Linfoma cutáneo de células B tipo centro folicular con infiltración a médula ósea reporte de un caso

Abstract

ResumenLos linfomas cutáneos primarios de células B constituyen cerca del 20-25% de todos los linfomas. El linfoma cutáneo primario de células B tipo centro folicular es el subtipo más frecuente y se manifiesta principalmente en pacientes adultos con una edad media de 58 años (1), la diseminación extra-cutánea es muy rara y se presenta con nódulos, tumores o placas solitarios o en grupo usualmente localizados en cabeza o tronco. Presentamos el caso de una paciente con un linfoma primario cutáneo tipo centro folicular con infiltración a médula ósea.Palabras clave: Linfomas cutáneos de células B, linfoma centro folicular. PRIMARY CUTANEOUS FOLLICLE CENTER LYMPHOMA WITH BONE MARROW INFILTRATION AbstractPrimary B cell cutaneous lymphomas represent approximately 20-25% of all lymphomas. Primary cutaneous follicle center lymphoma is the most common subtype occurring in adults with a mean age of 58 years. The disease typically presents with solitary plaques or nodules and is usually located in the head or trunk. Extra cutaneous dissemination is extremely rare. We present a case of a patient with primary cutaneous follicle center lymphoma with bone marrow infiltration.

Primary cutaneous follicle center lymphoma

“…Confirmation, however, is obtained essentially by histological and immunohistochemical examinations. 2 Follicular center cells usually express CD20+, CD79a+, BCL-6+, and BCL-2- (possibly with a weak BCL-2 expression in a minority of B cells), with variable CD43 and CD106 expression. Treatment of choice is based on histology, anatomical location, and number of tumor lesions.…”

“…Treatment of choice is based on histology, anatomical location, and number of tumor lesions. 2 Radiation therapy is one of the preferred options in cases of a few lesions or if they are restricted to a single area. Although it can also be used in cases of late recurrences, the optimal dose and the number of treatment sessions has not yet been well established.…”

“… 1 Primary cutaneous follicle-center B-cell lymphoma is the most common subtype, representing about 55% of cases. 2 …”