Lingual salivary gland hypertrophy and decreased acinar density in chagasic patients without megaesophagus

Bertoldo, Bárbara Bellocchio; Etchebehere, Renata Margarida; Furtado, Taíssa Cássia de Souza; Faria, Juliana Barbosa de; Silva, Camilla Beatriz; Araújo, Márcia Fernandes de; Rodrigues, Denise Bertulucci Rocha; Pereira, Sanívia Aparecida de Lima

doi:10.1590/s1678-9946201961067

Cited by 7 publications

(4 citation statements)

References 18 publications

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“…The relation between the tongue and the glandular area were different between groups, the Control group had a higher area of serous glands, while the mdx group had a larger area of mucous glands. Unlike the Control group, the mdx had a massive commitment of greenish collagen in the muscular tissue near the glands; this feature was also seen in the tongue of other pathologies that promote chronic inflammation such as Chagas disease (Bertoldo et al, 2019).…”

Section: Discussionmentioning

confidence: 95%

Structural and Ultrastructural Changes in the Tongue of mdx Mice

et al. 2022

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The mdx mouse is an experimental model of Duchenne muscular dystrophy, a genetic disorder characterized by progressive muscular degeneration which affects the oral cavity musculature, and promotes difficulty in swallowing. This study aimed to describe morphological, structural, and ultrastructural changes in the tongue mucosa and musculature of mdx mice. Forty six-month-old mice were divided into two groups: Control C57bl/10 (n = 20) and mdx C57bl/10 mdx (n = 20). The tongue was dissected and analyzed with light microscopy, scanning electron microscopy, and transmission electron microscopy techniques. Our results showed conical and triangular filiform, fungiform, foliate, and vallate papillae, and their connective tissue cores. The epithelium layers identified were corneum, granulosum, spinosum, and basale. The mdx group had a thicker epithelium. Lamina propria was composed of reddish and greenish collagen. In mdx, collagen was present in the musculature of the tongue's body and in the muscular tissue between mucous and serous glands of the caudal region. Musculature was also characterized by a shorter length of sarcoplasmic invaginations, myocytolysis in mitochondrial groupings, and inflammatory focus. In conclusion, the tongue of 6-month-old mdx mice had morphology, structure, and ultrastructure revealed, showing higher wear of filiform papillae indirect reflex from the muscular degeneration process.

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Section: Discussionmentioning

confidence: 95%

Structural and Ultrastructural Changes in the Tongue of mdx Mice

et al. 2022

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“…When tissue damage occurs, chymase levels increase, attracting neutrophils to the wound site (Wulff and Wilgus, 2013). In a study of the lingual salivary gland, MCTCs were seen around the salivary gland ducts (Bertoldo et al 2019). Furthermore, previous research has shown that MCTC is the most common mast cell population in the oral mucosa and dental pulp (Walsh et al 1995).…”

Section: Discussionmentioning

confidence: 99%

A Histochemical and Immunohistochemical Study on Glandula Mandibularis Mast Cells in Angora Goat

Ertuğrul¹

2021

Kocatepe Veterinary Journal

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Mast cells are particularly in association with structures, especially the skin, respiratory, and digestive systems in proximity to surfaces that interface with the external environment. This study was carry out to demonstrate the distribution and heterogeneity of mast cells in the Angora goat glandula mandibularis by using morphological, histochemical, and immunohistochemical methods. A total of seven healthy male adult Angora goats' mandibular glands were studied. Mast cells were distinctly distinguished by their metachromatic staining in preparates stained with toluidine blue. The cells were observed in various sizes and shapes, especially round, oval, and elongateshaped. Mast cells were seen in both intralobular and interlobular interstitium in glandula mandibularis. Many mast cells were observed in the interlobular interstitium, especially around the blood vessels. The Alcianblue/Safranin O combined staining method was used to determine mast cell heterogeneity. In glandula mandibularis, blue-colored alcian-blue (AB) (+) and pink-red colored safranin O (SO) (+) mast cell subtypes were observed. Chymase positive mast cells were usually observed one by one in both intralobular and interlobular interstitium. As a result, the mandibular gland of Angora goat which is local species was examined; the morphology, locations, heterogeneity of mast cells, and chymase expression were specified.

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“…Therefore, concerns are raised that more extended periods of continuous exposure to high doses of ubiquinone may result in an adaptive malfunction of the salivary glands that warrants precautions. For this reason, the changes in the diameters of salivary glandular serous acini can be considered a sensitive early indicator of salivary gland functional adaptation to an external effector element, including malnutrition or specific disease conditions such as Chagas disease [16,17].…”

Section: Discussionmentioning

confidence: 99%

Histopathological comparison of the salivary glands’ acini and striated ducts after experimental prolonged daily administration of oral ubiquinone doses in rats

Abdullah

Sedeeq

Azzubaidi

2021

Current Issues in Pharmacy and Medical Sciences

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Also called coenzyme Q10 (CoQ10), Ubiquinone is a vitamin-like endogenously produced factor essential for Adenosine triphosphate (ATP) mitochondrial production. Several research studies have reported that the exogenous supplementation of CoQ10 can lead to excessive salivation, especially in patients complaining of dry mouth. The objective of this study was to investigate the effect of long-term daily use of CoQ10 on the salivary glands in experimental animals by comparing the diameters of the glandular acini and striated ducts of a CoQ10-treated group and a control group. Twenty-five white albino rats were randomly divided into two groups; the control group consisted of 10 rats, while the CoQ10-treated group comprised 15 rats. The latter received daily oral treatment of 300 mg/kg CoQ10 for six weeks. Samples of the parotid, submandibular and sublingual glands were then dissected and examined histologically for comparative measurement of the diameters of the glands’ acini and striated ducts. The CoQ10 treated group had mean diameters of the serous acini for the parotid (79.8±11.2 μm) and submandibular (81.07±13.5 μm) glands that were significantly higher (P<0.05) than their diameters in the control group (67.5±8.4 μm and 73.3±13.8 μm), respectively. However, the difference was not statistically significant when comparing the diameters of striated ducts of the CoQ10-treated group and the control group. Continuous and prolonged exposure to exogenous ubiquinone may cause hypertrophic dilation of the acini within the salivary glands, namely the parotid and submandibular glands, which might be the underlying mechanism for excessive salivation. This can be considered a reversible adaptive response.

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Lingual salivary gland hypertrophy and decreased acinar density in chagasic patients without megaesophagus

Abstract: This is an open-access article distributed under the terms of the Creative Commons Attribution License.

Cited by 7 publications

References 18 publications

Structural and Ultrastructural Changes in the Tongue of mdx Mice

Structural and Ultrastructural Changes in the Tongue of mdx Mice

A Histochemical and Immunohistochemical Study on Glandula Mandibularis Mast Cells in Angora Goat

Histopathological comparison of the salivary glands’ acini and striated ducts after experimental prolonged daily administration of oral ubiquinone doses in rats

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