Abstract:Experimental hypertension Vasodilatation Polyphenols Nitric oxide EDHF A B S T R A C T Phenolic compounds of berries, fruits and vegetables affect vascular health. Endotheliumdependent vasodilatation has an important role in blood pressure development by controlling the vascular tone. Endothelial cells produce and release various relaxing and contracting factors, like nitric oxide (NO), cyclo-oxygenase (COX)-derived prostanoids and endothelium-derived hyperpolarizing factor (EDHF). The purpose of this study wa… Show more
“…The data indicate that the leaf extract induced a pronounced endothelium-dependent relaxation involving NO and also to some extent vasorelaxant prostanoids. These observations are in agreement with previous ones showing that several polyphenol-rich sources (i.e; lingonberries [27] and red wine [26]) induced redox-sensitive endothelium-dependent relaxations mostly involving the formation of NO-and, often also, to some extent, EDH.…”
Section: Discussionsupporting
confidence: 93%
“…Several sources of polyphenols including red wines [26], grape juices, berry juices [27] and fruits such as acaí [28] have a potential to improve vascular health by various mechanisms including the induction of vasodi- reporting the content of various phenolic compounds [22] and the antioxidant capacity of extracts using three methods (TEAC, DPPH and ORAC assays, [14]). A correlation has been made between these results and the endothelium-dependent vasorelaxation results at 0.1 mg/mL of extract.…”
BACKGROUND: Endothelial dysfunction is a major hallmark of most types of cardiovascular diseases. Numerous plant extracts have been shown to cause endothelium-dependent relaxations by increasing the endothelial formation of the potent vasoprotective factor, nitric oxide (NO). OBJECTIVE: The ability of different Ribes nigrum L. extracts (Grossulariaceae) to induce endothelium-dependent relaxation by stimulating the endothelial formation of NO was assesssed. METHODS: Ribes nigrum extracts were prepared from buds, berries and leaves by extraction (Acetone:H 2 O:Acetic Acid; 70/28/2 (v/v/v)) and lyophilized after acetone evaporation. The ability of the extracts to stimulate the endothelial formation of NO was assessed using cultured endothelial cells and isolated porcine coronary artery rings. RESULTS: The Ribes nigrum leaf extract increased to a greater extent than the bud and the berry extracts the formation of NO, and up-regulated eNOS mRNA expression in cultured endothelial cells (the stimulatory effects amounted to 197 ± 9%, 134 ± 6% and 118 ± 5%, respectively). The leaf extract induced greater relaxations of isolated coronary arteries with endothelium than the bud and the berry extracts whereas no such effects were observed in rings without endothelium. Relaxations to the leaf extract were minimally affected by indomethacin and by inhibitors of endothelium-dependent hyperpolarization response, and markedly reduced by N G -nitro-L-arginine. CONCLUSIONS: The present findings indicate that the Ribes nigrum leaf extract is a more potent inducer of the endothelial formation of NO than the bud and the berry extracts.
“…The data indicate that the leaf extract induced a pronounced endothelium-dependent relaxation involving NO and also to some extent vasorelaxant prostanoids. These observations are in agreement with previous ones showing that several polyphenol-rich sources (i.e; lingonberries [27] and red wine [26]) induced redox-sensitive endothelium-dependent relaxations mostly involving the formation of NO-and, often also, to some extent, EDH.…”
Section: Discussionsupporting
confidence: 93%
“…Several sources of polyphenols including red wines [26], grape juices, berry juices [27] and fruits such as acaí [28] have a potential to improve vascular health by various mechanisms including the induction of vasodi- reporting the content of various phenolic compounds [22] and the antioxidant capacity of extracts using three methods (TEAC, DPPH and ORAC assays, [14]). A correlation has been made between these results and the endothelium-dependent vasorelaxation results at 0.1 mg/mL of extract.…”
BACKGROUND: Endothelial dysfunction is a major hallmark of most types of cardiovascular diseases. Numerous plant extracts have been shown to cause endothelium-dependent relaxations by increasing the endothelial formation of the potent vasoprotective factor, nitric oxide (NO). OBJECTIVE: The ability of different Ribes nigrum L. extracts (Grossulariaceae) to induce endothelium-dependent relaxation by stimulating the endothelial formation of NO was assesssed. METHODS: Ribes nigrum extracts were prepared from buds, berries and leaves by extraction (Acetone:H 2 O:Acetic Acid; 70/28/2 (v/v/v)) and lyophilized after acetone evaporation. The ability of the extracts to stimulate the endothelial formation of NO was assessed using cultured endothelial cells and isolated porcine coronary artery rings. RESULTS: The Ribes nigrum leaf extract increased to a greater extent than the bud and the berry extracts the formation of NO, and up-regulated eNOS mRNA expression in cultured endothelial cells (the stimulatory effects amounted to 197 ± 9%, 134 ± 6% and 118 ± 5%, respectively). The leaf extract induced greater relaxations of isolated coronary arteries with endothelium than the bud and the berry extracts whereas no such effects were observed in rings without endothelium. Relaxations to the leaf extract were minimally affected by indomethacin and by inhibitors of endothelium-dependent hyperpolarization response, and markedly reduced by N G -nitro-L-arginine. CONCLUSIONS: The present findings indicate that the Ribes nigrum leaf extract is a more potent inducer of the endothelial formation of NO than the bud and the berry extracts.
