Linearization of the Disposition Index equation allows evaluation of secretion-sensitivity coupling slopes

Mather, Kieren J.; Chen, Melinda; Hannon, Tamara S.

doi:10.1016/j.jdiacomp.2020.107589

Cited by 6 publications

(2 citation statements)

References 34 publications

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“…Basal and postprandial insulin clearance were calculated as the ratio of fasting C–peptide to insulin, and the incremental area under the curve (iAUC) of C-peptide to iAUC insulin, calculated using the trapezoidal method, respectively. The oral disposition index (oDI), which reflects insulin secretion adjusted for the level of insulin sensitivity ( 26 , 27 , 28 ), was calculated as the product of the C-peptide index and Matsuda index ( 23 ) which demonstrated a hyperbolic relationship and was used as the measure of beta-cell function. These calculations were only performed in participants without known T2D and/or not taking medications for T2D, and who underwent an OGTT.…”

Section: Methodsmentioning

confidence: 99%

Increased risk for type 2 diabetes in relation to adiposity in middle-aged Black South African men compared to women

Kufe

Micklesfield

Masemola

et al. 2022

European Journal of Endocrinology

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Aims: Despite a higher prevalence of overweight/obesity in black South African women compared to men, the prevalence of type 2 diabetes does not differ. We explored if this could be due to sex differences in insulin sensitivity, clearance and/or beta-cell function, and also sex-specific associations with total and regional adiposity. Methods: This cross-sectional study included 804 black South African men (n=388) and women (n=416). Dual-energy x-ray absorptiometry was used to measure total and regional adiposity. Insulin sensitivity (Matsuda index), secretion (C-peptide index) and clearance (C-peptide/insulin ratio) were estimated from an oral glucose tolerance test. Results: After adjusting for sex differences in fat mass index, men were less insulin sensitive and had lower beta cell function than women (p<0.001), with the strength of the associations with measures of total and central adiposity being greater in men than women (p<0.001 for interactions). Further, the association between total adiposity and type 2 diabetes risk was also greater in men than women (relative risk ratio (95% confidence interval): 2.05 (1.42–2.96), p<0.001 vs. 1.38 (1.03–1.85), p=0.031). Conclusion: With increasing adiposity, particularly increased centralisation of body fat linked to decreased insulin sensitivity and beta cell function, black African men are at greater risk for type 2 diabetes than their female counterparts.

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Section: Methodsmentioning

confidence: 99%

Increased risk for type 2 diabetes in relation to adiposity in middle-aged Black South African men compared to women

Kufe

Micklesfield

Masemola

et al. 2022

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Basal and postprandial insulin clearance were calculated as the ratio of fasting C-peptide to insulin, and the incremental area under the curve (iAUC) of C-peptide to iAUC insulin, calculated using the trapezoidal method, respectively. The oral disposition index (oDI), which reflects insulin secretion adjusted for the level of insulin sensitivity (26)(27)(28), was calculated as the product of the C-peptide index and Matsuda index (23) which demonstrated a hyperbolic relationship and was used as the measure of beta-cell function. These calculations were only performed in participants without known T2D and/or not taking medications for T2D, and who underwent an OGTT.…”

Section: Calculations From the Ogttmentioning

confidence: 99%

Increased Risk for Type 2 Diabetes in Relation to Adiposity in Middle-Aged Black South African Men compared to Women

Kufe

Micklesfield

Masemola

et al. 2021

Preprint

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Aims: Despite a higher prevalence of overweight and obesity in black South African women compared to men, the prevalence of type 2 diabetes does not differ. We explored if this could be due to sex differences in insulin sensitivity, clearance and or beta cell function, and also sex-specific associations with total and regional adiposity. Methods: This cross-sectional study included 804 black South African men (n=388) and women (n=416). Dual-energy x ray absorptiometry was used to measure total and regional adiposity. Insulin sensitivity (Matsuda index), secretion (C peptide index) and clearance (C peptide/insulin ratio) were estimated from an oral glucose tolerance test. Results: After adjusting for sex differences in fat mass index, men were less insulin sensitive and had lower beta cell function than women (p<0.001), with the strength of the associations with measures of total and central adiposity being greater in men than women (p<0.001 for interactions). Further, the association between total adiposity and type 2 diabetes risk was also greater in men than women (relative risk ratio (95% confidence interval): 2.05 (1.42 to 2.96), p<0.001 vs. 1.38 (1.03 to 1.85), p=0.031). Conclusion: With increasing adiposity, particularly increased centralisation of body fat linked to decreased insulin sensitivity and beta cell function, Black African men are at greater risk for type 2 diabetes than their female counterparts.

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MG53 marks poor beta cell performance and predicts onset of type 2 diabetes in subjects with different degrees of glucose tolerance.

Bianchi

Raggi

Rossi

et al. 2022

Diabetes & Metabolism

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Linearization of the Disposition Index equation allows evaluation of secretion-sensitivity coupling slopes

Cited by 6 publications

References 34 publications

Increased risk for type 2 diabetes in relation to adiposity in middle-aged Black South African men compared to women

Increased risk for type 2 diabetes in relation to adiposity in middle-aged Black South African men compared to women

Increased Risk for Type 2 Diabetes in Relation to Adiposity in Middle-Aged Black South African Men compared to Women

MG53 marks poor beta cell performance and predicts onset of type 2 diabetes in subjects with different degrees of glucose tolerance.

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