Lingonberry Anthocyanins Inhibit Hepatic Stellate Cell Activation and Liver Fibrosis via TGFβ/Smad/ERK Signaling Pathway

Zhang, Guokun; Jiang, Yunyao; Liu, Xin; Deng, Yongyan; Wei, Bin; Shi, Liyan

doi:10.1021/acs.jafc.1c05384

Cited by 9 publications

(2 citation statements)

References 42 publications

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“…Hyp is one of the main characteristic collagen components, and its content in liver tissues can indirectly refect collagen accumulation. Reducing collagen deposition in the liver tissue can efectively improve liver fbrosis [28][29][30]. Terefore, we evaluated the efects of PA on collagen fbers in the mice's liver using Hyp as the marker.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Phytic Acid on CCl4-Induced Liver Fibrosis in Mice

Zhao

Lan

Han

et al. 2023

Journal of Food Biochemistry

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Liver fibrosis is the main pathological feature of various chronic liver diseases that can progress to cirrhosis. However, no effective treatment strategy for liver fibrosis is available. Phytic acid (PA) is a natural plant compound found in cereals, legumes, and rapeseed. Currently, there are few reports on its relationship with liver fibrosis. Herein, we explored the effects of PA on liver fibrosis. In this study, the liver fibrosis model was constructed by intraperitoneal injection of CCl4 and intragastric administration of sodium phytate (100 mg/kg) or silymarin (100 mg/kg) five times a week. The CCl4 injection could significantly increase the content of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum and induce the damage of liver cells, infiltration of inflammatory factors, and deposition of collagen fibers in the liver tissue. Compared to the CCl4 group, PA significantly reduced AST and ALT. Also, PA alleviated liver damage and reduced inflammatory cell infiltration, collagen deposition area, and hydroxyproline (Hyp) content in the liver tissue, as well as downregulated α-smooth muscle actin (α-SMA) and collagen I (Col-1). Mechanistically, PA downregulated PI3K, p-AKT, p-p65, and p-IκBα in the liver tissue and reduced the release of inflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6). In conclusion, PA might ameliorate liver fibrosis by inhibiting the NF-κB and PI3K/AKT signaling pathways.

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Section: Discussionmentioning

confidence: 99%

Protective Effects of Phytic Acid on CCl4-Induced Liver Fibrosis in Mice

Zhao

Lan

Han

et al. 2023

Journal of Food Biochemistry

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“…Lyian Shi [21] studied rats that were injected intraperitoneally with CCl4 to induce liver fibrosis.…”

Section: Hebatic Stellate Cell Activation and Liver Fibrosismentioning

confidence: 99%

A review on bioactive metabolites and great biological effects of Cranberry

Mahmoud

Ahmed

et al. 2023

ERU Research Journal

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The Cranberry (Genus Vaccinium) is characterized by its high content of acids, sugars, and antioxidants. Some of the latter have been studied for their potential action against the adhesion of bacteria and many microorganisms to the mucous membranes of the body. The effect observed is "mechanical" and not "bactericidal", so there is no risk of developing resistance phenomena. Cranberry and its juice were thus the first plant extracts in the world used to prevent the adhesion of Escherichia coli bacteria on the uro-epithelial cells lining the genitourinary tract and treat recurrent cystitis. It prevents stomach ulcers through prevention the attachment of Helicobacter Pylori bacteria to the stomach wall. Cranberry is used against dental plaque due to its anti-adhesion effect and has positive repercussions on the formation of dental plaque and gum inflammation. Cranberry products, made from the North American cranberry, have long been thought to be effective in helping prevent urinary tract infections (is one of the most common infections in women, requiring antibiotic treatment.). The American cranberry, which is mainly consumed in the form of cranberry juice (CJ), is regarded as a promising functional food for the prevention of chronic diseases such as cancer, heart diseases, type 2

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