Ling-Yang-Gou-Teng-decoction prevents vascular dementia through inhibiting oxidative stress induced neurovascular coupling dysfunction

Zhao, Xiulan; Liu, Jinyu; Yang, Shi Yu; Song, Dandan; Wang, Chen; Chen, Chen; Li, Xiaoya; Ge, Shasha; Yang, Ruijie; Li, Xiuhua; Lin, Yulin; Cai, Duan

doi:10.1016/j.jep.2018.03.015

Cited by 15 publications

(11 citation statements)

References 35 publications

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“…and molecular biological reactions [7][8][9][10][11] . In view of their close relationship, more and more scholars pay heed to the potential mechanism of CCH induced VD in order to provide promising therapeutic methods.…”

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confidence: 99%

Effects of imperatorin on apoptosis and synaptic plasticity in vascular dementia rats

Huang

Liao

Wang

et al. 2021

Sci Rep

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In view of the complicated pathophysiological process of vascular dementia (VD), drugs for the clinical treatment of VD mainly target related risk factors, while drugs with excellent efficacy in cognitive function are still relatively lacking. Imperatorin (IMP), an active constituent extracted from angelica dahuricae and notopterygium Notopterygii, which has anti-inflammatory, vasodilator, anticoagulant, block calcium channel, anticonvulsant, and anti oxygen free radical injury properties. Therefore,the present study examined its effects on VD rats and the underlying molecular mechanisms, in order to provide promising therapeutic methods. VD was established by modified ligation of perpetual two-vessel occlusion (2VO). After 2VO surgery, IMP (2.5, 5, and 10 mg/kg) was administered by intraperitoneal injection for 12 consecutive weeks to evaluate therapeutic effects. Cognitive function was verified by the Morris water maze. The neuronal morphological changes were examined via Hematoxylin–Eosin staining. Real-Time PCR and Western blot were used for detecting pro- and antiapoptotic biomarkers, and the hippocampus synaptic damage was examined by Transmission electron microscope. We revealed that 2VO-induced cognitive impairment, hippocampus CA1 neuron damage, apoptosis and synaptic damage. IMP-treatment significantly improved 2VO-induced cognitive deficits and hippocampus neuron damage. Molecular analysis revealed that IMP inhibited apoptosis through the down regulation of Bax, Caspase-3 and upregulation of Bcl-2. Meanwhile, IMP-treatment markedly improved synaptic ultrastructure morphology, increased the SAZ length, PSD thickness and up-regulated PSD-95 expression. Collectively, our findings demonstrated that IMP was effective in the treatment of 2VO-induced VD via inhibiting apoptosis of hippocampus neurons and reducing the synaptic plasticity destroy.

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confidence: 99%

Effects of imperatorin on apoptosis and synaptic plasticity in vascular dementia rats

Huang

Liao

Wang

et al. 2021

Sci Rep

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“…Thus, for the first time, we demonstrated that HGWWD prevented STZ-induced vascular dysfunction through arginase 1-NO signaling in vascular endothelial cells. Similarly, some other traditional medicines treated the vascular pathology involved in mechanisms with regulating vascular endothelium dysfunction and NO production, including Yangxin Decoction (Li et al, 2011), Taohong Siwu Decoction (Zhang, 2014), Shixiao San (Wang X. et al, 2015), Ling-Yang-Gou-Teng-decoction (Zhao et al, 2018). Moreover, our previous study also found that Xiao-Shen-Formula prevented the impairment of renal microvascular remodeling via inhibiting arginase activation (An et al, 2018).…”

Section: Discussionmentioning

confidence: 83%

HuangqiGuizhiWuwu Decoction Prevents Vascular Dysfunction in Diabetes via Inhibition of Endothelial Arginase 1

et al. 2020

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Hyperglycemia induces vascular endothelial dysfunction, which contributes to the development of vascular complication of diabetes. A classic prescription of traditional medicine, HuangqiGuizhiWuwu Decoction (HGWWD) has been used for the treatment of various cardiovascular and cerebrovascular diseases, which all are related with vascular pathology. The present study investigated the effect of HGWWD treatment in streptozocin (STZ)-induced vascular dysfunction in mouse models. In vivo studies were performed using wild type mice as well as arginase 1 knockout specific in endothelial cells (EC-A1 −/−) of control mice, diabetes mice and diabetes mice treated with HGWWD (60 g crude drugs/kg/d) for 2 weeks. For in vitro studies, aortic tissues were treated with mice serum containing HGWWD with or without adenoviral arginase 1 (Ad-A1) transduction in high glucose (HG) medium. We found that HGWWD treatment restored STZ-induced impaired mean velocity and pulsatility index of mouse left femoral arteries, aortic pulse wave velocity and vascular endothelial relaxation accompanied by elevated NO production in the aorta and plasma, as well as reduced endothelial arginase activity and aortic arginase 1 expression. The protective effect of HGWWD is reversed by an inhibitor of nitric oxide synthesis. Meanwhile, the preventive effect of serum containing HGWWD in endothelial vascular dysfunction is completely blocked by Ad-A1 transduction in HG incubated aortas. HGWWD treatment further improved endothelial vascular dysfunction in STZ induced EC-A1 −/− mice. This study demonstrates that HGWWD improved STZ-induced vascular dysfunction through arginase 1-NO signaling, specifically targeting endothelial arginase 1.

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“…Chronic cerebral hypoperfusion due to various reasons results in glucose and oxygen depletion in the CNS, leading to the pathophysiological process of VD ( Figure 1 ), which includes oxidative stress, inflammatory response, cell apoptosis, autophagy, and synaptic damage [ 236 , 237 , 238 , 239 ]. Although the precise mechanism for hippocampal synaptic dysfunction is unclear, the previously mentioned pathophysiological processes are suggested as the primary causes for the synaptic ultrastructural changes, synaptic loss, and reduction in PSD thickness [ 224 ].…”

Section: Hippocampal Dysfunction In Neurodegenerative Diseasesmentioning

confidence: 99%

Structural Plasticity of the Hippocampus in Neurodegenerative Diseases

Weerasinghe-Mudiyanselage

Ang

Kang

et al. 2022

IJMS

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Neuroplasticity is the capacity of neural networks in the brain to alter through development and rearrangement. It can be classified as structural and functional plasticity. The hippocampus is more susceptible to neuroplasticity as compared to other brain regions. Structural modifications in the hippocampus underpin several neurodegenerative diseases that exhibit cognitive and emotional dysregulation. This article reviews the findings of several preclinical and clinical studies about the role of structural plasticity in the hippocampus in neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and multiple sclerosis. In this study, literature was surveyed using Google Scholar, PubMed, Web of Science, and Scopus, to review the mechanisms that underlie the alterations in the structural plasticity of the hippocampus in neurodegenerative diseases. This review summarizes the role of structural plasticity in the hippocampus for the etiopathogenesis of neurodegenerative diseases and identifies the current focus and gaps in knowledge about hippocampal dysfunctions. Ultimately, this information will be useful to propel future mechanistic and therapeutic research in neurodegenerative diseases.

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Ling-Yang-Gou-Teng-decoction prevents vascular dementia through inhibiting oxidative stress induced neurovascular coupling dysfunction

Cited by 15 publications

References 35 publications

Effects of imperatorin on apoptosis and synaptic plasticity in vascular dementia rats

Effects of imperatorin on apoptosis and synaptic plasticity in vascular dementia rats

HuangqiGuizhiWuwu Decoction Prevents Vascular Dysfunction in Diabetes via Inhibition of Endothelial Arginase 1

Structural Plasticity of the Hippocampus in Neurodegenerative Diseases

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