In vitro experiments, we noted an up-regulation of IRF3 and IKBKB upon the activation of the cGAS-STING pathway. Conversely, the activation of the cGAS-STING pathway resulted in a down-regulation of POLR3G and CTNNB1. Conclusions: CRG risk model shows promise as a potential stratification approach for bladder cancer patients.

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“…Aseptic inflammation is the absence of microbial infection and features of intractable chronic inflammation that promote the development of autoimmune, metabolic, neurodegenerative, and cardiovascular diseases [ 86 ]. Inflammation requires either exogenous (e.g., microorganisms, bacteria, and viruses) or endogenous (e.g., autologous DNA, proteins, and lipids) ligands that activate downstream inflammatory signals [ 87 ].…”

Section: Risk Factors For Activating Cgas-sting In Daily Lifementioning

confidence: 99%

The cGAS-STING pathway in cardiovascular diseases: from basic research to clinical perspectives

An,

Li,

Chen

et al. 2024

Cell Biosci

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The cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase-stimulator of interferon genes (cGAS-STING) signaling pathway, an important component of the innate immune system, is involved in the development of several diseases. Ectopic DNA-induced inflammatory responses are involved in several pathological processes. Repeated damage to tissues and metabolic organelles releases a large number of damage-associated molecular patterns (mitochondrial DNA, nuclear DNA, and exogenous DNA). The DNA fragments released into the cytoplasm are sensed by the sensor cGAS to initiate immune responses through the bridging protein STING. Many recent studies have revealed a regulatory role of the cGAS-STING signaling pathway in cardiovascular diseases (CVDs) such as myocardial infarction, heart failure, atherosclerosis, and aortic dissection/aneurysm. Furthermore, increasing evidence suggests that inhibiting the cGAS-STING signaling pathway can significantly inhibit myocardial hypertrophy and inflammatory cell infiltration. Therefore, this review is intended to identify risk factors for activating the cGAS-STING pathway to reduce risks and to simultaneously further elucidate the biological function of this pathway in the cardiovascular field, as well as its potential as a therapeutic target.

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Link between sterile inflammation and cardiovascular diseases: Focus on cGAS-STING pathway in the pathogenesis and therapeutic prospect

Cited by 8 publications

References 126 publications

Does cardiac impairment develop in ischemic renal surgery in rats depending on the reperfusion time?

Does cardiac impairment develop in ischemic renal surgery in rats depending on the reperfusion time?

Molecular map of cGAS-STING pathway-related genes in bladder cancer: the perspective toward immune microenvironment and prognosis

The cGAS-STING pathway in cardiovascular diseases: from basic research to clinical perspectives

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