Linfoma de células T/NK extranodal tipo nasal

Accurate Diagnose and management of advanced nasal type extranodal NK/T cell lymphoma. A case Report.

“…Despite being a low-prevalence pathology in our continent, the NK-cell lymphoma is being more frequently diagnosed and patient's survival rate has increased. The initial symptoms are non-specific and include nasal obstruction and rhinorrhea with recurrent bacterial sinusitis (5,6). As the disease progresses, a unilateral collapse of the nasal cavity and oronasal fistula may appear due to edema, necrosis and major destruction of the tissue in the facial midline (6).…”

“…The initial symptoms are non-specific and include nasal obstruction and rhinorrhea with recurrent bacterial sinusitis (5,6). As the disease progresses, a unilateral collapse of the nasal cavity and oronasal fistula may appear due to edema, necrosis and major destruction of the tissue in the facial midline (6). Cutaneous manifestations have the highest prevalence among systemic symptoms.…”

“…Bad prognosis markers at the time of diagnosis are extensive local invasion, lymph nodes compromise, metastases, high levels of LDH, history of EVB infection and systemic inflammatory response syndrome (6). Likewise, classifying the disease based on the TNM system is essential to define the treatment and the prognosis (10) ( Table 2).…”

“…The survival rate ranges between 35% and 85% depending on the severity of symptoms and the local extension. Different case series show a high local recurrence rate of 50% (5) and metastasis in only 13% of patients in skin, lungs and gastrointestinal tract, which represents the order of frequency and worst prognosis (6,7). A correct diagnosis is important to define the type of treatment, which may include surgical procedures, chemotherapy or radiotherapy (8).…”