Linguistic Development in a Patient with Landau-Kleffner Syndrome: A Nine-Year Follow-Up

Zardini, G.; Molteni, B.; Nardocci, Nardo; Sarti, Daniela; Avanzini, G.; Granata, Tiziana

doi:10.1055/s-2007-979714

Cited by 16 publications

(6 citation statements)

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“…42,53,71 Analysis of brainstem auditory evoked responses suggested adequate function of subthalamic auditory nuclei, consistent with several previous reports. 18,51,59,[61][62][63][64]67,80 A mild hearing loss (30 dB) was evident with both standard audiometry and on brainstem auditory evoked responses, but this could not account for the severity of her comprehension deficit. By contrast, she demonstrated abnormal steady-state auditory evoked potentials to pulsed FM in sound.…”

Section: Discussionmentioning

confidence: 99%

“…37,57 An alternative view posits that the epileptiform EEG abnormalities are epiphenomena of an as yet ill-defined subacute pathophysiological process. 51,[58][59][60] Recordings of brainstem auditory evoked responses commonly appear normal, 51,59,[61][62][63][64] suggesting that auditory processing deficits in LKS are not, in most cases, the result of significant compromise of the subthalamic auditory pathways. Dysfunction at cortical levels of the auditory system has been suggested based on neuropsychological and EEG features, but supportive evidence from evoked response studies has been inconsistent.…”

Section: Landau-kleffner Syndromementioning

confidence: 99%

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Speech Perceived through a Damaged Temporal Window: Lessons from Word Deafness and Aphasia

Stefanatos

2008

Semin Speech Lang

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Word deafness is an intriguing neurological syndrome characterized by severe difficulties in the ability to understand or reproduce spoken language with otherwise intact speech production and nonauditory language comprehension. The disorder is of significant theoretical importance because it putatively supports the modularity of speech recognition from more central language computational networks. However, the specificity and functional locus of the processing disturbances resulting in word deafness remains unclear. This article discusses the nature and potential treatment of word deafness, with particular reference to a detailed case study (neuropsychological, neuroimaging, and event-related potential) of an adult case of Landau-Kleffner syndrome. The findings in this case suggested temporal lobe pathophysiology involving cortical mechanisms concerned with temporal processing of rapid frequency changes in sound. We propose that these deficits may impede the analysis of linguistically important transitional frequency cues in speech and account for the profound difficulties in understanding and producing speech. The implications of these findings for approaches to the treatment of word deafness are discussed.

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Section: Discussionmentioning

confidence: 99%

Section: Landau-kleffner Syndromementioning

confidence: 99%

Speech Perceived through a Damaged Temporal Window: Lessons from Word Deafness and Aphasia

Stefanatos

2008

Semin Speech Lang

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“…La asociación de trastornos del lenguaje con la epilepsia se da en determinadas patologías, con o sin relación causal. En el síndrome de Landau-Kleffner (SLK) se supone que la afasia es causa directa de la aparición de descargas epilépticas en las áreas del lenguaje [20], de forma que la mejoría en la alteración del lenguaje se ha relacio nado directamente con la desaparición de las crisis y de las anomalías electroencefalográficas durante el sueño [21]. Fisiológicamente, los sistemas del lenguaje se desarrollan tardíamente, y el circuito cere bral subyacente al mismo se establece y se moldea durante los pri meros 8-10 años de vida [22].…”

Section: Discussionunclassified

Alteraciones electroencefalográficas en niños con trastorno por déficit de atención con hiperactividad

Castañeda-Cabrero

Lorenzo-Sanz²,

Caro-Martínez³

et al. 2003

RevNeurol

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Introduction. Attention deficit hyperactivity disorder (ADHD) is a syndrome that affects between 3-5% of the population of school-aged children, and may be accompanied by learning, language, behavioural or motor disorders. Although various electroencephalographic alterations have been described in these patients, their pathological significance has not been determined. There have also been reports of children with neuropsychological and language disorders having epileptiform anomalies in the EEG recording. Patients and methods. We conducted a study of 15 children, with no history of seizures, who had been referred to Child Neurology for treatment and who satisfied the criteria for ADHD according to the DSM-IV and the ADHRS (attention deficit/ hyperactivity rating scale). Results. The EEG recording in the waking state showed significant anomalies in two of our patients (acute spike and wave paroxysmal activity in the left temporoparietal region and spike-wave discharges during hyperventilation). The polysomnographic study revealed specific alterations in four children. There was a continuous spike-wave trace during slow sleep (CSWS) in one case, paroxysmal activity (slow acute waves, spikes) in the temporoparietal region with secondary general ization or transmission (two cases), and frequent generalized paroxysmal discharges of slow acute waves in all phases of sleep (one case). Conclusions. The neurophysiological disorders observed in some of our patients could make it necessary to consider performing a night-time polysomnographic study in certain cases of ADHD.

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“…This is in favour of an auditory processing disorder and not a focal lesion of Wernicke's area. There is a lack of evidence of links between the incidence of overt seizures and the disorder of language function, but not between the latter and the occurrence of spike and wave discharges in the EEG 10,11 .…”

Section: The Landau-kleffner Syndromementioning

confidence: 99%

REVIEW Cognitive functions and epileptic activity

Gordon¹

2000

Seizure

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Epilepsy, and its treatment, can affect the development and use of language in a number of different ways. The seizures may be a symptom of a lesion in areas of the brain essential for language function, and the complications of both the seizures and of the drugs can interfere with learning. However, the purpose of this review is to consider the role of epileptic activity as demonstrated by electrical discharges in the electroencephalogram (EEG), whether these are accompanied by overt seizures or not, on cerebral function especially that of language. The Landau-Kleffner, the continuous spike-waves during sleep, and the benign epilepsy of childhood with Rolandic spikes syndromes are considered; as well as the evidence of epileptic discharges affecting language development. If there are doubts that a patient is suffering from epilepsy the diagnosis may be difficult; and anyone involved in the treatment of language disorders should keep this possibility in mind. Particularly during childhood an EEG, awake and asleep, should be an important part of the assessment of both developmental and acquired dysphasia. The control of overt fits may be relatively easy, but drugs are not so effective in controlling the epileptic activity in the EEG. The treatment of such discharges used to be discouraged, but the evidence is now strongly in favour of employing both medical and surgical treatment. The results in restoring language function are sometimes dramatic.

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Linguistic Development in a Patient with Landau-Kleffner Syndrome: A Nine-Year Follow-Up

Cited by 16 publications

References 0 publications

Speech Perceived through a Damaged Temporal Window: Lessons from Word Deafness and Aphasia

Speech Perceived through a Damaged Temporal Window: Lessons from Word Deafness and Aphasia

Alteraciones electroencefalográficas en niños con trastorno por déficit de atención con hiperactividad

REVIEW Cognitive functions and epileptic activity

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