Linfoma Não-Hodgkin de Alto Grau - Revisão da Literatura

Araujo, Luiz H.; Victorino, Ana Paula; Melo, Andréia Cristina de; Assad, Daniele Xavier; Lima, Danilo Silva; Alencar, Divaldo Rodrigues de; Moreira, Melba Moura Lobo; Filho, Otto Metzger; Coelho, Rafaela de Faria de Souza; Asmar, Selem Brandão; Pereira, Bruno dos Santos Vilhena; Scheliga, Adriana

doi:10.32635/2176-9745.rbc.2008v54n2.1747

Cited by 6 publications

(4 citation statements)

References 42 publications

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“…Most of the studied NHL cases were diagnosed as B-cell lymphoma, with a higher incidence of diffuse large B-cell lymphoma (DLBCL) (82; 38.1%) and follicular lymphoma (40; 18.6%). This corresponds to the incidences found in the literature for the different histological subtypes of NHL, which are the high-grade and aggressive subtypes [1,19].…”

Section: Discussionsupporting

confidence: 85%

Investigation of occupational risk factors for the development of non-Hodgkin’s lymphoma in adults: A hospital-based case-control study

Sarpa,

da Costa,

Ferreira

et al. 2024

PLoS ONE

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Non-Hodgkin’s Lymphoma (NHL) is a malignancy of the lymphoid lineage of the hematopoietic system has worldwide, especially in developed countries. Better diagnostic and recording techniques, longer life expectancy, and greater exposure to risk factors are hypotheses for this growing incidence curve. Occupational exposures to chemical, biological, and physical agents have also been associated with NHL development, but the results are still controversial. We have investigated the occupational and lifestyle case-control study design with 214 adult patients and 452 population controls. Socio-demographic, clinical, and occupational exposure data were obtained through individual interviews with a standardized questionnaire. Clinical, laboratory, and histopathological data were obtained through medical records. Risk of NHL (any subtype), B-cell lymphoma, DLBCL, Follicular lymphoma and T-cell lymphoma was elevated among the those who had ever been exposed to any solvents, hydrocarbon solvents, pesticides, meat and meat products, and sunlight and tended to increase by years of exposure. A significant upward trend with years of exposure was detected for any solvents and hydrocarbon solvents (NHL (any subtype) p-value for trend<0.001), B-cell lymphoma (p-value for trend<0.001), and T-cell lymphoma (p-value for trend<0.023), pesticides (NHL (any subtype), p for trend<0.001) and T-cell lymphoma (p for trend<0.002), meat and meat products (NHL (any subtype) (p for trend<0.001) and DLBCL (p for trend<0.001), and sunlight (B-cell lymphoma (p for trend<0.001). The results of this study agree line with other international studies, can be extrapolated to other countries that have the same socio-demographic and occupational characteristics as Brazil and support strategies for surveillance and control of work-related cancer.

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Section: Discussionsupporting

confidence: 85%

Investigation of occupational risk factors for the development of non-Hodgkin’s lymphoma in adults: A hospital-based case-control study

Sarpa,

da Costa,

Ferreira

et al. 2024

PLoS ONE

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“…Moreover, it is the ninth leading cause of cancer-related death in males and seventh in females, contributing to 5% of cancer-related deaths. High-grade lymphomas account for approximately 50% of all NHL cases, including anaplastic large-cell lymphoma [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

“…Adenopathy predominates in the cervical, supraclavicular, or inguinal chains, but any chain can be affected [ 3 ]. Therefore, biopsy should be recommended whenever a lymph node has the following characteristics: size greater than one centimeter, supraclavicular location, multiple nodal sites, progressive growth, hardened consistency, or adherence to deep planes [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

Non-Hodgkin's Anaplastic Large T-Cell Lymphoma: A Case Report

Halpern,

Miziara Brochi,

Gomes

et al. 2024

Cureus

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Anaplastic large T/null cell lymphoma (ALCL) is an aggressive non-Hodgkin’s lymphoma (NHL) that most commonly affects young men. Herein, we present a case of a 32-year-old male patient in severe condition with ulcerated right axillary adenopathy, diffuse subcutaneous nodules, and sepsis. He was admitted to the ED, where a bone marrow aspirate and biopsy confirmed the diagnosis of ALCL. The immunohistochemical examination demonstrated neoplastic cells with immunopositivity with antibodies CD3 (focal), CD30 (diffuse), protein ALK-1 (diffuse), and epithelial membrane antigen (EMA) (multifocal). Appropriate chemotherapy treatment was done, and the patient showed a complete response. This article aims to report a rare subtype of NHL to increase awareness and bring up a discussion about the clinical presentation and diagnostic features of ALCL. Moreover, we discuss treatment regimens that are currently used and have shown reasonable disease remission rates.

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“…Lymphomas are neoplastic transformations of lymphoid cells 8 , most of them with uncertain etiology, but it has been suggested that its development may be related to heredity, environment, occupation, and diet 9,10 . They are classified as either Hodgkin's (HL) or non-Hodgkin's (NHL).…”

Section: Introductionmentioning

confidence: 99%

Acute Kidney Injury after Bone Marrow Transplantation in Patients with Lymphomas and Leukemias

Mota¹,

Alves

Canicoba

et al. 2023

Rev. Bras. Cancerol.

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Introduction: Hematologic malignancies, including lymphomas and leukemias, may be treated with autologous or allogeneic bone marrow transplantation. However, these approaches can increase the risk of infection, sepsis, graft-versus-host disease, and nephrotoxicity, possibly resulting in acute kidney injury (AKI). Objective: To evaluate AKI in patients with lymphomas or leukemia submitted to bone marrow transplantation (BMT). Method: Retrospective, observational cohort study of cases from a database of 256 patients (53.9% males) hospitalized for BMT between 2012 and 2014 at a cancer hospital in Sao Paulo, Brazil. Of these, 79 were selected randomly for analysis. Demographic data, length of hospitalization, and associated morbidities were recorded. AKI was identified according to Kidney Diseases Improving Global Outcomes (KDIGO) criteria. Results: The most frequent diagnoses for the 79 cases were non-Hodgkin’s lymphoma (30.4%), acute myeloid leukemia (26.6%), and Hodgkin’s lymphoma (24.1%). The probability of 100 days-survival after BMT was 81%, and three years after BMT was 61%. In-hospital mortality was significantly higher among patients who presented AKI during hospitalization (p<0.001). However, there was no difference in overall life expectancy (p=0.770). Conclusion: A significant prevalence of AKI was found in patients with leukemia or lymphoma while they were hospitalized for BMT, resulting in significantly increased rates of in-hospital mortality. The presence of AKI during hospitalization was not associated with a subsequent reduction in life expectancy.

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Linfoma Não-Hodgkin de Alto Grau - Revisão da Literatura

Cited by 6 publications

References 42 publications

Investigation of occupational risk factors for the development of non-Hodgkin’s lymphoma in adults: A hospital-based case-control study

Investigation of occupational risk factors for the development of non-Hodgkin’s lymphoma in adults: A hospital-based case-control study

Non-Hodgkin's Anaplastic Large T-Cell Lymphoma: A Case Report

Acute Kidney Injury after Bone Marrow Transplantation in Patients with Lymphomas and Leukemias

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