Linezolid: a promising option in the treatment of Gram-positives

Abstract

Linezolid, an oxazolidinone antimicrobial agent that acts by inhibiting protein synthesis in a unique fashion, is used in the treatment of community-acquired pneumonia, skin and soft-tissue infections and other infections caused by Gram-positive bacteria including VRE and methicillin-resistant staphylococci. Currently, linezolid resistance among these pathogens remains low, commonly <1.0%, although the prevalence of antibiotic resistance is increasing in many countries. Therefore, the development of resistance by clinical isolates should prompt increased attention of clinical laboratories to routinely perform linezolid susceptibility testing for this important agent and should be taken into account when considering its therapeutic use. Considering the importance of linezolid in the treatment of infections caused by Gram-positive bacteria, this review was undertaken to optimize the clinical use of this antibiotic.

Genetic Basis of Emerging Vancomycin, Linezolid, and Daptomycin Heteroresistance in a Case of Persistent Enterococcus faecium Bacteremia

“…2 ). We did not find other determinants associated with linezolid resistance, such as other mutations in the 23S rRNA gene ( 23 – 25 ) or genes encoding ribosomal proteins L3, L4, and L22 ( 23 , 26 ) or the acquisition of cfr ( 27 , 28 ) or optrA ( 29 ). Consistent with previous observations ( 24 ), strains with higher linezolid MICs had more G2,576U mutant 23S rRNA gene copies, indicating that these mutations were responsible for the observed heteroresistance phenotype.…”

Ruthenium Porphyrin Catalyzed Synthesis of Oxazolidin‐2‐ones by Cycloaddition of CO2 to Aziridines

“…Over the last decades, aziridines have been extensively studied as starting materials due to the high energy of the strained ring which permits the transformation of aziridines into a large variety of fine chemicals by ring‐opening reactions Among all the organic transformations involving aziridines, the insertion of CO 2 into the three‐membered ring is responsible for the synthesis of oxazolidin‐2‐ones, which are the pharmaceutically active moieties of several antibacterial and antimicrobial compounds, such as Linezolid, Tedizolid and Radezolid . In addition, oxazolidin‐2‐ones are widely used as chiral auxiliaries in various asymmetric synthetic reactions…”

Complete Genome Sequence and Characterization of Linezolid-Resistant Enterococcus faecalis Clinical Isolate KUB3006 Carrying a cfr(B)-Transposon on Its Chromosome and optrA-Plasmid

“…Since gaining regulatory approval in 2000 for clinical use, linezolid (LZD) has become one of the most important antimicrobial agents for infections caused by gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin (VCM)-resistant enterococci ( Zahedi Bialvaei et al, 2017 ). Enterococcus faecalis is a lactic acid-producing gram-positive bacterium that is commonly found in the intestinal tracts of humans and animals and is implicated in several fatal clinical infections, such as bacteremia and infective endocarditis ( Dahl and Bruun, 2013 ; Falcone et al, 2015 ; Beganovic et al, 2018 ).…”