There is an increase in the utilization of the floating offshore structure (FOS) called Catenary Anchor Leg Mooring (CALM) buoys and the attached marine hoses due to the increasing demand for oil and gas products. These hoses are flexible and easier to use but have a short service life of about 25 years. They are adaptable in ocean locations of shallow, intermediate and deep waters. In this research, a numerical model was developed using a coupling method modeled by utilizing ANSYS AQWA and Orcaflex (Orcina Ltd., Ulverston, UK) dynamic models of the CALM buoy hoses. Two cases were comparatively studied: Lazy-S and Chinese-lantern configurations, under ocean waves and current. Comparisons were also made between coupled and uncoupled models. This research presents the hydrodynamic characteristics with a sensitivity analysis on the influence of waves, current attack angle, soil gradient, soil stiffness and environmental conditions that influence the performance of marine hoses. The study comparatively looked at the configurations from dynamic amplification factors (DAF) on marine hoses. The results show that marine hoses can be easily configured to suit the designer’s need, seabed soil type, seabed topography and the profiles that are useful for manufacturers. The sensitivity analysis also shows the effect of hose parameters on its hydrodynamic behavior from the wave–current interaction (WCI).