Lingonberry, cranberry and blackcurrant juices affect mRNA expressions of inflammatory and atherothrombotic markers of SHR in a long-term treatment

Kivimäki, Anne; Ehlers, Pauliina I.; Siltari, Aino; Turpeinen, Anu M.; Vapaatalo, Heikki; Korpela, Riitta

doi:10.1016/j.jff.2012.02.010

Cited by 38 publications

(24 citation statements)

References 41 publications

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“…Several in vitro and in vivo studies indicate that anthocyanins and other polyphenols in berries have a range of potential health benefits including anti-oxidant, anti-inflammatory, cytoprotective and neurological effects (Beattie et al, 2005; Karjalainen et al, 2009). Kivimaeki et al (2012) studied vascular anti-inflammatory effects of cranberry ( Vaccinium oxycoccos ), lingonberry ( Vaccinium vitis-idaea ) and black currant ( Ribes nigrum ) juices given as drinking fluid ad libitum to spontaneously hypertensive rats. The mRNA expression of angiotensin-converting enzyme 1 (ACE1), COX-2, MCP-1 and P-selectin was significantly reduced in the cranberry and lingonberry groups (Kivimaeki et al, 2012).…”

Section: Resultsmentioning

confidence: 99%

“…Kivimaeki et al (2012) studied vascular anti-inflammatory effects of cranberry ( Vaccinium oxycoccos ), lingonberry ( Vaccinium vitis-idaea ) and black currant ( Ribes nigrum ) juices given as drinking fluid ad libitum to spontaneously hypertensive rats. The mRNA expression of angiotensin-converting enzyme 1 (ACE1), COX-2, MCP-1 and P-selectin was significantly reduced in the cranberry and lingonberry groups (Kivimaeki et al, 2012). In a study conducted by Hurst et al (2010), a proanthocyanin-enriched black currant fruit extract in contrast to an anthocyanin-enriched extract suppressed both IL-4- and IL-13-stimulated eotaxin-3 (CCL26) secretion in a dose-dependent manner.…”

Section: Resultsmentioning

confidence: 99%

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Ethnopharmacological in vitro studies on Austria's folk medicine—An unexplored lore in vitro anti-inflammatory activities of 71 Austrian traditional herbal drugs

Vogl

Picker

Mihály-Bison

et al. 2013

Journal of Ethnopharmacology

219

130

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Ethnopharmacological relevanceIn Austria, like in most Western countries, knowledge about traditional medicinal plants is becoming scarce. Searching the literature concerning Austria's ethnomedicine reveals its scant scientific exploration.Aiming to substantiate the potential of medicinal plants traditionally used in Austria, 63 plant species or genera with claimed anti-inflammatory properties listed in the VOLKSMED database were assessed for their in vitro anti-inflammatory activity.Material and methods71 herbal drugs from 63 plant species or genera were extracted using solvents of varying polarities and subsequently depleted from the bulk constituents, chlorophylls and tannins to avoid possible interferences with the assays. The obtained 257 extracts were assessed for their in vitro anti-inflammatory activity. The expression of the inflammatory mediators E-selectin and interleukin-8 (IL-8), induced by the inflammatory stimuli tumor necrosis factor alpha (TNF-α) and the bacterial product lipopolysaccharide (LPS) was measured in endothelial cells. The potential of the extracts to activate the nuclear factors PPARα and PPARγ and to inhibit TNF-α-induced activation of the nuclear factor-kappa B (NF-κB) in HEK293 cells was determined by luciferase reporter gene assays.ResultsIn total, extracts from 67 of the 71 assessed herbal drugs revealed anti-inflammatory activity in the applied in vitro test systems. Thereby, 30 could downregulate E-selectin or IL-8 gene expression, 28 were strong activators of PPARα or PPARγ (inducing activation of more than 2-fold at a concentration of 10 µg/mL) and 21 evoked a strong inhibition of NF-κB (inhibition of more than 80% at 10 µg/mL).ConclusionOur research supports the efficacy of herbal drugs reported in Austrian folk medicine used for ailments associated with inflammatory processes. Hence, an ethnopharmacological screening approach is a useful tool for the discovery of new drug leads.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Ethnopharmacological in vitro studies on Austria's folk medicine—An unexplored lore in vitro anti-inflammatory activities of 71 Austrian traditional herbal drugs