“…All three kinds of fruit were rich in polyphenols. It could be concluded that endothelium-dependent vasodilatation of spontaneously hypertensive rats could be improved by long-term lingonberry juice treatment [85]. In another study, cranberry juice, which was rich in polyphenols, was investigated and no significant change caused by cranberry juice on peripheral endothelial function was found during the study [86].…”
Section: Mechanisms Of Action Of Juice On Cardiovascular Diseasesmentioning
Many studies have indicated that consumption of vegetables and fruits are positively related to lower incidence of several chronic noncommunicable diseases. Although composition of fruit and vegetable juices is different from that of the edible portion of fruits and vegetables, they contain polyphenols and vitamins from fruits and vegetables. Drinking vegetable and fruit juices is very popular in many countries, and also an efficient way to improve consumption of fruits and vegetables. The studies showed that fruit and vegetable juices affect cardiovascular risk factors, such as lowering blood pressure and improving blood lipid profiles. The main mechanisms of action included antioxidant effects, improvement of the aspects of the cardiovascular system, inhibition of platelet aggregation, anti-inflammatory effects, and prevention of hyperhomocysteinemia. Drinking juices might be a potential way to improve cardiovascular health, especially mixtures of juices because they contain a variety of polyphenols, vitamins, and minerals from different fruits and vegetables. This review summarizes recent studies on the effects of fruit and vegetable juices on indicators of cardiovascular disease, and special attention is paid to the mechanisms of action.
“…In Kivimäki and coauthors` previous study it is shown that lingonberry juice enhanced endothelium-dependent vascular relaxation in spontaneously hypertensive rats (SHR) (Kivimäki et al, 2011). It is suggested that blood pressure -lowering effect of polyphenol-rich foods is partly due to inhibition of angiotensin-converting enzyme (ACE), which is a key regulator of blood pressure (Actis-Goretta et al, 2006; Persson et al, 2011).…”
In this study we tried to see how (1:1 and 3:1) lingonberry extract act as protective agents of the myocardium and blood pressure in toxicosis induced by paracetamol in rats. Experiments were made on white female Wistar rats, weighing 135 ± 20 g which were divided into 6 groups of 7 animals each: control group (C); Paracetamol treated group (P) -75 mg acetaminophen/100 g bw for 10 days. 1:1 lingonberry hidroalcoholic treated group (Lha), (200 mg/100 g bw (80 µg benzoic acid/100 g bw) for 15 days. 3:1 lingonberry dried extract group (Ld), 100 mg/100 g bw (112 µg benzoic acid/100 g bw), for 15 days. P+Lha (PLha) and P + Ld (PLd) treated group. Blood pressure increases following administration of paracetamol and decreases under treatment with lingonberry extract, more obvious to 3: 1 lingonberry dried extract. Administration of Paracetamol, lingonberry extracts used simple or in combination with Paracetamol does not affect the myocardium histological structure. Histoenzimological there is a slight decrease of SDH activity in the groups P and PLd and an increase in Lha group. CyOx activity is increased in Lha and Ld group. The dried lingonberry extract has no apparent action on the myocardium instead has antihypertensive properties more obvious than the lingonberry alcoholic extract.
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