Linezolid induced toxic optic neuropathy

Kulkarni, Kirankumar N; Priore, Lucian V. Del

doi:10.1136/bjo.2005.074237

Cited by 34 publications

(26 citation statements)

References 11 publications

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“…In the present case, although slight optic disc hyperemia was seen in both eyes, fl uorescein angiography results were normal. Javaheri et al 10 and Kulkarni and Del Priore 5 also reported normal fl uorescein angiography fi ndings in cases of linezolid-associated optic neuropathy with optic disc hyperemia 10 or pallor, 5 whereas the fi ndings in cases of retrobulbar optic neuritis caused by sarcoidosis showed minimal leakage in the late arteriovenous phase. 20 Thus, fl uorescein angiography is considered helpful in the diagnosis of linezolidassociated optic neuropathy.…”

Section: Discussionmentioning

confidence: 94%

Linezolid-associated optic neuropathy in a patient with ocular sarcoidosis

Kiuchi¹,

Miyashiro²,

Kitagawa³

et al. 2009

Jpn J Ophthalmol

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Section: Discussionmentioning

confidence: 94%

Linezolid-associated optic neuropathy in a patient with ocular sarcoidosis

Kiuchi¹,

Miyashiro²,

Kitagawa³

et al. 2009

Jpn J Ophthalmol

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“…[60][61][62][63] Both peripheral and optic neuropathy have been reported with prolonged use greater than four consecutive weeks. 64,65 Lactic acidosis has also been reported and is not associated with duration of administration. 65,66 Interaction exists between linezolid and serotonin-reuptake inhibitors (antidepressants drugs).…”

Section: Linezolidmentioning

confidence: 90%

Novel pharmaceutical molecules against emerging resistant gram-positive cocci

Manfredi¹,

Sabbatani²

2010

Braz J Infect Dis

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Introduction: methicillin-and also vancomycin (glycopeptide)-resistant Gram-positive organisms have emerged as an increasingly problematic cause of hospital-acquired infections, also spreading into the community. Vancomycin (glycopeptide) resistance has emerged primarily among Enterococci, but the MIC values of vancomycin for the entire Staphylococcus species are also increasing worldwide. Material and Methods: the aim of our review is to evaluate the efficacy and tolerability of newer antibiotics with activity against methicillin-resistant and glycopeptide-resistant Gram-positive cocci, on the ground of our experience at a tertiary care metropolitan Hospital, and the most recent literature evidences in this field. Results: Quinupristin-dalfopristin, linezolid, daptomycin, and tigecycline show an excellent in vitro activity, comparable to the activity of vancomycin and teicoplanin for methicillin-resistant staphylococci, and superior to the one that vancomycin for vancomycin-resistant isolates. Dalbavancin, televancin, and oritavancin are new lipoglycopeptide agents with excellent activity against Gram-positive cocci, and have superior pharmacodynamics properties compared to vancomycin. We review the bacterial spectrum, clinical indications and practical use, pharmacologic properties, and expected adverse events and contraindications associated with each of these novel antimicrobial agents, compared with the present standard of care. Discussion: linezolid activity is substantially comparable to that of vancomycin in patients with methicillin-resistant Staphylococcus aureus (MRSA) pneumonia, although its penetration into the respiratory tract is exceptionally elevated. Tigecycline has activity against both Enterococus species and MRSA; it is also active against a broad spectrum of Enterobacteriaceae and anaerobes, which allows for use intraabdominal, diabetic foot and surgical infections. Daptomycin has a rapid bactericidal activity for Staphylococcus aureus and it is approved in severe complications, such as bacteremia and right-sided endocarditis. It cannot be used to treat pneumonia and respiratory diseases, due to its inactivation in the presence of pulmonary surfactant.

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“…Anecdotal reports suggest that cytopenias may be ameliorated or prevented by coadministration of vitamin B6 [75]. Both peripheral and optic neuropathy have been reported with use for 128 days [76][77][78]. Lactic acidosis has also been reported [78].…”

Section: Bacteremia and Endocarditismentioning

confidence: 95%

Serious Infections Caused by Methicillin‐ResistantStaphylococcus aureus

2010

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Although first identified just >4 decades ago, methicillin-resistant Staphylococcus aureus (MRSA) has undergone rapid evolutionary changes and epidemiologic expansion to become a major cause of nosocomial and community-acquired infections worldwide. Increasing resistance to vancomycin among MRSA strains in conjunction with availability of new antibiotics, including daptomycin and linezolid, have increased treatment choices but made clinical treatment decisions more challenging. This article describes the clinical features and management issues of 2 challenging-to-treat manifestations of MRSA infection, bacteremia and/or endocarditis and osteomyelitis. It also presents a brief review of community-associated MRSA infections and preventive strategies directed against MRSA.

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Linezolid induced toxic optic neuropathy

Cited by 34 publications

References 11 publications

Linezolid-associated optic neuropathy in a patient with ocular sarcoidosis

Linezolid-associated optic neuropathy in a patient with ocular sarcoidosis

Novel pharmaceutical molecules against emerging resistant gram-positive cocci

Serious Infections Caused by Methicillin‐ResistantStaphylococcus aureus

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