Vogl

Picker

Mihály-Bison

et al. 2013

Journal of Ethnopharmacology

219

130

View full text Add to dashboard Cite

show abstract

“…DNA microarray analysis have suggested that IPP and VPP could significantly increase the expression of eNOS, connexin 40, and cyclooxygenase‐1 (COX‐1) genes, whereas decreased the expression of nuclear factor kappa B subunit (NF‐κB) and peroxisome proliferator activator receptor gamma (PPARγ) genes in SHRs . Using RT‐PCR analysis, flavonoids, and phenolic compounds from lingonberry and cranberry have been shown to reduce the expressions of ACE, cyclooxygenase‐2 (COX‐2), monocyte chemoattractant protein‐1 (MCP‐1), and P‐selectin genes and exhibit anti‐inflammatory and anti‐thrombotic effect in SHRs . Another study showed that peanut polyphenols could exert hypolipidemic effects by increasing the expression of fatty acid synthase, sterol receptor element‐binding protein‐1c, acetyl‐CoA carboxylase (ACC1), and PPARγ genes in Wistar rats .…”

Section: Discussionmentioning

confidence: 99%

Egg ovotransferrin‐derived ACE inhibitory peptide IRW increases ACE2 but decreases proinflammatory genes expression in mesenteric artery of spontaneously hypertensive rats

Majumder

Liang

Chen

et al. 2015

Molecular Nutrition Food Res

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ScopeEgg ovotransferrin‐derived angiotensin converting enzyme (ACE) inhibitory peptide IRW was previously shown to reduce blood pressure in spontaneously hypertensive rats through reduced vascular inflammation and increased nitric oxide‐mediated vasorelaxation. The main objective of the present study was to investigate the molecular mechanism of this peptide through transcriptome analysis by RNAseq technique.Methods and resultsTotal RNA was extracted from kidney and mesenteric arteries; the RNAseq libraries (from untreated and IRW‐treated groups) were constructed and subjected to sequence using HiSeq 2000 system (Illumina) system. A total of 12 764 and 13 352 genes were detected in kidney and mesenteric arteries, respectively. The differentially expressed (DE) genes between untreated and IRW‐treated groups were identified and the functional analysis through ingenuity pathway analysis revealed a greater role of DE genes identified from mesenteric arteries than that of kidney in modulating various cardiovascular functions. Subsequent qPCR analysis further confirmed that IRW significantly increased the expression of ACE‐2, ABCB‐1, IRF‐8, and CDH‐1 while significantly decreased the expression ICAM‐1 and VCAM‐1 in mesenteric arteries.ConclusionOur research showed for the first time that ACE inhibitory peptide IRW could contribute to its antihypertensive activity through increased ACE2 and decreased proinflammatory genes expression.

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“…The mRNA expression of COX2, MCP-1, P-selectin, VCAM-1, and ACE were notably reduced in the cranberry and ligonberry extract fed animals [214]. The levels of circulating Ang II were significantly reduced, which otherwise leads to vasoconstriction.…”

Section: Functional Foods Rich In Polyphenolsmentioning

confidence: 99%

Polyphenols: Benefits to the Cardiovascular System in Health and in Aging

et al. 2013

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Numerous studies have demonstrated the importance of naturally occurring dietary polyphenols in promoting cardiovascular health and emphasized the significant role these compounds play in limiting the effects of cellular aging. Polyphenols such as resveratrol, epigallocatechin gallate (EGCG), and curcumin have been acknowledged for having beneficial effects on cardiovascular health, while some have also been shown to be protective in aging. This review highlights the literature surrounding this topic on the prominently studied and documented polyphenols as pertaining to cardiovascular health and aging.

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Lingonberry, cranberry and blackcurrant juices affect mRNA expressions of inflammatory and atherothrombotic markers of SHR in a long-term treatment

Cited by 38 publications

References 41 publications

Ethnopharmacological in vitro studies on Austria's folk medicine—An unexplored lore in vitro anti-inflammatory activities of 71 Austrian traditional herbal drugs

Ethnopharmacological in vitro studies on Austria's folk medicine—An unexplored lore in vitro anti-inflammatory activities of 71 Austrian traditional herbal drugs

Egg ovotransferrin‐derived ACE inhibitory peptide IRW increases ACE2 but decreases proinflammatory genes expression in mesenteric artery of spontaneously hypertensive rats

Polyphenols: Benefits to the Cardiovascular System in Health and in Aging

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