Link between Insulin Resistance and Hypertension: What Have We Learned from Our Ancestors?

Association between hypertension and insulin resistance in non-diabetic adult populations: a community-based study from the Iran

“…The results showed that the mean of TG/HDL as an index of insulin-resistant was significantly different between untreated essential hypertensive and normotensive participants. This finding is consistent with most studies, which referred to the concurrence of hypertension and insulin resistance [9,10]. These two variables are the components of metabolic syndrome and often coexist [30].…”

“…One of the reasons for this finding is that changes take place in the vascular walls associated with higher levels of plasma lipids that can accelerate arteriosclerosis and hypertension [13,34]. So, insulin resistance has been proposed as the main underlying cause of cardiometabolic syndrome [9,10]. Kim and et al showed that four major risk factors for cardiovascular disease in nondiabetic Korean elderly individuals were glucose tolerance impairment, dyslipidemia, hypertension, and obesity [35].…”

“…The ratio of triglyceride (TG) to high-density lipoprotein (HDL-C) (TG/HDL-C) was used as a measure of insulin resistance. According to several studies' definitions, insulin-resistant (IR) was TG/HDL-C ratio greater than 3.0, and insulin-sensitive (IS) was TG/HDL-C ratio less than 2.0 [10,21]. LDL-C was calculated using Friedwald's formula (TG ≤ 400 mg/dL).…”

“…Similar to the prevalence of type 2 diabetes in the Middle East, HTN is rising and it is estimated to be an important public health problem in this region [8]. The common findings in hypertension are hyperinsulinemia and insulin resistance [9,10]. It has been estimated that about half of patients with essential hypertension are insulin-resistant [11].…”